Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Jack Michel Renoir"'
Autor:
Coralie Poulard, Juliette Rambaud, Emilie Lavergne, Julien Jacquemetton, Jack-Michel Renoir, Olivier Trédan, Sylvie Chabaud, Isabelle Treilleux, Laura Corbo, Muriel Le Romancer
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126181 (2015)
Protein arginine methylation is a common post translational modification that regulates protein properties. This modification is carried out by a family of nine arginine methyltransferases (PRMTs). Arginine methylation has already been linked to tumo
Externí odkaz:
https://doaj.org/article/8204cb5a444649769729aef18eb85f49
Autor:
Jérémie Gaudichon, Francesco Milano, Julie Cahu, Lætitia DaCosta, Anton C Martens, Jack-Michel Renoir, Brigitte Sola
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107009 (2014)
Tumoral plasma cells has retained stemness features and in particular, a polycomb-silenced gene expression signature. Therefore, epigenetic therapy could be a mean to fight for multiple myeloma (MM), still an incurable pathology. Deazaneplanocin A (D
Externí odkaz:
https://doaj.org/article/62feb4f7c81a457ea40056629f1edefd
Autor:
Muriel D. David, Mélanie Polrot, Josiane Pierre, Jacques Bertoglio, Martine Letourneur, Vladimir Lazar, Serge Roche, Jack-Michel Renoir, Philippe Dessen, Cécile Naudin
Publikováno v:
Molecular Oncology. 8:942-955
Suppressor of cytokine signaling (SOCS) 1 is an inducible negative regulator of cytokine signaling but its role in human cancer is not completely established. Here we report that, while SOCS1 is expressed in normal colonic epithelium and colon adenoc
Autor:
Jack-Michel Renoir
Publikováno v:
Steroids. 77:1249-1261
Estrogen receptors α (ERα) and β (ERβ) are nuclear receptors which transduce estradiol (E2) response in many tissues including the mammary gland and breast cancers (BC). They activate or inhibit specific genes involved in cell cycle progression a
Autor:
Jack-Michel Renoir, Vincent Plassat, Florence Gazeau, Claire Wilhelm, Véronique Marsaud, Christine Ménager, Sylviane Lesieur
Publikováno v:
Advanced Functional Materials. 21:83-92
The selective delivery of the steroid anti-estrogen RU 58668 (RU) to human breast cancer MCF-7 cells by using nanoscaled hybrid liposomes, labelled with rhodamine, coated by poly(ethylene glycol) and entrapping superparamagnetic nanocrystals of maghe
Autor:
Sylviane Lesieur, Giorgia Urbinati, Véronique Marsaud, Jack-Michel Renoir, Elias Fattal, Vincent Plassat
Publikováno v:
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2010, 397 (1-2), pp.184-193. ⟨10.1016/j.ijpharm.2010.06.046⟩
International Journal of Pharmaceutics, Elsevier, 2010, 397 (1-2), pp.184-193. ⟨10.1016/j.ijpharm.2010.06.046⟩
International audience; Histone deacetylase (HDAC) inhibitors (HDACi) of the class I trichostatin A (TSA), CG1521 (CG), and PXD101 (PXD) were incorporated at a high rate (approximately 1mM) in liposomes made of egg phosphatidylcholine/cholesterol/dis
Autor:
Véronique Marsaud, Elias Fattal, Silvia Arpicco, Davide Audisio, Vincent Plassat, Giorgia Urbinati, Jack-Michel Renoir, Brigitte Sola
Publikováno v:
Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2010, ⟨10.1007/s11095-009-0023-z⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2010, ⟨10.1007/s11095-009-0023-z⟩
To determine the better liposomal formulation incorporating the active metabolite of tamoxifen, 4-hydroxy-tamoxifen (4HT) and the biological impact of 4HT-pH-gradient liposomes on response to in vivo treatment. Several pegylated liposomes were formul
Publikováno v:
Journal of Liposome Research. 19:322-331
Rapamycin (Sirolimus) is a macrolide lactone with antifungal, immunosuppressant, and antiproliferative actions. The mechanism of rapamycin action involves the inhibition of mTOR and subsequent cytostasis. Rapamycin also prevents angiogenesis in tumor
Autor:
Véronique Marsaud, Saadia Kerdine-Roemer, Silvia Arpicco, Claudio Surace, Elias Fattal, Amélie Bochot, Ulrich F. Schaefer, Jack-Michel Renoir, Claus-Michael Lehr, Sebastian Taetz
Publikováno v:
Oligonucleotides. 19:103-116
Cationic hyaluronic acid (HA)-modified DOTAP/DOPE liposomes were designed for the targeted delivery of anti-telomerase siRNA to CD44 receptor-expressing lung cancer cells. DOTAP/DOPE liposomes modified with 1%-20% (w/w) HA-DOPE conjugate were obtaine
Autor:
Véronique Marsaud, Jean-Daniel Brion, Samir Messaoudi, Gaëlle Le Bras, Jean-François Peyrat, Mouâd Alami, C Radanyi, Maria-Grazia Catelli, Jack-Michel Renoir
Publikováno v:
Cancer Letters. 274:88-94
We evaluated whether inhibition of heat shock protein 90 (hsp90) function by novobiocin derivatives could induce the degradation of signal transducers that drive cancer cell growth and thereby promote apoptosis. Removal of the noviose moiety in novob