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Akademický článek

NODDI in gray matter is a sensitive marker of aging and early AD changes

Autor: Xi Yu, Scott A. Przybelski, Robert I. Reid, Timothy G. Lesnick, Sheelakumari Raghavan, Jonathan Graff‐Radford, Val J. Lowe, Kejal Kantarci, David S. Knopman, Ronald C. Petersen, Clifford R. Jack Jr., Prashanthi Vemuri

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)

Abstract INTRODUCTION Age‐related and Alzheimer's disease (AD) dementia–related neurodegeneration impact brain health. While morphometric measures from T1‐weighted scans are established biomarkers, they may be less sensitive to earlier changes.

Externí odkaz: https://doaj.org/article/68f17f5c04e049068a8e8c8632f60d2c

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Akademický článek

Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies

Autor: Neha Atulkumar Singh, Austin W. Goodrich, Jonathan Graff-Radford, Mary M. Machulda, Irene Sintini, Arenn F. Carlos, Carling G. Robinson, Robert I. Reid, Val J. Lowe, Clifford R. Jack, Jr, Ronald C. Petersen, Bradley F. Boeve, Keith A. Josephs, Kejal Kantarci, Jennifer L. Whitwell

Publikováno v: NeuroImage, Vol 290, Iss , Pp 120564- (2024)

Posterior cortical atrophy (PCA) and dementia with Lewy bodies (DLB) show distinct atrophy and overlapping hypometabolism profiles, but it is unknown how disruptions in structural and functional connectivity compare between these disorders and whethe

Externí odkaz: https://doaj.org/article/c9523c15658b48e5b201ae474cbd48e7

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Akademický článek

Speech-language within and between network disruptions in primary progressive aphasia variants

Autor: Neha Singh-Reilly, Hugo Botha, Joseph R. Duffy, Heather M. Clark, Rene L. Utianski, Mary M. Machulda, Jonathan Graff-Radford, Christopher G. Schwarz, Ronald C. Petersen, Val J. Lowe, Clifford R. Jack, Jr, Keith A. Josephs, Jennifer L. Whitwell

Publikováno v: NeuroImage: Clinical, Vol 43, Iss , Pp 103639- (2024)

Primary progressive aphasia (PPA) variants present with distinct disruptions in speech-language functions with little known about the interplay between affected and spared regions within the speech-language network and their interaction with other fu

Externí odkaz: https://doaj.org/article/67ce0fdfcf9a4894abf06efac9019079

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Akademický článek

Complex relationships of socioeconomic status with vascular and Alzheimer’s pathways on cognition

Autor: Dror Shir, Jonathan Graff-Radford, Angela J. Fought, Timothy G. Lesnick, Scott A. Przybelski, Maria Vassilaki, Val J. Lowe, David S. Knopman, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack, Jr, Michelle M. Mielke, Prashanthi Vemuri

Publikováno v: NeuroImage: Clinical, Vol 43, Iss , Pp 103634- (2024)

Introduction: AD and CVD, which frequently co-occur, are leading causes of age-related cognitive decline. We assessed how demographic factors, socioeconomic status (SES) as indicated by education and occupation, vascular risk factors, and a range of

Externí odkaz: https://doaj.org/article/feaeeef564a042beb90734dee33646ca

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Akademický článek

Performance of the Lumipulse plasma Aβ42/40 and pTau181 immunoassays in the detection of amyloid pathology

Autor: Daniel J. Figdore, Heather J. Wiste, Joshua A. Bornhorst, Randall J. Bateman, Yan Li, Jonathan Graff‐Radford, David S. Knopman, Prashanthi Vemuri, Val J. Lowe, Clifford R. Jack Jr, Ronald C. Petersen, Alicia Algeciras‐Schimnich

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)

Abstract INTRODUCTION This study evaluated the performance of the Lumipulse plasma beta‐amyloid (Aβ) 42/40 and pTau181 compared to other assays to detect an abnormal amyloid‐positron emission tomography (PET). METHODS Plasma samples from cogniti

Externí odkaz: https://doaj.org/article/58bfb3ece9c642f09b11f2a1ba46b37d

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