Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Jack Spira"'
Autor:
Kenneth C. Anderson, Rolf Lewensohn, Paul Richardson, Nikhil Munshi, Claudia Paba-Prada, Jack Spira, Kristina Viktorsson, Arghya Ray, Dharminder Chauhan
PDF file - 66K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f065fa055a3e236872e0e0fbe91ecc
https://doi.org/10.1158/1078-0432.22450782.v1
https://doi.org/10.1158/1078-0432.22450782.v1
Autor:
Kenneth C. Anderson, Rolf Lewensohn, Paul Richardson, Nikhil Munshi, Claudia Paba-Prada, Jack Spira, Kristina Viktorsson, Arghya Ray, Dharminder Chauhan
PDF file - 4200K, Supplementary Figure 1 (A) MM.1R and RPMI-8226 MM cells were treated with mel-flufen {1μM and 3μM, respectively} for 24h; protein lysates were subjected to immunoblotting using indicated antibodies. (B) MM1.R cells were treated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4664a142383a40271726c0d6ab22d26
https://doi.org/10.1158/1078-0432.22450788.v1
https://doi.org/10.1158/1078-0432.22450788.v1
Autor:
Kenneth C. Anderson, Rolf Lewensohn, Paul Richardson, Nikhil Munshi, Claudia Paba-Prada, Jack Spira, Kristina Viktorsson, Arghya Ray, Dharminder Chauhan
Purpose: The alkylating agent melphalan prolongs survival in patients with multiple myeloma; however, it is associated with toxicities and development of drug-resistance. Here, we evaluated the efficacy of melphalan-flufenamide (mel-flufen), a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043f5d243b76a4b14fe7ae82bde71b31
https://doi.org/10.1158/1078-0432.c.6522024.v1
https://doi.org/10.1158/1078-0432.c.6522024.v1
Autor:
Kenneth C. Anderson, Rolf Lewensohn, Paul Richardson, Nikhil Munshi, Claudia Paba-Prada, Jack Spira, Kristina Viktorsson, Arghya Ray, Dharminder Chauhan
PDF file - 281K, Supplementary Figure 2 MM.1S cells were treated with indicated concentrations of melphalan or mel-flufen for 4h. The cells were harvested and subjected to alkaline comet assay, and the fluorescent images were visualized (excitation/e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d03f0e6259525c159bcb45dbc91cf4b
https://doi.org/10.1158/1078-0432.22450785.v1
https://doi.org/10.1158/1078-0432.22450785.v1
Autor:
Mevludin Memedi, Adriana Miclescu, Lenka Katila, Marianne Claesson, Marie Essermark, Per Holm, Gunnar O. Klein, Jack Spira, Rolf Karlsten
Publikováno v:
Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering ISBN: 9783030991937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab288be7ab94f30077733291b50b0478
https://doi.org/10.1007/978-3-030-99194-4_7
https://doi.org/10.1007/978-3-030-99194-4_7
Autor:
Radu Constantinescu, Jerker Westin, Sten-Magnus Aquilonius, Alexander Medvedev, Jack Spira, Mevludin Memedi, Fredrik Ohlsson, Håkan Askmark, Anders Ericsson, Filip Bergquist, Marina Senek, Dag Nyholm, Sara Lycke
Publikováno v:
European Journal of Clinical Pharmacology
Background Motor function assessments with rating scales in relation to the pharmacokinetics of levodopa may increase the understanding of how to individualize and fine-tune treatments. Objectives This study aimed to investigate the pharmacokinetic p
Autor:
Dongni Johansson, Ilias Thomas, Jack Spira, Dag Nyholm, Filip Bergquist, Alexander Medvedev, Anders Johansson, Fredrik Ohlsson, Anders Ericsson, Mevludin Memedi, Marina Senek, Jerker Westin
Publikováno v:
Parkinsonismrelated disorders. 64
A treatment response objective index (TRIS) was previously developed based on sensor data from pronation-supination tests. This study aimed to examine the performance of TRIS for medication effects in a new population sample with Parkinson's disease
Autor:
Jack Spira, Joachim Gullbo, Peter Nygren, Anders Ullén, Magnus Ringbom, Hans Hagberg, Åke Berglund, Rolf Lewensohn, Karin Söderlind, Johan Harmenberg, Eva Nordström, Bengt Tholander, Alla Lisyanskaya, Markus Jerling, Carina Alvfors, Sergey Orlov
Publikováno v:
Investigational New Drugs. 33:1232-1241
Purpose Melflufen (melphalan flufenamide, previously designated J1) is an optimized and targeted derivative of melphalan, hydrolyzed by aminopeptidases overexpressed in tumor cells resulting in selective release and trapping of melphalan, and enhance
Publikováno v:
Clinical and experimental obstetricsgynecology. 44(3)
OBJECTIVE The objective was to evaluate the responsiveness of the Endometriosis Health Profile-30 (EHP-30) questionnaire in a Swedish sample. MATERIALS AND METHODS Forty-two patients with endometriosis were included in a prospective observational stu
Publikováno v:
Journal of Clinical Ultrasound. 43:81-88
Background To determine whether current hygiene practices are appropriate during sonographic examinations. Methods Five major hospitals in Sweden were investigated with a survey. At each hospital, the departments corresponding to the main types of so