Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Jack P. Higgins"'
Autor:
Daniel O. Persky, Jack P. Higgins, Banmeet S. Anand, Eric T. Williams, Thomas Strack, Kristina Dabovic, Christine Burnett, Steven I. Park, Vasile Musteata, Paul A. Hamlin
Supplementary Table 1. Additional Study Eligibility Criteria. Supplementary Table 2. Pharmacokinetic Serum Sample Collection. Supplementary Table 3. Summary of Adverse Events and Discontinuations. Supplementary Table 4. Summary of Serum MT-3724 PK Pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e8eb3a182d2381d2a0f99c3e33c520
https://doi.org/10.1158/2767-9764.22544535.v1
https://doi.org/10.1158/2767-9764.22544535.v1
Autor:
Daniel O. Persky, Jack P. Higgins, Banmeet S. Anand, Eric T. Williams, Thomas Strack, Kristina Dabovic, Christine Burnett, Steven I. Park, Vasile Musteata, Paul A. Hamlin
MT-3724, a novel engineered toxin body comprised of an anti-CD20 single-chain variable fragment genetically fused to Shiga-like Toxin A subunit, is capable of binding to and internalizing against CD20, inducing cell killing via permanent ribosomal in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cc7aa635f71b1ffab59651a623b580
https://doi.org/10.1158/2767-9764.c.6550680.v1
https://doi.org/10.1158/2767-9764.c.6550680.v1
Autor:
Jeffrey Schlom, William L. Dahut, Herbert Kotz, Seth M. Steinberg, James W. Hodge, Jack P. Higgins, Mary P. Pazdur, Jacquin L. Jones, Vittore Cereda, Cinzia Remondo, Diane J. Poole, Claudia Palena, Junko Yokokawa, Kwong-Yok Tsang, Philip M. Arlen, James L. Gulley
Supplementary Data from Pilot Study of Vaccination with Recombinant CEA-MUC-1-TRICOM Poxviral-Based Vaccines in Patients with Metastatic Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c8af7ecc80a59b46abf061226ce87d
https://doi.org/10.1158/1078-0432.22439665
https://doi.org/10.1158/1078-0432.22439665
Autor:
David S. Hong, Michael A. Curran, Kimal Rajapakshe, Ly M. Nguyen, Di Nguyen, Hira Zain, Elizabeth Sumner, Funda Meric-Bernstam, JoAnn Lim, Thomas F. Wilson, Eric T. Williams, Jack P. Higgins, Cristian Coarfa, Priya Bhosale, Vivek Subbiah, Timothy A. Yap, Ecaterina E. Dumbrava, Siqing Fu, Shubham Pant, Jordi Rodon, Daniel Karp, Sarina Piha-Paul, Coline A. Couillault, Priyamvada Jayaprakash, Aparna Hegde
Compilation of supplemental tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b735def399b806d88f9c72e98f39df
https://doi.org/10.1158/1078-0432.22479855.v1
https://doi.org/10.1158/1078-0432.22479855.v1
Autor:
Jeffrey Schlom, William L. Dahut, Herbert Kotz, Seth M. Steinberg, James W. Hodge, Jack P. Higgins, Mary P. Pazdur, Jacquin L. Jones, Vittore Cereda, Cinzia Remondo, Diane J. Poole, Claudia Palena, Junko Yokokawa, Kwong-Yok Tsang, Philip M. Arlen, James L. Gulley
Purpose: Poxviral vectors have a proven safety record and can be used to incorporate multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic tolerance to self-antigens can be broken. Carcinoembryonic antigen (CEA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7595bd0013f69f6f354aaba2b0cfaa92
https://doi.org/10.1158/1078-0432.c.6517102
https://doi.org/10.1158/1078-0432.c.6517102
Autor:
David S. Hong, Michael A. Curran, Kimal Rajapakshe, Ly M. Nguyen, Di Nguyen, Hira Zain, Elizabeth Sumner, Funda Meric-Bernstam, JoAnn Lim, Thomas F. Wilson, Eric T. Williams, Jack P. Higgins, Cristian Coarfa, Priya Bhosale, Vivek Subbiah, Timothy A. Yap, Ecaterina E. Dumbrava, Siqing Fu, Shubham Pant, Jordi Rodon, Daniel Karp, Sarina Piha-Paul, Coline A. Couillault, Priyamvada Jayaprakash, Aparna Hegde
Purpose:As hypoxia can mediate resistance to immunotherapy, we investigated the safety, tolerability, and efficacy of combining evofosfamide, a prodrug that alleviates hypoxia, with ipilimumab, an immune checkpoint inhibitor, in immunologically “co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86672c133a9002c5ca5f7cc49d4f510c
https://doi.org/10.1158/1078-0432.c.6530310
https://doi.org/10.1158/1078-0432.c.6530310
Autor:
Paul A. Hamlin, Vasile Musteata, Steven I. Park, Christine Burnett, Kristina Dabovic, Thomas Strack, Eric T. Williams, Banmeet S. Anand, Jack P. Higgins, Daniel O. Persky
Publikováno v:
Cancer Research Communications. 2:307-315
MT-3724, a novel engineered toxin body comprised of an anti-CD20 single-chain variable fragment genetically fused to Shiga-like Toxin A subunit, is capable of binding to and internalizing against CD20, inducing cell killing via permanent ribosomal in
Autor:
Jordi Rodon, Joann Lim, Elizabeth A. Sumner, Hira Zain, Di Nguyen, Jack P. Higgins, Vivek Subbiah, Funda Meric-Bernstam, Eric T Williams, Coline Agnes Couillault, Siqing Fu, Timothy A. Yap, Kimal Rajapakshe, Aparna Hegde, Sarina Anne Piha-Paul, Shubham Pant, Michael A. Curran, Priya Bhosale, Priyamvada Jayaprakash, David S. Hong, Thomas F. Wilson, Daniel D. Karp, Ecaterina Ileana Dumbrava, Ly M. Nguyen, Cristian Coarfa
Publikováno v:
Clin Cancer Res
Purpose: As hypoxia can mediate resistance to immunotherapy, we investigated the safety, tolerability, and efficacy of combining evofosfamide, a prodrug that alleviates hypoxia, with ipilimumab, an immune checkpoint inhibitor, in immunologically “c
Autor:
Eric T Williams, Roger J. Waltzman, Jack P. Higgins, Asis K. Sarkar, Aimee Iberg, Erin Willert
Publikováno v:
Cancer Research. 80:P1-18
Engineered toxin bodies (ETBs) are differentiated, targeted therapeutics comprised of a proprietarily engineered form of Shiga-like Toxin A subunit (SLTA) genetically fused to antibody-like binding domains. ETBs work through novel mechanisms of actio
Autor:
Sofia R Gameiro, Jack P Higgins, Matthew R Dreher, David L Woods, Goutham Reddy, Bradford J Wood, Chandan Guha, James W Hodge
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70417 (2013)
Radiofrequency ablation (RFA) is a minimally invasive energy delivery technique increasingly used for focal therapy to eradicate localized disease. RFA-induced tumor-cell necrosis generates an immunogenic source of tumor antigens known to induce anti
Externí odkaz:
https://doaj.org/article/43c2f3ab680b4855918e40a19cb0b99e