Výsledky vyhledávání - "Jack McGeown"

Supplementary Video 1 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Autor: Travis J. Jerde, Mark R. Kelley, Roberto Pili, Chi Zhang, George E. Sandusky, Hristos Z. Kaimakliotis, Ariel A. Craft, May Elbanna, David W. McIlwain, Jack McGeown, Hanyu Xia, Melissa L. Fishel

Video of caspase 3 activity used to capture images used in quantification of caspase activation, indicating apoptosis induction. Representative video of UC3 cells treated with DMSO control red dye by itself, Duration of the video is the 72 hour durat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b45c9239159680f687995d9f246c7d
https://doi.org/10.1158/1535-7163.22506708.v1

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Supplementary Video 3 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Video of caspase 3 activity used to capture images used in quantification of caspase activation, indicating apoptosis induction. Representative video of UC3 cells treated with APX2009 as red indicator dye generated from Caspase 3. Duration of the vid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee42f76d7fd380b04bb3c78ba0297cd
https://doi.org/10.1158/1535-7163.22506702.v1

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Data from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Bladder cancer is the ninth most common cause of cancer-related deaths worldwide. Although cisplatin is used routinely in treating bladder cancer, refractory disease remains lethal for many patients. The recent addition of immunotherapy has improved

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cbd2cdc8f258ebea1a8a8bc014271822
https://doi.org/10.1158/1535-7163.c.6538470.v1

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Supplementary Figure 2 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Structures and NMR analysis of novel ref-1 inhibitors APX2009 and APX2014. A. APX3330; NMR and HPLC as previously published.15-18 B. APX2009; HPLC: HPLC were performed using an Alltech Alltima column C18 5u, 250 x 5.6 mm, flow 1 mL/min at 40 .C. Elut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c6ea1ee855423e4436642d3421944
https://doi.org/10.1158/1535-7163.22506717

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Supplementary Figure 4 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Confirmation of APE1/Ref-1 and STAT3 expression in 3d and monolayer conditions in RP-B-O1 and RP-B-O2 cells. Basal growth conditions as described in the methods for each cell line were used for monolayer and 3D conditions. No significant differences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b19cfe081f2cbc6cde32773bfe46106
https://doi.org/10.1158/1535-7163.22506711.v1

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Supplementary Figure 3 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Confirmation of cell death induction by caspase activity assay and PARP cleavage. Representative images for caspase activity via red fluorescence [A] for the data calculated and shown in Figure 2, each with matching brightfield images. Representative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ba6586264b8ca68112e7d7f4aa4bb7
https://doi.org/10.1158/1535-7163.22506714

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Supplementary Figure 1 from Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

APE1/Ref-1 localization in human tumors. Additional examples of APE1/Ref-1 immunofluorescence in human bladder cancer specimens at 10X and 40X. Lower power (10X) [A] demonstrates transition from nuclear localized APE1/Ref-1 in the epithelial compartm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4a5e32668c0b58afec062c801bc6e9
https://doi.org/10.1158/1535-7163.22506720

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Antitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer

Autor: Melissa L. Fishel, Jack McGeown, Hristos Z. Kaimakliotis, David W. McIlwain, Roberto Pili, Hanyu Xia, Mark R. Kelley, Chi Zhang, Travis J. Jerde, May Elbanna, George E. Sandusky, Ariel A. Craft

Publikováno v: Mol Cancer Ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37804c077cf2a2aa6ccc89e446be1df
https://doi.org/10.1158/1535-7163.mct-18-1166

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Combined inhibition of Ref-1 and STAT3 leads to synergistic tumour inhibition in multiple cancers using 3D and in vivo tumour co-culture models

Autor: Yan Tong, Michelle Grimard, Jack McGeown, Rachel A. Caston, Roberto Pili, Mark R. Kelley, Colton L. Starcher, Melissa L. Fishel, Fenil Shah, Karen E. Pollok, Teresa A. Zimmers, Joseph E. Rupert, Olivia Babb, Lee Armstrong, Adily N. Elmi, Edward A. Motea, Randall Wireman

Publikováno v: Journal of Cellular and Molecular Medicine

With a plethora of molecularly targeted agents under investigation in cancer, a clear need exists to understand which pathways can be targeted simultaneously with multiple agents to elicit a maximal killing effect on the tumour. Combination therapy p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f621142688f261082a02af021cd8a
https://pubmed.ncbi.nlm.nih.gov/33274592

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