Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Jack S Richards"'
Autor:
Jo-Anne Chan, David Wetzel, Linda Reiling, Kazutoyo Miura, Damien R Drew, Paul R Gilson, David A Anderson, Jack S Richards, Carole A Long, Manfred Suckow, Volker Jenzelewski, Takafumi Tsuboi, Michelle J Boyle, Michael Piontek, James G Beeson
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221733 (2019)
The development of effective malaria vaccines remains a global health priority. Currently, the most advanced vaccine, known as RTS,S, has only shown modest efficacy in clinical trials. Thus, the development of more efficacious vaccines by improving t
Externí odkaz:
https://doaj.org/article/89f4de558b43477eaa92458ca4da6dc1
Autor:
David Wetzel, Jo-Anne Chan, Manfred Suckow, Andreas Barbian, Michael Weniger, Volker Jenzelewski, Linda Reiling, Jack S Richards, David A Anderson, Betty Kouskousis, Catherine Palmer, Eric Hanssen, Gerhard Schembecker, Juliane Merz, James G Beeson, Michael Piontek
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221394 (2019)
BACKGROUND:Malaria caused by Plasmodium falciparum is one of the major threats to human health globally. Despite huge efforts in malaria control and eradication, highly effective vaccines are urgently needed, including vaccines that can block malaria
Externí odkaz:
https://doaj.org/article/16530a1b9a194067a2d02bbdb2c34057
Autor:
Benedikt Ley, Mohammad Shafiul Alam, James J O'Donnell, Mohammad Sharif Hossain, Mohammad Golam Kibria, Nusrat Jahan, Wasif A Khan, Kamala Thriemer, Mark D Chatfield, Ric N Price, Jack S Richards
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169930 (2017)
Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based G6PD diagnostics to unsure safe use of primaquine.G6PD activities of partic
Externí odkaz:
https://doaj.org/article/926f61056d90439f94b441f6519a8b45
Autor:
Andrew J Guy, Vashti Irani, Christopher A MacRaild, Robin F Anders, Raymond S Norton, James G Beeson, Jack S Richards, Paul A Ramsland
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141729 (2015)
Malaria remains a significant global health burden. The development of an effective malaria vaccine remains as a major challenge with the potential to significantly reduce morbidity and mortality. While Plasmodium spp. have been shown to contain a la
Externí odkaz:
https://doaj.org/article/c7c5fab96dec4236ad0ea25ee3ede530
Autor:
Christopher A MacRaild, Milan Zachrdla, Dean Andrew, Bankala Krishnarjuna, Jiří Nováček, Lukáš Žídek, Vladimír Sklenář, Jack S Richards, James G Beeson, Robin F Anders, Raymond S Norton
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119899 (2015)
Merozoite surface protein 2 (MSP2) of Plasmodium falciparum is an abundant, intrinsically disordered protein that is GPI-anchored to the surface of the invasive blood stage of the malaria parasite. Recombinant MSP2 has been trialled as a component of
Externí odkaz:
https://doaj.org/article/6ccae8c4810c405e905cd97c80ea7865
Autor:
Linda Reiling, Jack S Richards, Freya J I Fowkes, Danny W Wilson, Watcharee Chokejindachai, Alyssa E Barry, Wai-Hong Tham, Janine Stubbs, Christine Langer, John Donelson, Pascal Michon, Livingstone Tavul, Brendan S Crabb, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45253 (2012)
BACKGROUND: Acquired antibodies are important in human immunity to malaria, but key targets remain largely unknown. Plasmodium falciparum reticulocyte-binding-homologue-4 (PfRh4) is important for invasion of human erythrocytes and may therefore be a
Externí odkaz:
https://doaj.org/article/e2507bd8a53d49268673d7b439fdb302
Autor:
James S McCarthy, Joanne Marjason, Suzanne Elliott, Paul Fahey, Gilles Bang, Elissa Malkin, Eveline Tierney, Hayley Aked-Hurditch, Christopher Adda, Nadia Cross, Jack S Richards, Freya J I Fowkes, Michelle J Boyle, Carole Long, Pierre Druilhe, James G Beeson, Robin F Anders
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24413 (2011)
In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately
Externí odkaz:
https://doaj.org/article/48362a580ee849fd841b7e69abb62ab8
Publikováno v:
PLoS Medicine, Vol 8, Iss 2, p e1000410 (2011)
Externí odkaz:
https://doaj.org/article/2bdfbbd01df1402da099fc947abcc89f
Publikováno v:
PLoS Medicine, Vol 7, Iss 1, p e1000218 (2010)
BACKGROUND: One of the criteria to objectively prioritize merozoite antigens for malaria vaccine development is the demonstration that naturally acquired antibodies are associated with protection from malaria. However, published evidence of the prote
Externí odkaz:
https://doaj.org/article/732b51ef39dd44f8a0ef6a7f3f06bac1
Autor:
Fiona J McCallum, Kristina E M Persson, Cleopatra K Mugyenyi, Freya J I Fowkes, Julie A Simpson, Jack S Richards, Thomas N Williams, Kevin Marsh, James G Beeson
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3571 (2008)
BACKGROUND:Antibodies that inhibit the growth of blood-stage Plasmodium falciparum may play an important role in acquired and vaccine-induced immunity in humans. However, the acquisition and activity of these antibodies is not well understood. METHOD
Externí odkaz:
https://doaj.org/article/9228bdf05e474d6a801902d1cd49e467