Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Jack L. Feldman"'
Publikováno v:
Frontiers in Neuroanatomy, Vol 14 (2020)
The key driver of breathing rhythm is the preBötzinger Complex (preBötC) whose activity is modulated by various functional inputs, e.g., volitional, physiological, and emotional. While the preBötC is highly interconnected with other regions of the
Externí odkaz:
https://doaj.org/article/c8080c09f4ae474e8f06a8555d42a574
Publikováno v:
Global Advances in Health and Medicine, Vol 10 (2021)
In this viewpoint, we present an argument for transdisciplinary “precision medicine” approaches that combine studies of basic neurobiology of breathing in animal and human models of stress that can help characterize physiological and neural bioma
Externí odkaz:
https://doaj.org/article/bc49b4eb830048bd9fff1ba036648dd3
Autor:
Xiaolu Sun, Carolina Thörn Pérez, Nagaraj Halemani D, Xuesi M Shao, Morgan Greenwood, Sarah Heath, Jack L Feldman, Kaiwen Kam
Publikováno v:
eLife, Vol 8 (2019)
How mammalian neural circuits generate rhythmic activity in motor behaviors, such as breathing, walking, and chewing, remains elusive. For breathing, rhythm generation is localized to a brainstem nucleus, the preBötzinger Complex (preBötC). Rhythmi
Externí odkaz:
https://doaj.org/article/6ab948b88984443998111fe9be1f2afd
Publikováno v:
Annual review of neuroscience, vol 45, iss 1
Annu Rev Neurosci
Annu Rev Neurosci
Breathing is a vital rhythmic motor behavior with a surprisingly broad influence on the brain and body. The apparent simplicity of breathing belies a complex neural control system, the breathing central pattern generator (bCPG), that exhibits diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbda510c9a6c1bb9d0c6d3478f3b034
https://doi.org/10.1146/annurev-neuro-090121-014424
https://doi.org/10.1146/annurev-neuro-090121-014424
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
The preBötzinger Complex (preBötC) encodes inspiratory time as rhythmic bursts of activity underlying each breath. Spike synchronization throughout a sparsely connected preBötC microcircuit initiates bursts that ultimately drive the inspiratory mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48785c3d3699bf6b888b7b711ed9a405
https://pubmed.ncbi.nlm.nih.gov/36400528
https://pubmed.ncbi.nlm.nih.gov/36400528
Autor:
M. Safwan Badr, Danny J. Eckert, Reena Mehra, Rami Khayat, Winfried Randerath, Scott A. Sands, Jennifer L. Martin, Jack L. Feldman, Shahrokh Javaheri, Jeremy E. Orr, Indu Ayappa, Virend K. Somers, Chandra L. Jackson, Matthew T. Naughton
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American journal of respiratory and critical care medicine, vol 203, iss 6
American journal of respiratory and critical care medicine, vol 203, iss 6
Background: Central sleep apnea (CSA) is common among patients with heart failure and has been strongly linked to adverse outcomes. However, progress toward improving outcomes for such patients has been limited. The purpose of this official statement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d722deb23611f4232cb361f847d4b5
https://doi.org/10.1164/rccm.202101-0190st
https://doi.org/10.1164/rccm.202101-0190st
Publikováno v:
eLife, Vol 5 (2016)
Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interaction
Externí odkaz:
https://doaj.org/article/de24105b9e70402cb40de3c8dfab0ecf
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21329ce94d9a6e6614ded14b00fe300a
https://doi.org/10.2139/ssrn.4117921
https://doi.org/10.2139/ssrn.4117921
Publikováno v:
J Physiol
KEY POINTS We transfected preBotC SST+ neurons, which modulate respiratory pattern but are not rhythmogenic, with channelrhodopsin to investigate phase- and state-dependent modulation of breathing pattern in anesthetized and freely behaving mice in n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc4b29092a690143d9e2f17e9030736
https://europepmc.org/articles/PMC9261878/
https://europepmc.org/articles/PMC9261878/
Autor:
Patrice G. Guyenet, Tracy L. Baker, Robert L. Owens, Jack L. Feldman, Brandon Nokes, Jean M. Rawling, Atul Malhotra, Tammie Bishop, Jerome A. Dempsey, Jeremy E. Orr, Marc J. Poulin, Tatum S. Simonson, Emma J. Hodson, Jyoti J. Watters, Magdy Younes, Esteban A. Moya, Robert B. Banzett, Gordon S. Mitchell, Christopher N. Schmickl
Publikováno v:
The Journal of physiology, vol 599, iss 4
The Journal of Physiology
J Physiol
The Journal of Physiology
J Physiol
The clinical presentation of COVID‐19 due to infection with SARS‐CoV‐2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b828140872dc6000c4cd65e55c1eb278
https://escholarship.org/uc/item/5tk5j1s7
https://escholarship.org/uc/item/5tk5j1s7