Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Jack Satsangi"'
Autor:
Samira Salihovic, Niklas Nyström, Charlotte Bache-Wiig Mathisen, Robert Kruse, Christine Olbjørn, Svend Andersen, Alexandra J. Noble, Maria Dorn-Rasmussen, Igor Bazov, Gøri Perminow, Randi Opheim, Trond Espen Detlie, Gert Huppertz-Hauss, Charlotte R. H. Hedin, Marie Carlson, Lena Öhman, Maria K. Magnusson, Åsa V. Keita, Johan D. Söderholm, Mauro D’Amato, Matej Orešič, Vibeke Wewer, Jack Satsangi, Carl Mårten Lindqvist, Johan Burisch, Holm H. Uhlig, Dirk Repsilber, Tuulia Hyötyläinen, Marte Lie Høivik, Jonas Halfvarson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naï
Externí odkaz:
https://doaj.org/article/8a477108fc6e4a34a2cccb17d607374e
Autor:
Simone Dallari, Vicky Martinez Pazos, Juan Munoz Eusse, Judith Wellens, Craig Thompson, Jean-Frederic Colombel, Jack Satsangi, Ken Cadwell, Serre-Yu Wong, ICARUS-IBD Working Group
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract While differential antibody responses SARS-CoV-2 in patients with inflammatory bowel disease (IBD) receiving infliximab and vedolizumab are well-characterized, the immune pathways underlying these differences remain unknown. Prior to COVID-1
Externí odkaz:
https://doaj.org/article/d097121319674b2b89b25aece89b4326
Autor:
Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu, Jack Satsangi, Evropi Theodoratou, Xue Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking be
Externí odkaz:
https://doaj.org/article/04a74e10927f428d84730e560996c873
Autor:
Peter M Irving, Miles Parkes, Ruth Wood, Ailsa L Hart, Nicholas A Kennedy, Nick Powell, Julian R Marchesi, Tariq Ahmad, Tim Raine, Andrew King, James O Lindsay, Kevin Whelan, Charlie W Lees, Christopher A Lamb, Jack Satsangi, Emma Clark, Shriya Sharma, Xinyue Zhang, Christopher J Stewart, Naomi McGregor, Helen C Hancock, Rebecca H Maier, John C Mansfield, Mary Doona, Michelle Bardgett, Natalie J Prescott, Trevor Liddle, Robert Lees, Hannah Watson, Carl A Anderson, Ally Speight, Ciara Kennedy, Sarah Lawrence, Nicola J Wyatt, Jennifer A Doyle, Rebecca E McIntyre, Luke Jostins-Dean, Victoria Hildreth, James MS Wason, Dean Allerton, Dawn Clewes, Cristina Cotobal Martin, Katherine Frith, Sameena Iqbal, Laura Letchford, Jasmin Ostermayer, Tolulope Osunnuyi, Tara Shrestha, Michelle Strickland, Gregory R Young
Publikováno v:
BMJ Open, Vol 14, Iss 4 (2024)
Introduction Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient’s quality of life. Therapeutic developments
Externí odkaz:
https://doaj.org/article/12bb87e0caee4e31a4d86e9b0e5adbdd
Autor:
James O Lindsay, Daniel Hind, Lizzie Swaby, Hannah Berntsson, Mike Bradburn, Uday Bannur C, Jennifer Byrne, Christopher Clarke, Lauren Desoysa, Shahida Din, Richard Emsley, Gemma A Foulds, John Gribben, Christopher Hawkey, Peter M Irving, Peter Johnson, Majid Kazmi, Ellen Lee, Amanda Loban, Alan Lobo, Yashwant Mahida, Gordon Moran, Diana Papaioannou, Miles Parkes, Andrew Peniket, A Graham Pockley, Jack Satsangi, Sreedhar Subramanian, Simon Travis, Emily Turton, Ben Uttenthal, Sergio Rutella, John A Snowden
Publikováno v:
Efficacy and Mechanism Evaluation, Vol 11, Iss 03 (2024)
Some text in this abstract has been reproduced from Lindsay J, Din S, Hawkey C, Hind D, Irving P, Lobo A, et al. OFR-9 An RCT of autologous stem-cell transplantation in treatment refractory Crohn’s disease (low-intensity therapy evaluation): ASTICl
Externí odkaz:
https://doaj.org/article/dc34c6a6762e4f599cb3fa947e2a353d
Autor:
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)
Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me
Externí odkaz:
https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3
Autor:
Vincent Joustra, Andrew Y.F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D’Haens
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 869-885 (2023)
Background & Aims: There is great current interest in the potential application of DNA methylation alterations in peripheral blood leukocytes (PBLs) as biomarkers of susceptibility, progression, and treatment response in inflammatory bowel disease (I
Externí odkaz:
https://doaj.org/article/f4da3dfe0cbe411593eca99d4377a2f6
Autor:
Shiying Zhang, Xochitl Morgan, Belgin Dogan, Francois-Pierre Martin, Suzy Strickler, Akihiko Oka, Jeremy Herzog, Bo Liu, Scot E. Dowd, Curtis Huttenhower, Matthieu Pichaud, Esra I. Dogan, Jack Satsangi, Randy Longman, Rhonda Yantiss, Lukas A. Mueller, Ellen J. Scherl, R. Balfour Sartor, Kenneth W. Simpson
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Elucidating how resident enteric bacteria interact with their hosts to promote health or inflammation is of central importance to diarrheal and inflammatory bowel diseases across species. Here, we integrated the microbial and chemical microenvironmen
Externí odkaz:
https://doaj.org/article/c219403c4675442ebf44840ba6e8292c
Autor:
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Adult forms of inflammatory bowel disease (IBD) are of a polygenic nature, but paediatric and very early onset (VEO) IBD also occur as monogenic forms. Here, using whole exome sequencing, the authors explore both the monogenic and polygenic contribut
Externí odkaz:
https://doaj.org/article/2613668b99c441b1b30bfa2765e3a533
Autor:
Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Eli M Carrami, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/5c86d325bfef42dd9f9c9aa2ea68a8c9