Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jack Lohre"'
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited t
Externí odkaz:
https://doaj.org/article/3a2265c1ac814c838bd81c163786a89d
Autor:
Peter S. Lee, Katherine G. MacDonald, Evan Massi, Pamela V. Chew, Christine Bee, Padma Perkins, Bryant Chau, Kent Thudium, Jack Lohre, Pradyot Nandi, Ekaterina G. Deyanova, Ishita Barman, Olafur Gudmundsson, Gavin Dollinger, Tim Sproul, John J. Engelhardt, Pavel Strop, Arvind Rajpal
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), whi
Externí odkaz:
https://doaj.org/article/691eb159503a4399a519acfc7748ae85
Autor:
Ruth Y. Lan, Renu Jain, Jack Lohre, Sandra V. Hatcher, Kai Lu, Sharmila Sambanthamoorthy, Jeff Houser, Logan M. Vlach, Alan J. Korman, Tim W. Sproul, Mark Selby, Priti B. Singh, Nathan O. Siemers, Paul B. Mesko, Bryan R. McDonald, Joseph R. Campbell
Figure S5 shows human splenic and skin expressions of CCR8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea910d6113b477ee28be3a4efdb700d
https://doi.org/10.1158/0008-5472.22430338
https://doi.org/10.1158/0008-5472.22430338
Autor:
Ruth Y. Lan, Renu Jain, Jack Lohre, Sandra V. Hatcher, Kai Lu, Sharmila Sambanthamoorthy, Jeff Houser, Logan M. Vlach, Alan J. Korman, Tim W. Sproul, Mark Selby, Priti B. Singh, Nathan O. Siemers, Paul B. Mesko, Bryan R. McDonald, Joseph R. Campbell
Supplemental materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e367b24ef957365c6ae9ca9650d11e
https://doi.org/10.1158/0008-5472.22430326.v1
https://doi.org/10.1158/0008-5472.22430326.v1
Autor:
Ruth Y. Lan, Renu Jain, Jack Lohre, Sandra V. Hatcher, Kai Lu, Sharmila Sambanthamoorthy, Jeff Houser, Logan M. Vlach, Alan J. Korman, Tim W. Sproul, Mark Selby, Priti B. Singh, Nathan O. Siemers, Paul B. Mesko, Bryan R. McDonald, Joseph R. Campbell
FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens and can repress antitumor immunity through multiple mechanisms. Therefore, targeted depletion of tumor-resident Tregs is warranted to promote effective anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31e7ef976adf7153577afb0d10288c03
https://doi.org/10.1158/0008-5472.c.6513598.v1
https://doi.org/10.1158/0008-5472.c.6513598.v1
Autor:
Paul B Mesko, Sandra V. Hatcher, Priti B. Singh, Renu Jain, Sharmila Sambanthamoorthy, Joseph R Campbell, Tim Sproul, Nathan O. Siemers, Jack Lohre, Alan J. Korman, Logan M Vlach, Ruth Y. Lan, Mark J. Selby, Bryan McDonald, Jeff Houser, Kai Lu
Publikováno v:
Cancer Research. 81:2983-2994
FOXP3+ regulatory T cells (Treg) play a critical role in mediating tolerance to self-antigens and can repress antitumor immunity through multiple mechanisms. Therefore, targeted depletion of tumor-resident Tregs is warranted to promote effective anti
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific reports. 12(1)
T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited to xenogra