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Ultrathick Boron Carbide Coatings for Nuclear Fusion Targets

Autor: Swanee J. Shin, Leonardus B. Bayu Aji, Alison M. Engwall, John H. Bae, Gregory V. Taylor, Paul B. Mirkarimi, Chantel Aracne-Ruddle, Jack Nguyen, Casey W. N. Kong, Sergei O. Kucheyev

Boron carbide is an attractive ablator for next-generation inertial confinement fusion (ICF) targets. Here we describe several aspects of our ongoing systematic studies of the deposition and processing of B4C coatings for ICF targets. We show that re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5578da633a2c580ba5cc8c37b9f6ce78

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Pharmacokinetics of ADS-5102 (Amantadine) Extended Release Capsules Administered Once Daily at Bedtime for the Treatment of Dyskinesia

Autor: Gregory T. Went, Reed Johnson, Rajesh Pahwa, Robert A. Hauser, William Wargin, Natalie McClure, Rajiv Patni, Cindy J. Souza-Prien, Jack Nguyen

Publikováno v: Clinical Pharmacokinetics

Background Preclinical and clinical studies suggest amantadine immediate-release (IR) may reduce dyskinesia in Parkinson’s disease (PD), although higher doses are associated with increased CNS adverse events (AEs). ADS-5102 is an extended release a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66868367256c41c2052deb046dec9ec9
https://doi.org/10.1007/s40262-018-0663-4

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Amantadine Improves Cognitive Outcome and Increases Neuronal Survival after Fluid Percussion Traumatic Brain Injury in Rats

Autor: Jack Nguyen, Ken C. Van, Tao Wang, Gregory T. Went, Bruce G. Lyeth, Xian Jian Huang

Publikováno v: Journal of Neurotrauma. 31:370-377

This study evaluated the effects of clinically relevant concentrations of amantadine (AMT) on cognitive outcome and hippocampal cell survival in adult rats after lateral fluid percussion traumatic brain injury (TBI). AMT is an antagonist of the N-met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca30026120145c26e2ab4a40ff16442b
https://doi.org/10.1089/neu.2013.2917

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Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents

Autor: Donald F. Smee, E. Bart Tarbet, Justin G. Julander, Jack Nguyen, Matthew Gross

Publikováno v: Antiviral Research. 96:13-20

Influenza A/Mississippi/03/2001 (H1N1) and A/Hong Kong/2369/2009 (H1N1) viruses containing the neuraminidase gene mutation H275Y (conferring resistance to oseltamivir) were adapted to mice and evaluated for suitability as models for lethal infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e2403847e844f010fa8d957c38d337
https://doi.org/10.1016/j.antiviral.2012.07.002

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In Vitro System for Modeling Influenza A Virus Resistance under Drug Pressure

Autor: Qingmei Weng, Kelly Sheff, David M. Engelthaler, Ashley N. Brown, Elizabeth M. Driebe, Jack Nguyen, George L. Drusano, Paul Keim, James J. McSharry

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:3442-3450

One of the biggest challenges in the effort to treat and contain influenza A virus infections is the emergence of resistance during treatment. It is well documented that resistance to amantadine arises rapidly during the course of treatment due to mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32723a9cec6804275759da35c04f08f7
https://doi.org/10.1128/aac.01385-09

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Rapid quantification of single-nucleotide mutations in mixed influenza A viral populations using allele-specific mixture analysis

Autor: Qingmei Weng, Paul Keim, David M. Engelthaler, Elizabeth M. Driebe, Erin Kelley, Jack Nguyen, James M. Schupp, James J. McSharry, Cindy M. Liu

Publikováno v: Journal of Virological Methods. 163:109-115

Monitoring antiviral resistance in influenza is critical to public health epidemiology and pandemic preparedness activities. Effective monitoring requires methods to detect low-level resistance and to monitor the change in resistance as a function of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3027c5830f4de90799db5957fafbb088
https://doi.org/10.1016/j.jviromet.2009.09.007

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Triple Combination of Oseltamivir, Amantadine, and Ribavirin Displays Synergistic Activity against Multiple Influenza Virus Strains In Vitro

Autor: Gregory T. Went, Justin D. Hoopes, Paul Keim, Jack Nguyen, Minh H. Le, Paul Spence, David M. Engelthaler, Donald F. Smee, Mark N. Prichard, Elizabeth M. Driebe

Publikováno v: Antimicrobial Agents and Chemotherapy. 53:4115-4126

The recurring emergence of influenza virus strains that are resistant to available antiviral medications has become a global health concern, especially in light of the potential for a new influenza virus pandemic. Currently, virtually all circulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106ffbfe61cd96e96f4debb63542e3bd
https://doi.org/10.1128/aac.00476-09

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Modeling amantadine treatment of influenza A virus in vitro

Autor: Jack Nguyen, Catherine A. A. Beauchemin, Ruy M. Ribeiro, Alan S. Perelson, Gregory T. Went, James J. McSharry, George L. Drusano

Publikováno v: Journal of Theoretical Biology. 254:439-451

We analyzed the dynamics of an influenza A/Albany/1/98 (H3N2) viral infection, using a set of mathematical models highlighting the differences between in vivo and in vitro infection. For example, we found that including virion loss due to cell entry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c100a8085fe4fd9b71d597c737efa50
https://doi.org/10.1016/j.jtbi.2008.05.031

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