Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jack K Donohue"'
Autor:
Bellal Joseph, Raminder Nirula, Brian J Eastridge, Jason L Sperry, Gary Vercruysse, Francis X Guyette, Joshua B Brown, Richard S Miller, Brian G Harbrecht, Herb A Phelan, Matthew D Neal, Jack K Donohue, Nidhi Iyanna, John M Lorence, Terence O'Keeffe, Jeffrey A Claridge, Elizabeth Gimbel, Brian J Daley
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Background The reporting of adverse events (AEs) is required and well defined in the execution of clinical trials, but is poorly characterized particularly in prehospital trials focusing on traumatic injury. In the setting of prehospital traumatic in
Externí odkaz:
https://doaj.org/article/b85cd3a6c6fb4d58bf1919d3111354b5
Autor:
Bellal Joseph, Raminder Nirula, Brian J Eastridge, Jason L Sperry, Joshua B Brown, Matthew D Neal, Gary A Vercruysse, Jack K Donohue, Nidhi Iyanna, John M Lorence, Frances X Guyette, Terence O'Keeffe
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Background Tranexamic acid (TXA) has been hypothesized to mitigate coagulopathy in patients after traumatic injury. Despite previous prehospital clinical trials demonstrating a TXA survival benefit, none have demonstrated correlated changes in thromb
Externí odkaz:
https://doaj.org/article/57965e24b9a949b5ac468d7df743f619
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Ainara Claveras Cabezudo, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large
Externí odkaz:
https://doaj.org/article/164d0c141a984b619e153ae313a859dd
Autor:
Jack K. Donohue, Jason L. Sperry, Philip C. Spinella, Darrell J. Triulzi, Christine L. Leeper, Mark H. Yazer
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTBackground The introduction of low titer group O whole blood (LTOWB) that contains potentially ABO-incompatible plasma and the increasing use of group A plasma, due to shortages of AB plasma, in trauma patients whose ABO group is unknown coul
Externí odkaz:
https://doaj.org/article/d92c028323ad491e8b8ba4a3ec042216
Autor:
Benedikt Goretzki, Christoph Wiedemann, Brett A. McCray, Stefan L. Schäfer, Jasmin Jansen, Frederike Tebbe, Sarah-Ana Mitrovic, Julia Nöth, Jack K. Donohue, Cy M. Jeffries, Wieland Steinchen, Florian Stengel, Charlotte J. Sumner, Gerhard Hummer, Ute A. Hellmich
Intrinsically disordered regions (IDRs) are essential for membrane receptor regulation but often remain unresolved in structural studies. TRPV4, a member of the TRP vanilloid channel family involved in thermo- and osmosensation, has a large N-termina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f44518da6b4f14f311d51b48232e18bc
https://doi.org/10.1101/2022.12.21.521430
https://doi.org/10.1101/2022.12.21.521430
Autor:
William H. Aisenberg, Brett A. McCray, Jeremy M. Sullivan, Erika Diehl, Lauren R. DeVine, Jonathan Alevy, Anna M. Bagnell, Patrice Carr, Jack K. Donohue, Benedikt Goretzki, Robert N. Cole, Ute A. Hellmich, Charlotte J. Sumner
Publikováno v:
Journal of Biological Chemistry. 298:101826
Ubiquitin (Ub)-mediated regulation of plasmalemmal ion channel activity canonically occurs via stimulation of endocytosis. Whether ubiquitination can modulate channel activity by alternative mechanisms remains unknown. Here, we show that the transien
Autor:
Jack K. Donohue, Danielle S. Gruen, Nidhi Iyanna, John M. Lorence, Joshua B. Brown, Francis X. Guyette, Brian J. Daley, Brian J. Eastridge, Richard S. Miller, Raminder Nirula, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Gary A. Vercruysse, Terence O’Keeffe, Bellal Joseph, Matthew D. Neal, Timothy R. Billiar, Jason L. Sperry
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Injury mechanism is an important consideration when conducting clinical trials in trauma. Mechanisms of injury may be associated with differences in mortality risk and immune response to injury, impacting the potential success of the trial.
Externí odkaz:
https://doaj.org/article/fb736ecef55a4e4d8e607f38370a6f96