Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex

Autor: Matthew R. Fleming, Maile R. Brown, Jack Kronengold, Yalan Zhang, David P. Jenkins, Gulia Barcia, Rima Nabbout, Anne E. Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S. Navaratnam, Leonard K. Kaczmarek

Publikováno v: Cell Reports, Vol 16, Iss 9, Pp 2281-2288 (2016)

Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylat

Externí odkaz: https://doaj.org/article/2cfbf9c489e94d12aaac50269099564c

The N-Terminal Domain of Slack Determines the Formation and Trafficking of Slick/Slack Heteromeric Sodium-Activated Potassium Channels

Autor: Yangyang Yan, Leonard K. Kaczmarek, Maile R. Brown, Liqun Ma, Gonzalo Ferreira, Youshan Yang, Jack Kronengold, Lawrence Salkoff, Haijun Chen, Valeswara-Rao Gazula, Fred J. Sigworth, Arin Bhattacharjee

Publikováno v: The Journal of Neuroscience. 29:5654-5665

Potassium channels activated by intracellular Na+ions (KNa) play several distinct roles in regulating the firing patterns of neurons, and, at the single channel level, their properties are quite diverse. Two known genes,SlickandSlack, encodeKNachanne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9ad4b1c78c8367766b1a6330a563ba
https://doi.org/10.1523/jneurosci.5978-08.2009

Human Slack potassium channel mutations increase positive cooperativity between individual channels

Autor: Jenny C. Taylor, Laurence Colleaux, Leonard K. Kaczmarek, Giulia Barcia, Hilary C. Martin, Jack Kronengold, Rima Nabbout, Imran H. Quraishi, Grace Kim, Edward Blair, Olivier Dulac

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2014, 9 (5), pp.1661-1672. ⟨10.1016/j.celrep.2014.11.015⟩
Cell Reports, Vol 9, Iss 5, Pp 1661-1672 (2014)

Summary: Disease-causing mutations in ion channels generally alter intrinsic gating properties such as activation, inactivation, and voltage dependence. We examined nine different mutations of the KCNT1 (Slack) Na+-activated K+ channel that give rise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94327bfc3fcfa25773920cfc1349d1df
https://europepmc.org/articles/PMC4294418/

Single-channel SCAM Identifies Pore-lining Residues in the First Extracellular Loop and First Transmembrane Domains of Cx46 Hemichannels

Autor: E. B. Trexler, Vytas K. Verselis, Thaddeus A. Bargiello, Feliksas F. Bukauskas, Jack Kronengold

Publikováno v: The Journal of General Physiology

Gap junction (GJ) channels provide an important pathway for direct intercellular transmission of signaling molecules. Previously we showed that fixed negative charges in the first extracellular loop domain (E1) strongly influence charge selectivity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cfd293c05076a2100c7cf3a7b8f572
https://doi.org/10.1085/jgp.200308861

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack

Autor: John G. Strumbos, Jack Kronengold, Leonard K. Kaczmarek, Maile R. Brown, Valeswara-Rao Gazula, Fred J. Sigworth, Dhasakumar Navaratnam, Yi Chen

Publikováno v: Nature neuroscience

In humans, absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome (FXS), the most common inherited form of intellectual disability. Here we report through biochemical and electrophysiological stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a0ced84554781f8a276b4fb75d156a
https://doi.org/10.1038/nn.2563