Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Jack Sharkey"'
Autor:
Rachel Harwood, Joshua Bridge, Lorenzo Ressel, Lauren Scarfe, Jack Sharkey, Gabriela Czanner, Philip A Kalra, Aghogho Odudu, Simon Kenny, Bettina Wilm, Patricia Murray
Publikováno v:
Physiological Reports, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract Background Renal ischemia reperfusion injury (R‐IRI) can cause acute kidney injury (AKI) and chronic kidney disease (CKD), resulting in significant morbidity and mortality. To understand the underlying mechanisms, reproducible small‐anim
Externí odkaz:
https://doaj.org/article/81f06020f3294d19bf8396a38d095e7c
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0259608 (2022)
Propagation of small amyloid beta (Aβ) aggregates (or seeds) has been suggested as a potential mechanism of Alzheimer's disease progression. Monitoring the propagation of Aβ seeds in an organism would enable testing of this hypothesis and, if confi
Externí odkaz:
https://doaj.org/article/cdfc7bdff2454c67b76adbbc6f986702
Autor:
Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams, Harish Poptani, Brian K. Park, Patricia Murray, Bettina Wilm
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
Abstract Background Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and adverse events are oft
Externí odkaz:
https://doaj.org/article/90b861852cd94ace8b91583c61cbdcce
Autor:
Jack Sharkey, Lorenzo Ressel, Nathalie Brillant, Lauren Scarfe, Bettina Wilm, B. Kevin Park, Patricia Murray
Publikováno v:
Stem Cells International, Vol 2019 (2019)
Cell-based regenerative medicine therapies require robust preclinical safety, efficacy, biodistribution, and engraftment data prior to clinical testing. To address these challenges, we have developed an imaging toolbox comprising multispectral optoac
Externí odkaz:
https://doaj.org/article/bc3864b354b54c15b6c4cae4a2e1227e
Autor:
Joan Comenge, Jack Sharkey, Oihane Fragueiro, Bettina Wilm, Mathias Brust, Patricia Murray, Raphael Levy, Antonius Plagge
Publikováno v:
eLife, Vol 7 (2018)
Understanding the fate of exogenous cells after implantation is important for clinical applications. Preclinical studies allow imaging of cell location and survival. Labelling with nanoparticles enables high sensitivity detection, but cell division a
Externí odkaz:
https://doaj.org/article/19220c93753f4e67a2600814b62a7c35
Autor:
Sourav Bhaduri, Claire Louise Kelly, Clémentine Lesbats, Jack Sharkey, Lorenzo Ressel, Soham Mukherjee, Mark David Platt, Edward J. Delikatny, Harish Poptani
Publikováno v:
NMR in biomedicineREFERENCES.
Changes in glioblastoma (GBM) metabolism was investigated in response to JAS239, a choline kinase inhibitor, using MRS. In addition to the inhibition of phosphocholine synthesis, we investigated changes in other key metabolic pathways associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ea546203b8b79d932a473124e1bc9c
https://pubmed.ncbi.nlm.nih.gov/36269130
https://pubmed.ncbi.nlm.nih.gov/36269130
Autor:
Amy Schofield, Philip J. Starkey Lewis, Rhona Aird, Ian M. Copple, Fang Zhang, B. Kevin Park, Christopher E. Goldring, Tobias M Bunday, Stephen W. Fenwick, Yongxiang Fang, Shiva S. Forootan, Harish Poptani, Mohamed Elmasry, Emanuele Ricci, Hassan Malik, Jack Sharkey, Neil R. Kitteringham, Giusy Russomanno, Timothy Andrews, Nathalie Brillant, Benjamin K Y Chan, Adam Lister, Stuart J. Forbes, Rowena Sison-Young
Publikováno v:
Hepatology. 74:973-986
Background and aims The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates an array of cytoprotective genes, yet studies in transgenic mice have led to conflicting reports on its role in liver regeneration. We aimed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98017f1ca21c6bad68beb8f1132f63db
https://doi.org/10.1002/hep.31859
https://doi.org/10.1002/hep.31859
Autor:
Patricia Murray, Ulrike Wais, Yonghong Yang, Jack Sharkey, Haifei Zhang, Aidan Thomas, Claudia Fryer, Alexander W. Jackson, Bettina Wilm
Publikováno v:
ACS applied materials & interfaces
Noninvasive bioimaging techniques are critical for assessing the biodistribution of cellular therapies longitudinally. Among them, photoacoustic imaging (PAI) can generate high-resolution images with a tissue penetration depth of ∼4 cm. However, it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d288e43cd485aec6efa59e42070d56e
https://doi.org/10.1021/acsami.0c03857
https://doi.org/10.1021/acsami.0c03857
Autor:
Sourav Bhaduri, Clémentine Lesbats, Jack Sharkey, Claire Louise Kelly, Soham Mukherjee, Arthur Taylor, Edward J. Delikatny, Sungheon G. Kim, Harish Poptani
Publikováno v:
Cancers; Volume 14; Issue 5; Pages: 1223
To investigate the utility of DCE-MRI derived pharmacokinetic parameters in evaluating tumour haemodynamic heterogeneity and treatment response in rodent models of glioblastoma, imaging was performed on intracranial F98 and GL261 glioblastoma bearing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b13458e2fa7f6396c485a35e03a9b0
Propagation of small amyloid beta (Aβ) aggregates (or seeds) has been suggested as a potential mechanism of Alzheimer’s disease progression. Monitoring the propagation of Aβ seeds in an organism would enable testing of this hypothesis and, if con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c30202c0f490c2ecd0f9956cce926d
https://doi.org/10.1101/2021.10.25.465704
https://doi.org/10.1101/2021.10.25.465704
