Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jack M. Heath"'
Publikováno v:
Redox Biology, Vol 9, Iss C, Pp 244-253 (2016)
Oxidative stress represents excessive intracellular levels of reactive oxygen species (ROS), which plays a major role in the pathogenesis of cardiovascular disease. Besides having a critical impact on the development and progression of vascular patho
Externí odkaz:
https://doaj.org/article/433f669ce1fe4b368757ad2d93fffa2b
Autor:
Jack M. Heath, Lucky Khambouneheuang, Rachel Simmons, Joan Fernandez Esmerats, Sandeep Kumar, Hanjoong Jo
Publikováno v:
Cardiovascular Engineering and Technology. 9:141-150
PURPOSE: Calcific aortic valve disease (CAVD) is a major cause of morbidity in the aging population, but underlying mechanisms of its progression remain poorly understood. Aortic valve calcification preferentially occurs on the fibrosa, which is subj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcdd247936526afeb72c7cd738755ea
https://doi.org/10.1007/s13239-017-0296-z
https://doi.org/10.1007/s13239-017-0296-z
Autor:
Louis J. Dell'Italia, Wayne E. Bradley, Silvio H. Litovsky, Hui Wu, Yabing Chen, Kaiyu Yuan, Jack M. Heath, Yong Sun, John C. Chatham
Publikováno v:
Circulation Research. 114:1094-1102
Rationale: Vascular calcification is a serious cardiovascular complication that contributes to the increased morbidity and mortality of patients with diabetes mellitus. Hyperglycemia, a hallmark of diabetes mellitus, is associated with increased vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38c13f909af3f6bb534362baf8d1cd1c
https://doi.org/10.1161/circresaha.114.302968
https://doi.org/10.1161/circresaha.114.302968
Autor:
Jack M. Heath, Swetha Rathan, Casey Jane Ankeny, Sandeep Kumar, Ajit P. Yoganathan, Hanjoong Jo, Sivakkumar Arjunon, Zannatul Ferdous, Joan Fernandez Esmerats, Robert M. Nerem
Publikováno v:
Scientific Reports
Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs (miRNA) in the AV are differentially expressed due to disturbed blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e208555ead4fa47e08e5194bafa5fc56
Publikováno v:
Antioxidantsredox signaling. 25(7)
Significance: Currently, calcific aortic valve disease (CAVD) is only treatable through surgical intervention because the specific mechanisms leading to the disease remain unclear. In this review, we explore the forces and structure of the valve, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d28c2ba41150a9a597a4ab12579860
https://pubmed.ncbi.nlm.nih.gov/26651130
https://pubmed.ncbi.nlm.nih.gov/26651130
Autor:
Peter G. Anderson, Xia Mao, Yin Tintut, Deli Wang, Linda L. Demer, Yong Sun, Kaiyu Yuan, Chang Hyun Byon, Jianfeng Chen, Yabing Chen, Jack M. Heath
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 31:1387-1396
Objective— Clinical and experimental studies demonstrate the important roles of vascular smooth muscle cells (VSMC) in the pathogenesis of atherosclerosis. We have previously determined that the osteogenic transcription factor Runx2 is essential fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb00bd20b3da6efc44d8033a5da498a8
https://doi.org/10.1161/atvbaha.110.222547
https://doi.org/10.1161/atvbaha.110.222547
Publikováno v:
Biosystems & Biorobotics ISBN: 9783319218120
Calcific aortic valve disease (CAVD) is a significant cause of mortality among the aging population. Because disease mechanisms are still unclear, the only current treatment option for this disease is aortic valve replacement. In order to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60142148267927617c97501c93df3328
https://doi.org/10.1007/978-3-319-21813-7_11
https://doi.org/10.1007/978-3-319-21813-7_11
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 35(1)
Objective— Vascular calcification is a characteristic feature of atherosclerosis, diabetes mellitus, and end-stage renal disease. We have demonstrated that activation of protein kinase B (AKT) upregulates runt-related transcription factor 2 (Runx2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea43c3fc0301db06fefe52b8a3a5127
https://pubmed.ncbi.nlm.nih.gov/25378413
https://pubmed.ncbi.nlm.nih.gov/25378413
Autor:
Yong Sun, Jack M. Heath, Yabing Chen, Kui Zhang, Xia Mao, Peter G. Anderson, Kaiyu Yuan, Jianfeng Chen, Amjad Javed, Chang Hyun Byon
Publikováno v:
Circulation research. 111(5)
Rationale: Vascular calcification is a hallmark of atherosclerosis, a major cause of morbidity and mortality in the United States. We have previously reported that the osteogenic transcription factor Runx2 is an essential and sufficient regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706dec839a8bfab02d06bea9e6421d61
https://pubmed.ncbi.nlm.nih.gov/22773442
https://pubmed.ncbi.nlm.nih.gov/22773442