Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolismResearch in context

Autor: Marcus C.B. Tan, Chelsea A. Isom, Yangzi Liu, David-Alexandre Trégouët, Lang Wu, Dan Zhou, Eric R. Gamazon, Sara Lindstrom, Lu Wang, Erin Smith, William Gordon, Astrid Van Hylckama Vlieg, Mariza De Andrade, Jennifer Brody, Jack Pattee, Jeffrey Haessler, Ben Brumpton, Daniel Chasman, Pierre Suchon, Ming-Huei Chen, Constance Turman, Marine Germain, Kerri Wiggins, James MacDonald, Sigrid Braekkan, Sebastian Armasu, Nathan Pankratz, Rabecca Jackson, Jonas Nielsen, Franco Giulianini, Marja Puurunen, Manal Ibrahim, Susan Heckbert, Theo Bammler, Kelly Frazer, Bryan McCauley, Kent Taylor, James Pankow, Alexander Reiner, Maiken Gabrielsen, Jean-François Deleuze, Chris O'Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John-Bjarne Hansen, Frits Rosendaal, John Heit, Bruce Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul Ridker, Pierre-Emmanuel Morange, Andrew Johnson, Christopher Kabrhel, Nicholas Smith

Publikováno v: EBioMedicine, Vol 106, Iss , Pp 105233- (2024)

Summary: Background: Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence the incidence of this cancer; and 2. Whether PDAC causally predisposes to associated non-malignan

Externí odkaz: https://doaj.org/article/3420f9e9c9f34b658ac5d3b0471a4072

Using electronic health records to enhance surveillance of diabetes in children, adolescents and young adults: a study protocol for the DiCAYA Network

Autor: Hui Zhou, Manmohan Kamboj, Yi Guo, Angela D Liese, Rebecca Anthopolos, Lu Zhang, John Chang, Anna Roberts, Tessa Crume, Brian E Dixon, Hui Shao, David C Lee, Lorna E Thorpe, Dimitri Christakis, Eneida A Mendonca, Katie Allen, Dana Dabelea, Giuseppina Imperatore, Mark Weiner, Meredith Akerman, Rong Wei, Kristi Reynolds, Annemarie G Hirsch, Jasmin Divers, Tianchen Lyu, Alex Ewing, Shaun Grannis, Yuan Luo, Bo Cai, Anthony Wong, Brian S Schwartz, Meda Pavkov, Meredith Lewis, Sarah Conderino, Jiang Bian, Yonghui Wu, Jihad S Obeid, Harold P Lehmann, Charles Bailey, Theresa Anderson, Elizabeth A Shenkman, Elizabeth Nauman, Christopher Forrest, Mattia Prosperi, Seho Park, Cara M Nordberg, Tessa L Crume, Anna Bellatorre, Stefanie Bendik, Marc Rosenman, Levon Utidjian, Mitch Maltenfort, Amy Shah, G Todd Alonso, Sara Deakyne-Davies, Tim Bunnell, Anne Kazak, Melody Kitzmiller, Daksha Ranade, Joseph J DeWalle, H Lester Kirchner, Dione G Mercer, Amy Poissant, Nimish Valvi, Jeff Warvel, Ashley Wiensch, Tamara Hannon, Eva Lustigova, Don McCarthy, Matthew T Mefford, George Lales, Allison Zelinski, Pedro Rivera, Thomas Carton, Victor W Zhong, Andrew Fair, Jessica Guillaume, Shahidul Islam, Alan Jacobson, Chinyere Okpara, Anand Rajan, Andrea Titus, Rebecca Conway, Toan Ong, Jack Pattee, Shawna Burgett, Bethlehem Shiferaw, Sarah J Bost, William T Donahoo, William R Hogan, Piaopiao Li, Lisa Knight, Caroline Rudisill, Jessica Stucker, Deborah Bowlby, Elaine Apperson, Deborah B Rolka

Publikováno v: BMJ Open, Vol 14, Iss 1 (2024)

Introduction Traditional survey-based surveillance is costly, limited in its ability to distinguish diabetes types and time-consuming, resulting in reporting delays. The Diabetes in Children, Adolescents and Young Adults (DiCAYA) Network seeks to adv

Externí odkaz: https://doaj.org/article/8ca915a32dcd4ffdbd2dee2faf1c3e56

Hyperoxemia During Cardiac Surgery Is Associated With Postoperative Pulmonary Complications

Autor: David J. Douin, MD, Jack Pattee, PhD, Benjamin Scott, MD, Ana Fernandez-Bustamante, MD, PhD, Meghan Prin, MD, MS, Tobias Eckle, MD, PhD, Adit A. Ginde, MD, MPH, Nathan Clendenen, MD, MS

Publikováno v: Critical Care Explorations, Vol 5, Iss 3, p e0878 (2023)

OBJECTIVES:. The use of hyperoxemia during cardiac surgery remains controversial. We hypothesized that intraoperative hyperoxemia during cardiac surgery is associated with an increased risk of postoperative pulmonary complications. DESIGN:. Retrospec

Externí odkaz: https://doaj.org/article/a2aa1c346d2c4e4bb99e06b2f698d811

Time-of-day dependent effects of midazolam administration on myocardial injury in non-cardiac surgery

Autor: Meghan Prin, Jack Pattee, David J. Douin, Benjamin K. Scott, Adit A. Ginde, Tobias Eckle

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundAnimal studies have shown that midazolam can increase vulnerability to cardiac ischemia, potentially via circadian-mediated mechanisms. We hypothesized that perioperative midazolam administration is associated with an increased incidence of

Externí odkaz: https://doaj.org/article/9dacd9d4242a4c71be938e6dfcf90c5b

Penalized regression and model selection methods for polygenic scores on summary statistics.

Autor: Jack Pattee, Wei Pan

Publikováno v: PLoS Computational Biology, Vol 16, Iss 10, p e1008271 (2020)

Polygenic scores quantify the genetic risk associated with a given phenotype and are widely used to predict the risk of complex diseases. There has been recent interest in developing methods to construct polygenic risk scores using summary statistic

Externí odkaz: https://doaj.org/article/dcfad8ea8fb24fba8fd05b02399ae9f2