Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jack M Moen"'
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 8, Pp n/a-n/a (2023)
Abstract Over the past two decades, synthetic biological systems have revolutionized the study of cellular physiology. The ability to site‐specifically incorporate biologically relevant non‐standard amino acids using orthogonal translation system
Externí odkaz:
https://doaj.org/article/85d65118eae1479585f4602431d54ea4
Autor:
Arash Yavari, Mohamed Bellahcene, Annalisa Bucchi, Syevda Sirenko, Katalin Pinter, Neil Herring, Julia J. Jung, Kirill V. Tarasov, Emily J. Sharpe, Markus Wolfien, Gabor Czibik, Violetta Steeples, Sahar Ghaffari, Chinh Nguyen, Alexander Stockenhuber, Joshua R. St. Clair, Christian Rimmbach, Yosuke Okamoto, Dongmei Yang, Mingyi Wang, Bruce D. Ziman, Jack M. Moen, Daniel R. Riordon, Christopher Ramirez, Manuel Paina, Joonho Lee, Jing Zhang, Ismayil Ahmet, Michael G. Matt, Yelena S. Tarasova, Dilair Baban, Natasha Sahgal, Helen Lockstone, Rathi Puliyadi, Joseph de Bono, Owen M. Siggs, John Gomes, Hannah Muskett, Mahon L. Maguire, Youlia Beglov, Matthew Kelly, Pedro P. N. dos Santos, Nicola J. Bright, Angela Woods, Katja Gehmlich, Henrik Isackson, Gillian Douglas, David J. P. Ferguson, Jürgen E. Schneider, Andrew Tinker, Olaf Wolkenhauer, Keith M. Channon, Richard J. Cornall, Eduardo B. Sternick, David J. Paterson, Charles S. Redwood, David Carling, Catherine Proenza, Robert David, Mirko Baruscotti, Dario DiFrancesco, Edward G. Lakatta, Hugh Watkins, Houman Ashrafian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
AMPK regulates cellular energy balance using its γ subunit as an energy sensor of cellular AMP and ADP to ATP ratios. Here, the authors show that γ2 AMPK activation lowers heart rate by reducing the activity of pacemaker cells, whereas loss of γ2
Externí odkaz:
https://doaj.org/article/93dc1bb6f94248b0bbd5f23512479816
Autor:
Jack M. Moen, Michael G. Matt, Christopher Ramirez, Kirill V. Tarasov, Khalid Chakir, Yelena S. Tarasova, Yevgeniya Lukyanenko, Kenta Tsutsui, Oliver Monfredi, Christopher H. Morrell, Syevda Tagirova, Yael Yaniv, Thanh Huynh, Karel Pacak, Ismayil Ahmet, Edward G. Lakatta
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Heart rate (HR) and HR variability (HRV), predictors of over-all organism health, are widely believed to be driven by autonomic input to the sinoatrial node (SAN), with sympathetic input increasing HR and reducing HRV. However, variability in spontan
Externí odkaz:
https://doaj.org/article/7fc3b43c9f2d41fab516cf4172be9ad0
Autor:
Nolan M. Winicki, Alay P. Nanavati, Christopher H. Morrell, Jack M. Moen, Jessie E. Axsom, Melissa Krawczyk, Natalia N. Petrashevskaya, Max G. Beyman, Christopher Ramirez, Irene Alfaras, Sarah J. Mitchell, Magdalena Juhaszova, Daniel R. Riordon, Mingyi Wang, Jing Zhang, Anthony Cerami, Michael Brines, Steven J. Sollott, Rafael de Cabo, Edward G. Lakatta
Publikováno v:
Frontiers in Cardiovascular Medicine. 9
BackgroundAging is associated with increased levels of reactive oxygen species and inflammation that disrupt proteostasis and mitochondrial function and leads to organism-wide frailty later in life. ARA290 (cibinetide), an 11-aa non-hematopoietic pep
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, Charles Olwal, Weiqing Huang, Thomas Zwaka, John Pham, Molly Lyons, Laura Donohue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López, José María Jimeno Doñaque, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo Garcia-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1fac14fca4140ce96becc2c3766070b
https://doi.org/10.2139/ssrn.4319535
https://doi.org/10.2139/ssrn.4319535
Global landscape of the host response to SARS-CoV-2 variants reveals viral evolutionary trajectories
Autor:
Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Giuditta De Lorenzo, Vanessa Cowton, Abdullah M. Syed, Alison Ciling, Noa Deutsch, Daniel Pirak, Giulia Dowgier, Dejan Mesner, Jane L. Turner, Briana L. McGovern, M. Luis Rodriguez, Rocio Leiva-Rebollo, Alistair S. Dunham, Xiaofang Zhong, Manon Eckhardt, Andrea Fossati, Nicholas Liotta, Thomas Kehrer, Anastasija Cupic, Magda Rutkowska, Nacho Mena, Sadaf Aslam, Alyssa Hoffert, Helene Foussard, John Pham, Molly Lyons, Laura Donahue, Aliesha Griffin, Rebecca Nugent, Kevin Holden, Robert Deans, Pablo Aviles, José Antonio López-Martín, Jose M. Jimeno, Kirsten Obernier, Jacqueline M. Fabius, Margaret Soucheray, Ruth Hüttenhain, Irwin Jungreis, Manolis Kellis, Ignacia Echeverria, Kliment Verba, Paola Bonfanti, Pedro Beltrao, Roded Sharan, Jennifer A. Doudna, Luis Martinez-Sobrido, Arvind Patel, Massimo Palmarini, Lisa Miorin, Kris White, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Lorena Zuliani-Alvarez, Greg J. Towers, Nevan J. Krogan
A series of SARS-CoV-2 variants of concern (VOCs) have evolved in humans during the COVID-19 pandemic—Alpha, Beta, Gamma, Delta, and Omicron. Here, we used global proteomic and genomic analyses during infection to understand the molecular responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8567a33da825246dd5aa0c0571375e
https://doi.org/10.1101/2022.10.19.512927
https://doi.org/10.1101/2022.10.19.512927
Autor:
Jack M. Moen, Christopher H. Morrell, Michael G. Matt, Ismayil Ahmet, Syevda Tagirova, Moran Davoodi, Michael Petr, Shaquille Charles, Rafael de Cabo, Yael Yaniv, Edward G. Lakatta
Publikováno v:
Moen, J M, Morrell, C H, Matt, M G, Ahmet, I, Tagirova, S, Davoodi, M, Petr, M, Charles, S, de Cabo, R, Yaniv, Y & Lakatta, E G 2022, ' Emergence of heartbeat frailty in advanced age I : perspectives from life-long EKG recordings in adult mice ', GeroScience, vol. 44, no. 6, pp. 2801-2830 . https://doi.org/10.1007/s11357-022-00605-4
The combined influences of sinoatrial nodal (SAN) pacemaker cell automaticity and its response to autonomic input determine the heart’s beating interval variability and mean beating rate. To determine the intrinsic SAN and autonomic signatures buri
Autor:
Jack M Moen, Christopher H. Morrell, Ismayil Ahmet, Michael G. Matt, Moran Davoodi, Michael Petr, Shaquille Charles, Raphael deCabo, Yael Yaniv, Edward G Lakatta
SAN failure, aka sick-sinus syndrome, which features sinus bradycardia, SAN impulse pauses, and irregularity of RR interval rhythms are manifestations of SAN cell dysfunction that increases exponentially with advanced age, i.e., SAN frailty. Abnormal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66da87a5ea472132ab3e4f62b18349c
https://doi.org/10.1101/2022.01.12.475659
https://doi.org/10.1101/2022.01.12.475659
Autor:
Carolyn Rutishauser, Jack M. Moen, Jessie Axsom, Alay Nanavati, Edward G. Lakatta, Janet Elise Bonin
Publikováno v:
GeroScience
Mice are among the most widely used translational models of cardiovascular aging and offer a method to quickly assess lifespan changes in a controlled environment. The standard laboratory temperature (20–22 °C), however, imposes a cold stress on m
Publikováno v:
Nature communications. 13(1)
Protein phosphorylation is a ubiquitous post-translational modification used to regulate cellular processes and proteome architecture by modulating protein-protein interactions. The identification of phosphorylation events through proteomic surveilla