Zobrazeno 1 - 10
of 484
pro vyhledávání: '"Jack P, Antel"'
Autor:
Afsaneh Shirani, Nil Saez-Calveras, Jack P. Antel, Moein Yaqubi, Wayne Moore, Amy L. Brewster, Olaf Stuve
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Multiple lines of evidence suggest a role of inflammation in epilepsy. Seizure incidence in patients with multiple sclerosis (MS) is twofold to threefold higher than the age-matched general population. Objectives: To explore the associati
Externí odkaz:
https://doaj.org/article/8935f835fd054892b36d48d14c69d1c2
Autor:
Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy W. R. Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on colony-stimulating fac
Externí odkaz:
https://doaj.org/article/aa6be16cdc4045c0b1747096bb52aa8a
Autor:
Florian Pernin, Qiao-Ling Cui, Abdulshakour Mohammadnia, Milton G. F. Fernandes, Jeffery A. Hall, Myriam Srour, Roy W. R. Dudley, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Hannah E. Salapa, Michael C. Levin, G. R. Wayne Moore, Timothy E. Kennedy, Christine Vande Velde, Jack P. Antel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular re
Externí odkaz:
https://doaj.org/article/7ecd4f332096485d86164c4aeb9e24fc
Autor:
Chao Weng, Adam M.R. Groh, Moein Yaqubi, Qiao-Ling Cui, Jo Anne Stratton, G. R. Wayne Moore, Jack P. Antel
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1336-1349 (2025)
Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system. Recent evidence has challenged the classical view of the functionally static mature oligodendroc
Externí odkaz:
https://doaj.org/article/e0be70ed53e9484c8f42390661cc299e
Autor:
Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, Florian Pernin, Laura Eleonora Schmitz-Gielsdorf, Caroline Hodgins, Qiao-Ling Cui, Moein Yaqubi, Manon Blain, Jeffery Hall, Roy Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Jo Anne Stratton, Moses Rodriguez, Tanja Kuhlmann, Wayne Moore, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss include metabolic stress within the lesion microenvironment. Here we use the injury response of pr
Externí odkaz:
https://doaj.org/article/0b83309164e245e4aea64f44e59886dc
Autor:
Hanane Touil, Rui Li, Leah Zuroff, Craig S. Moore, Luke Healy, Francesca Cignarella, Laura Piccio, Samuel Ludwin, Alexandre Prat, Jennifer Gommerman, Frederick C. Bennett, Dina Jacobs, Joyce A. Benjamins, Robert P. Lisak, Jack P. Antel, Amit Bar-Or
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104789- (2023)
Summary: Background: B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized as important contributors to progressive disease. This subpial
Externí odkaz:
https://doaj.org/article/7c524e1075d448d58fba5b49832be3e8
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
In this Perspective, Molina-Gonzalez and co-authors discuss the contribution of oligodendrocyte injury to neurological disease and the potential for their therapeutic targeting.
Externí odkaz:
https://doaj.org/article/b7fc68b702154cb9baea4808e0c3feb5
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Multiple sclerosis (MS) is an autoimmune disease of the CNS, featuring inflammation and demyelination with variable recovery. In this issue of the JCI, Kapell, Fazio, and authors address the potential for targeting neuron-oligodendrocyte potassium sh
Externí odkaz:
https://doaj.org/article/1fb134ff23f441dfa3644c7eade8f1c0
Autor:
Milton Guilherme Forestieri Fernandes, Julia Xiao Xuan Luo, Qiao-Ling Cui, Kelly Perlman, Florian Pernin, Moein Yaqubi, Jeffery A. Hall, Roy Dudley, Myriam Srour, Charles P. Couturier, Kevin Petrecca, Catherine Larochelle, Luke M. Healy, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myeli
Externí odkaz:
https://doaj.org/article/2f5ecb99de5f4c29b216220d02b72b5a
Autor:
Anastasia Manousi, Peter Göttle, Laura Reiche, Qiao-Ling Cui, Luke M. Healy, Rainer Akkermann, Joel Gruchot, Jessica Schira-Heinen, Jack P. Antel, Hans-Peter Hartung, Patrick Küry
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103276- (2021)
Background: In multiple sclerosis loss of myelin and oligodendrocytes impairs saltatory signal transduction and leads to neuronal loss and functional deficits. Limited capacity of oligodendroglial precursor cells to differentiate into mature cells is
Externí odkaz:
https://doaj.org/article/9b72cff1c316473b8a459bd24a1622c0