Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jack Peter Green"'
Autor:
Alison E. Mather, Jack Rivers-Auty, Harry G. Spence, Christopher Hoyle, Michael J.D. Daniels, Shi Yu, Margaret Jane Gordon, James Cook, David Brough, Paul T. Kennedy, John H. Beattie, Amy Bradley, Victor S. Tapia, Ruth Peters, Samuel Drinkall, Te-Chen Tzeng, Claire S. White, Catherine B. Lawrence, Jack Peter Green
Publikováno v:
The Journal of Neuroscience
Alzheimer's disease is a devastating neurodegenerative disease with a dramatically increasing prevalence and no disease-modifying treatment. Inflammatory lifestyle factors increase the risk of developing Alzheimer's disease. Zinc deficiency is the mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7018a3cbf7c3fb7a28bf046d53d9335
http://europepmc.org/articles/PMC8018890
http://europepmc.org/articles/PMC8018890
Autor:
Stephane de Cesco, Daniel Williams, Lucy V Morris, Lina Y El-Sharkawy, Tessa Swanton, Halah Hammadi, Catherine B. Lawrence, Jack Peter Green, David Brough, Shi Yu, Sally Freeman, James A Beswick, John B. Davis
Publikováno v:
Swanton, T, Beswick, J, Hammadi, H, Morris, L, Williams, D, De Cesco, S, El-sharkawy, L, Yu, S, Green, J, Davis, J, Lawrence, C, Brough, D & Freeman, S 2020, ' Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl-channel modulation ', Chemical Science, vol. 11, no. 43, pp. 11720-11728 . https://doi.org/10.1039/D0SC03828H
Chemical Science
Chemical Science
The NLRP3 inflammasome regulates production of the pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18, and contributes to inflammation exacerbating disease. Fenamate non-steroidal anti-inflammatory drugs (NSAIDs) were recently described as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3a8b9179397a434db4dd5074272628
https://doi.org/10.1039/d0sc03828h
https://doi.org/10.1039/d0sc03828h
Autor:
David Brough, Rose Wellens, Jack Peter Green, Fátima Martín-Sánchez, Bali Lee, Martin Lowe, Hayley M. Bennett, Paula I. Seoane, Daniel Williams, Gloria Lopez-Castejon, Antony Adamson, Christopher Hoyle
Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and with a poorly defined regulation by sub-cellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::846b12033a4b6b8e76892bee79973ee9
https://doi.org/10.1101/2021.09.15.460426
https://doi.org/10.1101/2021.09.15.460426
Autor:
Antony Adamson, Tessa Swanton, Catherine B. Lawrence, Shi Yu, Richard A. Bryce, Sally Freeman, David Brough, Lina Y El-Sharkawy, Jack Peter Green, Lucy V Morris, James Cook, James A Beswick, Neil E. Humphreys
Publikováno v:
eLife
eLife, Vol 9 (2020)
Green, J, Swanton, T, Morris, L, El-Sharkawy, L, Cook, J, Yu Shi, A, Beswick, J, Adamson, A, Humphreys, N, Bryce, R, Freeman, S, Lawrence, C B & Brough, D 2020, ' LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ', eLife, vol. 2020, no. 9, e59704 . https://doi.org/10.7554/eLife.59704
eLife, Vol 9 (2020)
Green, J, Swanton, T, Morris, L, El-Sharkawy, L, Cook, J, Yu Shi, A, Beswick, J, Adamson, A, Humphreys, N, Bryce, R, Freeman, S, Lawrence, C B & Brough, D 2020, ' LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ', eLife, vol. 2020, no. 9, e59704 . https://doi.org/10.7554/eLife.59704
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a230cebaafbd78209469337b11d79a9
https://doi.org/10.7554/elife.59704
https://doi.org/10.7554/elife.59704
Publikováno v:
Yu Shi, A, Green, J, Wellens, R, Lopez-Castejon, G & Brough, D 2020, ' Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification ', The FEBS Journal . https://doi.org/10.1111/febs.15619
The Febs Journal
The Febs Journal
The NLRP3 inflammasome drives inflammation in response to tissue damage and infection by promoting the processing and release of IL‐1β. Human monocytes have an alternative pathway of NLRP3 inflammasome activation in response to lipopolysaccharide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8550ab8a7d10f51c73cfc6bcc1d6f798
https://www.research.manchester.ac.uk/portal/en/publications/bafilomycin-a1-enhances-nlrp3-inflammasome-activation-in-human-monocytes-independent-of-lysosomal-acidification(e30a3d35-1c23-4f32-acab-48f919b65619).html
https://www.research.manchester.ac.uk/portal/en/publications/bafilomycin-a1-enhances-nlrp3-inflammasome-activation-in-human-monocytes-independent-of-lysosomal-acidification(e30a3d35-1c23-4f32-acab-48f919b65619).html
Autor:
Shi Yu, Sally Freeman, James Cook, Neil E. Humphreys, Richard A. Bryce, James A Beswick, David Brough, Antony Adamson, Tessa Swanton, Jack Peter Green, Lucy V Morris, Catherine E. Lawrence, Lina Y El-Sharkawy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8d6287f405f4cfcf90a9e2e65d6d9a7
https://doi.org/10.7554/elife.59704.sa2
https://doi.org/10.7554/elife.59704.sa2
Publikováno v:
Cytokine & Growth Factor Reviews
Graphical abstract
Highlights • The process of aging is associated with chronic inflammation termed inflammaging. • Inflammaging drives a number of age related diseases. • Biochemical changes driven by aging prime NLRP3 inflammasomes trans
Highlights • The process of aging is associated with chronic inflammation termed inflammaging. • Inflammaging drives a number of age related diseases. • Biochemical changes driven by aging prime NLRP3 inflammasomes trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3045cf2bac16ce14ad46279ea742eb
https://pubmed.ncbi.nlm.nih.gov/32883606
https://pubmed.ncbi.nlm.nih.gov/32883606
Autor:
Neil E. Humphreys, James A Beswick, James Cook, Tessa Swanton, Jack Peter Green, Catherine E. Lawrence, Lina Y El-Sharkawy, Antony Adamson, Shi Yu, Sally Freeman, Lucy V Morris, David Brough, Richard A. Bryce
The NLRP3 inflammasome is a multi-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1β and IL-18. The NLRP3 inflammasome is frequently associated with the damaging inflammation of non-communicable disease s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b251bb08e1c5c41a5e21fa0b789ddfe
https://doi.org/10.1101/2020.06.11.146225
https://doi.org/10.1101/2020.06.11.146225
Autor:
David Brough, Pablo Pelegrín, Shi Yu, Gloria Lopez-Castejon, Catherine B. Lawrence, Fátima Martín-Sánchez, Jack Peter Green
Publikováno v:
Green, J, Yu, S, Martín-Sánchez, F, Pelegrin, P, Lopez-Castejon, G, Lawrence, C B & Brough, D 2018, ' Chloride regulates dynamic NLRP3-dependent ASC oligomerisation and inflammasome priming ', Proceedings of the National Academy of Sciences, vol. 115, no. 40, pp. E9371-E9380 . https://doi.org/10.1073/pnas.1812744115
The NLRP3 inflammasome is an important regulator of inflammation and immunity. It is a multimolecular platform formed within cells that facilitates the activation of proinflammatory caspases to drive secretion of cytokines such as interleukin-1β (IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36dab219cc2b9e49dba7dcef19c4178b
https://doi.org/10.1073/pnas.1812744115
https://doi.org/10.1073/pnas.1812744115
Autor:
Carl L. Johnson, Jack Peter Green
Publikováno v:
International Journal of Quantum Chemistry. 8:159-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4bef06532c756fd1a628fe2b633341e
https://doi.org/10.1002/qua.560080720
https://doi.org/10.1002/qua.560080720