Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Jack S. Cohen"'
Autor:
Jack S. Cohen, Barak Akabayov
Publikováno v:
Substantia (2024)
Antisense oligonucleotide (ASO) analogs have been used to counteract the effects of mutated genes and have been developed as therapeutic agents. Several such formulations have been subjected to clinical trials against cancer and have been passed by t
Externí odkaz:
https://doaj.org/article/4ced7448524a4e54b908df115ff5950d
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 527-535 (2021)
For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucle
Externí odkaz:
https://doaj.org/article/4ac471e96aa34296b13739df56727700
Autor:
Jack S. Cohen, Peter F. Daly
Publikováno v:
Substantia, Vol 6, Iss 1 (2022)
In the past 30 years there has been a significant increase in the number of publications on phospholipid (PL) metabolism, both for the medical purposes of detection and diagnosis of cancer and for the monitoring of the treatment of human cancers. Mos
Externí odkaz:
https://doaj.org/article/58cce8843a414d52b65104d606ef382c
Autor:
Jack S. Cohen
Publikováno v:
Substantia, Vol 5, Iss 1 (2021)
In the search for novel therapeutics, antisense oligonucleotide (ASO) analogs have been a major focus of research for over 40 years. They use the antisense strategy, namely they have a nucleic acid base sequence that is complementary to a portion of
Externí odkaz:
https://doaj.org/article/7baf92fcd90a40f4892038501dc29996
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 527-535 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
For antisense applications, oligonucleotides must be chemically modified to be resistant to endogenous nucleases. Until now, antisense oligonucleotide (ASO) analogs have been synthesized and then tested for their ability to duplex with a target nucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d5bc32dde27c6cc11cb563f2c41199
http://www.sciencedirect.com/science/article/pii/S2162253120303802
http://www.sciencedirect.com/science/article/pii/S2162253120303802
Autor:
Jack S. Cohen
America was the leader in industrial development and applied research at the beginning of the twentieth century. But the Federal Government felt it was inappropriate to spend the people's tax money to support basic research without any specific appli
Publikováno v:
Oncology Reports. 28:735-741
We aimed to determine the metabolic profile and effects of chemotherapy on ovarian cancer cell metabolism in a three-dimensional (3D) vs. a two-dimensional (2D) construct using 31P-magnetic resonance spectroscopy (MRS). Three ovarian cancer cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da1f6705a75cccc573784d472989f86
https://doi.org/10.3892/or.2012.1810
https://doi.org/10.3892/or.2012.1810
Autor:
Jack S. Cohen
Publikováno v:
Group Decision and Negotiation. 20:373-380
In this commentary it is suggested that understanding and hence resolution of the Middle East conflict between Israel and the Palestinian Arabs could be better served by considering it a tribal conflict.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0538b900382d1e6e097ed83db8270529
https://doi.org/10.1007/s10726-011-9240-z
https://doi.org/10.1007/s10726-011-9240-z
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778(10):2388-2394
article i nfo Nuclear Magnetic Resonance (NMR) spectroscopy was used to investigate the relationship between oxidative stress experienced by RBCs and their phospholipid content and shedding. Using 1 H-NMR, we demonstrated a higher lactate/pyruvate ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa280a02af449c5fe94af0a679521aa
Autor:
Jack S. Cohen, Yechezkel Barenholz, Victor M. Meidan, Yechezkel Sidi, Judith Glezer, Sharona Salomon, Gila Lilling
Publikováno v:
Journal of Liposome Research. 16:27-43
G3139 is an antisense oligonucleotide (ODN) that can down-regulate bcl-2, thus potentially acting as a potent anticancer drug. However, effective therapy requires efficient ODN delivery, which may be achieved by employing G3139 lipoplexes. Yet, lipof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94904aa7cf1f42c69af13cb3f793229
https://doi.org/10.1080/08982100500528685
https://doi.org/10.1080/08982100500528685