Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jack Mottahedeh"'
Autor:
Jack Mottahedeh, Michael C. Haffner, Tristan R. Grogan, Takao Hashimoto, Preston D. Crowell, Himisha Beltran, Andrea Sboner, Rohan Bareja, David Esopi, William B. Isaacs, Srinivasan Yegnasubramanian, Matthew B. Rettig, David A. Elashoff, Elizabeth A. Platz, Angelo M. De Marzo, Michael A. Teitell, Andrew S. Goldstein
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Background Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently reported that human prost
Externí odkaz:
https://doaj.org/article/74edf0c78aa84fd28034f0b9a6de4892
Autor:
Matthew Garrett, Jantzen Sperry, Daniel Braas, Weihong Yan, Thuc M. Le, Jack Mottahedeh, Kirsten Ludwig, Ascia Eskin, Yue Qin, Rachelle Levy, Joshua J. Breunig, Frank Pajonk, Thomas G. Graeber, Caius G. Radu, Heather Christofk, Robert M. Prins, Albert Lai, Linda M. Liau, Giovanni Coppola, Harley I. Kornblum
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Background There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted to discern function by using cell lines transduced with exogenous IDH mutant enz
Externí odkaz:
https://doaj.org/article/642fab9d621f45ce80bff09ea33cbe6b
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (58K) - Secondary screen identified 168 GSC -effective compounds with selective inhibition profile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302cea9e2c5e5c3c011305627a125e05
https://doi.org/10.1158/1535-7163.22496700
https://doi.org/10.1158/1535-7163.22496700
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant subpopulation, here termed GBM stem cells, have been identified as primary the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936f862bc40c80e29e9b13e5de1faaae
https://doi.org/10.1158/1535-7163.c.6535371
https://doi.org/10.1158/1535-7163.c.6535371
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (32K) - GSC-enriched GBM samples form tumors after transplantation into immunodeficient mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3408c4be47793686d6760e6055aa7af
https://doi.org/10.1158/1535-7163.22496703
https://doi.org/10.1158/1535-7163.22496703
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (874K) - A - Representative images demonstrating tumor formation success in an animal transplanted with serum (I) and sphere (II) derived GBM146 Ki67 and Human Nuclei (HuNu) immunostaining shows that virtually all transplanted cells died o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00db59fa4f06a29828248aa2d8979c72
https://doi.org/10.1158/1535-7163.22496733
https://doi.org/10.1158/1535-7163.22496733
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (67K) - Effects of OLDA, PALDA and NADA are not mediated via cannabinoid, vanilloid or dopamine receptors A - Exposure of GSC -enriched GBM 157 cells to CB1, CB2, TRPV1 receptor agonists or their combination, does not reproduce the phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ba7e8a7b0999dcba09aa677c2bb339
https://doi.org/10.1158/1535-7163.22496724
https://doi.org/10.1158/1535-7163.22496724
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (61K) - OLDA, Emetine, 5256360 and 5560509 decrease clonal sphere formation in low passage GBM312 Graphs show a concentration-dependent reduction of clonal neurosphere size, neurosphere number as well as total cell mass. Error bars represe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3576740fd851dbfe75037289d8660e
https://doi.org/10.1158/1535-7163.22496718.v1
https://doi.org/10.1158/1535-7163.22496718.v1
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (39K) - Limiting dilution transplantation of GBM157 cells treated with OLDA, 5256360 or 5560509 shows decreased tumor formation frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4016a6edf848075b097a34fa2ed65a1f
https://doi.org/10.1158/1535-7163.22496697
https://doi.org/10.1158/1535-7163.22496697
Autor:
Harley I. Kornblum, Ichiro Nakano, Chiara Sabatti, Jing Huang, Kenneth A. Bradley, Jack Mottahedeh, Michael Masterman-Smith, Eduard H. Panosyan, Jonathan Saxe, Denise Ferrari, David De Vries, Syuzanna Petrosyan, Kuniyasu Saigusa, Robert Damoiseaux, Hideyuki Onodera, Koppany Visnyei
PDF File - (523K) - OLDA, Emetine, 5256360 and 5560509 inhibit proliferation of sphere cultured GBM312 cells, using CFSE (carboxyfluorescein diacetate, succinimidyl ester) cell tracing experiments Proliferative inhibition is graphically represented b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b84d5895217b2478a15990c5fae917
https://doi.org/10.1158/1535-7163.22496715.v1
https://doi.org/10.1158/1535-7163.22496715.v1