Selective hydrogenation of nitro compounds to amines by coupled redox reactions over a heterogeneous biocatalyst

Autor: Daria Sokolova, Tara C. Lurshay, Jack S. Rowbotham, Georgia Stonadge, Holly A. Reeve, Sarah E. Cleary, Tim Sudmeier, Kylie A. Vincent

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)

Abstract Cleaner synthesis of amines remains a key challenge in organic chemistry because of their prevalence in pharmaceuticals, agrochemicals and synthetic building blocks. Here, we report a different paradigm for chemoselective hydrogenation of ni

Externí odkaz: https://doaj.org/article/8edcc78d71dd4cfc9cd2538d818cff90

Opening the Egg Box: NMR spectroscopic analysis of the interactions between s-block cations and kelp monosaccharides

Autor: H. Christopher Greenwell, Philip W. Dyer, Jack S. Rowbotham

Publikováno v: Rowbotham, J, Dyer, P W & Greenwell, H C 2021, ' Opening the Egg Box: NMR spectroscopic analysis of the interactions between s-block cations and kelp monosaccharides ', Dalton Transactions, vol. 50, no. 38, pp. 13246-13255 . https://doi.org/10.1039/d0dt04375c
Dalton Transactions, 2021, Vol.50(38), pp.13246-13255 [Peer Reviewed Journal]

The best-known theory accounting for metal-alginate complexation is the so-called "Egg Box"model. In order to gain greater insight into the metal-saccharide interactions that underpin this model, the coordination chemistry of the corresponding monome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d296adab4fc363f281bc4f13beb7fb6
https://doi.org/10.1039/d0dt04375c

The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase

Autor: Rhiannon M. Evans, Amelia Brasnett, Adam J. Healy, Kylie A. Vincent, Jack S. Rowbotham, Gianfelice Cinque, Ricardo Hidalgo, Philip A. Ash, Fraser A. Armstrong, Stephen B. Carr, Mark D. Frogley, Sophie E. T. Kendall-Price, Simone Morra

Publikováno v: Chemical Science
Ash, P A, Kendall-Price, S E T, Evans, R M, Carr, S B, Brasnett, A R, Morra, S, Rowbotham, J, Hidalgo, R, Cinque, G, Frogley, M D, Armstrong, F A & Vincent, K 2021, ' The crystalline state as a dynamic system: IR microspectroscopy under electrochemical control for a [NiFe] hydrogenase ', Chemical Science, vol. 12, no. 39, pp. 12959-12970 . https://doi.org/10.1039/d1sc01734a

Controlled formation of catalytically-relevant states within crystals of complex metalloenzymes represents a significant challenge to structure–function studies. Here we show how electrochemical control over single crystals of [NiFe] hydrogenase 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c127f5e49347962dfbe4f0160410c0b1
https://pubmed.ncbi.nlm.nih.gov/34745526

Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water

Autor: Kylie A. Vincent, Holly A. Reeve, Jack S. Rowbotham

Publikováno v: ACS Catalysis
Rowbotham, J, Reeve, H & Vincent, K 2021, ' Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water ', ACS Catalysis, vol. 11, no. 5, pp. 2596-2604 . https://doi.org/10.1021/acscatal.0c03437

Deuterium-labeled nicotinamide cofactors such as [4-2H]-NADH can be used as mechanistic probes in biological redox processes and offer a route to the synthesis of selectively [2H] labeled chemicals via biocatalytic reductive deuteration. Atom-efficie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db411fdbaa460ae1ab3f265f3fd1b05
https://pubmed.ncbi.nlm.nih.gov/33842020

Abstracts of the 28

Autor: Adam, Nelson, Robert J, Phipps, Georgie J, Crane, Niccolo A E, Venanzi, William J S, Lockley, Matthew, Tredwell, Niklaas J, Buurma, Andrew, Ballard, Hiwa O, Ahmad, Stefania, Narduolo, Lucy, Rosa, Nikki, Chand, David A, Cosgrove, Peter, Varkonyi, Nabil, Asaad, Simone, Tomasi, Andrew G, Leach, Nick, Summerhill, Jon, Bloom, Mark, Newby, Stephen, Madden, Daniela, Roman, Ruediger M, Exner, Fernando, Cortezon-Tamarit, Haobo, Ge, Stephen, Paisey, Sofia I, Pascu, Rafael T M, de Rosales, Helen C, Hailes, Yu, Wang, Jianxiong, Zhao, Daniel, Méndez-Sánchez, Rebecca, Rodan, Fabiana, Subrizi, Benjamin R, Lichman, Nicholas H, Keep, John M, Ward, Mark, Harris, Martin, Lamb, Vernon, Wilson, Peter, Iafrate, Flaviu, Bulat, Andre A, Néves, Friederike, Hesse, De-En, Hu, Franklin, Aigbirhio, Finian J, Leeper, Kevin M, Brindle, Jack S, Rowbotham, Koji, Urata, Holly A, Reeve, Kylie A, Vincent, Rebekka, Hueting

Publikováno v: Journal of labelled compoundsradiopharmaceuticals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::888e0cb67bcb7d60a1f8334b4209196a
https://pubmed.ncbi.nlm.nih.gov/32678462