Zobrazeno 1 - 10
of 750
pro vyhledávání: '"Jack L. Strominger"'
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens and remain competent to respond to infections both systemically and in placental tissues. Extravillous trophoblasts (EVT) are the most invasive cells of extra-e
Externí odkaz:
https://doaj.org/article/4360c5f15d714c469ad24f29c97e1d3a
Autor:
David S. J. Allan, Ana Sofia Cerdeira, Anuisa Ranjan, Christina L. Kirkham, Oscar A. Aguilar, Miho Tanaka, Richard W. Childs, Cynthia E. Dunbar, Jack L. Strominger, Hernan D. Kopcow, James R. Carlyle
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract For many years, human peripheral blood natural killer (NK) cells have been divided into functionally distinct CD3− CD56bright CD16− and CD3− CD56dim CD16+ subsets. Recently, several groups of innate lymphoid cells (ILC), distinct from
Externí odkaz:
https://doaj.org/article/fdd8503caef444f796bf5bf324863b3b
Autor:
Maria Salvany-Celades, Anita van der Zwan, Marilen Benner, Vita Setrajcic-Dragos, Hannah Ananda Bougleux Gomes, Vidya Iyer, Errol R. Norwitz, Jack L. Strominger, Tamara Tilburgs
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2537-2547.e5 (2019)
Summary: During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in decidual tissues and have been shown to s
Externí odkaz:
https://doaj.org/article/82362ffa0fc845adaf760f5a97290f71
Autor:
Martin E. Hemler, Myles Brown, Jack L. Strominger, Milena M. Andzelm, Alexander R. Kazarov, Chandan Sharma, Pengcheng Zhou, Maria I. Torres-Arzayus, Andrea L. Richardson, Xiuwei H. Yang
Supplementary Table 1 from CD151 Accelerates Breast Cancer by Regulating α6 Integrin Function, Signaling, and Molecular Organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e3333081758c76f65d9819d62c760c
https://doi.org/10.1158/0008-5472.22376499.v1
https://doi.org/10.1158/0008-5472.22376499.v1
Publikováno v:
Immunology
Humanized double transgenic mice express both HLA-DR15 (the MHC gene linked to MS) and TCR.Ob1A12 from a multiple sclerosis patient (that recognizes MBP85-99 presented by HLA-DR15), yet they fail to develop autoimmune encephalomyelitis quickly, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdfa19bdaf2cc1022bb91ce83dbae32
https://doi.org/10.1111/imm.13321
https://doi.org/10.1111/imm.13321
Autor:
Tamara Tilburgs, Ava Meagher, Ângela C. Crespo, Sarika Kshirsagar, Errol R. Norwitz, Jack L. Strominger, Vidya Iyer, Ricardo de Mendonça Vieira
Publikováno v:
J Immunol
Decidual NK cells (dNK) are the main lymphocyte population in early pregnancy decidual mucosa. Although dNK decrease during pregnancy, they remain present in decidual tissues at term. First trimester dNK facilitate trophoblast invasion, provide prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a350655188524194d30836611897ca78
https://doi.org/10.4049/jimmunol.1901435
https://doi.org/10.4049/jimmunol.1901435
Autor:
Sumit Sen Santara, Selma Boulenouar, Judy Lieberman, Jack L. Strominger, Cristian Ovies, Sachin Mulik, Ângela C. Crespo
Publikováno v:
Proc Natl Acad Sci U S A
Zika virus (ZIKV) during pregnancy infects fetal trophoblasts and causes placental damage and birth defects including microcephaly. Little is known about the anti-ZIKV cellular immune response at the maternal–fetal interface. Decidual natural kille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e214c051454a53a5092280e98c74296e
https://doi.org/10.1073/pnas.2115410118
https://doi.org/10.1073/pnas.2115410118
Autor:
Leonardo M. R. Ferreira, Alana Allen, Xiao Han, Songwei Duan, Jennifer H. R. Kenty, Chad A. Cowan, Jack L. Strominger, Yulei Xia, Douglas A. Melton, Paul J. Franco, Torsten B. Meissner, Preston Hedrick, Mengning Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 116:10441-10446
Polymorphic HLAs form the primary immune barrier to cell therapy. In addition, innate immune surveillance impacts cell engraftment, yet a strategy to control both, adaptive and innate immunity, is lacking. Here we employed multiplex genome editing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e71d053d054efa331ce3bb85e6e7500
https://doi.org/10.1073/pnas.1902566116
https://doi.org/10.1073/pnas.1902566116
Autor:
Sarika Kshirsagar, Sai Ma, Qin Li, Jack L. Strominger, Jason D. Buenrostro, Fang Wang, Tamara Tilburgs, Torsten B. Meissner, Ziming Du, Motonari Uesugi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Several techniques have identified ELF3 as particularly important in regulating trophoblast-specific HLA-C expression. This results from a single-nucleotide difference in the promotor of the HLA-C gene at the RFX5 binding site that creat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2058abbf01ec1155e3a4b0152625cd7c
https://pubmed.ncbi.nlm.nih.gov/33622787
https://pubmed.ncbi.nlm.nih.gov/33622787
Autor:
Tamara Tilburgs, Errol R. Norwitz, Jack L. Strominger, Sarika Kshirsagar, Vidya Iyer, Lily Xu, Hannah Ananda Bougleux Gomes, Henrieta Papuchova, Qin Li
Publikováno v:
Proc Natl Acad Sci U S A
During pregnancy, invading HLA-G+ extravillous trophoblasts (EVT) play a key role in placental development, uterine spiral artery remodeling, and prevention of detrimental maternal immune responses to placental and fetal antigens. Failures of these p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d932d288f9d8683a2c08eaa10d3848
https://pubmed.ncbi.nlm.nih.gov/32581122
https://pubmed.ncbi.nlm.nih.gov/32581122