Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Jack Rosenbluth"'
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 433-437 (2009)
Conditional inactivation of the ‘neuropathy target esterase’ (NTE) gene in mouse nerve cells was previously shown to result in CNS pathology comparable to the spongiform encephalopathy characteristic of prion diseases. To determine whether cellul
Externí odkaz:
https://doaj.org/article/0f620cf07c204a59ae1f84c768e4e203
Autor:
Florence Chaverneff, Maren Ketcham, Amanda J. Mierzwa, Eric J. Lang, Michael Weinstock, Jack Rosenbluth
Publikováno v:
Journal of Comparative Neurology. 523:197-208
The new mutant mouse shaking (shk) differs from other “myelin mutants” in having a more stable neurological impairment and a much longer lifespan. We have shown that transverse bands (TBs), the component of the paranodal junction (PNJ) that attac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0afb15ce42ad517b0514d508be18b358
https://doi.org/10.1002/cne.23670
https://doi.org/10.1002/cne.23670
Publikováno v:
Journal of Neuroscience Research. 92:476-485
Subtle defects in paranodes of myelinated nerve fibers can cause significant physiological malfunction. We have investigated myelinated fibers in the peripheral nervous system (PNS) of the Trembler mouse, a model of CMT-1A neuropathy, for evidence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7550c151c80fda18a313b86f292501d6
https://doi.org/10.1002/jnr.23326
https://doi.org/10.1002/jnr.23326
Publikováno v:
Journal of Neuroscience Research. 91:374-381
The dysmyelinating mouse mutant quaking (qk) is thought to be a model of schizophrenia based on diminution of CNS myelin (Andreone et al., 2007) and downregulation of the Qk gene (Haroutunian et al., 2006) in the brains of schizophrenic patients. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bd58529bcf0307cfe0048f5fcf553f
https://doi.org/10.1002/jnr.23167
https://doi.org/10.1002/jnr.23167
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 433-437 (2009)
Conditional inactivation of the ‘neuropathy target esterase’ (NTE) gene in mouse nerve cells was previously shown to result in CNS pathology comparable to the spongiform encephalopathy characteristic of prion diseases. To determine whether cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dd3a5a22643bd8441d3a709cfad66e
https://doi.org/10.1016/j.nbd.2009.06.001
https://doi.org/10.1016/j.nbd.2009.06.001
Publikováno v:
Glia. 53:372-381
Galactocerebroside (GalC) and sulfatide are abundant myelin lipids. In mice incapable of synthesizing these lipids, myelin is thin and regionally unstable and exhibits several subtle structural abnormalities. Although galactolipid-null mice have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738b4da30f9925f381f3bffc672e38e9
https://doi.org/10.1002/glia.20292
https://doi.org/10.1002/glia.20292
Publikováno v:
Glia. 54:172-182
This study explores subtle defects in the myelin of proteolipid protein (PLP)-null mice that could potentially underlie the functional losses and axon damage known to occur in this mutant and in myelin diseases including multiple sclerosis. We have c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602277c64c17e0b6a658a0e277423624
https://doi.org/10.1002/glia.20370
https://doi.org/10.1002/glia.20370
Autor:
Moses V. Chao, Brian Malester, Jixiang Xu, Lino Tessarollo, Katerina Akassoglou, Jack Rosenbluth
Publikováno v:
Proceedings of the National Academy of Sciences. 101:5075-5080
Neuropathy target esterase (NTE) is a neuronal membrane protein originally identified for its property to be modified by organo-phosphates (OPs), which in humans cause neuropathy characterized by axonal degeneration. Drosophila mutants for the homolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e546d6f65a6af59e2a3c1b091b094dfb
https://doi.org/10.1073/pnas.0401030101
https://doi.org/10.1073/pnas.0401030101
Publikováno v:
Journal of Neurocytology. 32:265-276
We showed previously that spinal cord implants of hybridoma cells (O1) that secrete an IgM antigalactocerebroside cause focal multiple-sclerosis-like plaques of demyelination followed by remyelination to form "shadow plaques" (Rosenbluth et al., 1999
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a140cfd212c1fcee1a30dfd0467372a
https://doi.org/10.1023/b:neur.0000010085.91976.a6
https://doi.org/10.1023/b:neur.0000010085.91976.a6
Autor:
Wolfgang Brueck, Jack Rosenbluth, Glaucia C. Furtado, Joseph D. Buxbaum, Moses V. Chao, Joseph Schlessinger, Juan J. Lafaille, Sheila Harroch
Publikováno v:
Nature Genetics. 32:411-414
Several lines of evidence suggest that tyrosine phosphorylation is a key element in myelin formation, differentiation of oligodendrocytes and Schwann cells, and recovery from demyelinating lesions. Multiple sclerosis is a demyelinating disease of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81458da69034f53a7d7af2a4cd6b6f36
https://doi.org/10.1038/ng1004
https://doi.org/10.1038/ng1004