Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jack J. Hawiger"'
Suppressor of cytokine signaling 3 (SOCS3) regulates the proinflammatory cytokine signaling mediated by the JAK/STAT signaling pathway. SOCS3 is rapidly induced and then targeted to the ubiquitin-proteasome pathway via a mechanism that requires the C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155c12e185be03698398e05a426f89d1
https://europepmc.org/articles/PMC2881796/
https://europepmc.org/articles/PMC2881796/
Autor:
Jack J. Hawiger, James M. Musser
Publikováno v:
Critical Care
Sepsis continues to pose a clear challenge as one of the most difficult and costly problems to treat and prevent. Sepsis is caused by systemic or localized infections that damage the integrity of microcirculation in multiple organs. The challenge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5737e64b4252e615e2ed136f8160673
http://europepmc.org/articles/PMC3388672
http://europepmc.org/articles/PMC3388672
Publikováno v:
Blood. 51:799-812
Human fibrinogen interacts with pathogenic staphylococci, causing their clumping through an unexplained mechanism. We attempted to characterize the interaction between the staphylococcal fibrinogen receptor(s) and the binding region on the fibrinogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c165bacd1f5cae77a368803859a22401
https://doi.org/10.1182/blood.v51.5.799.799
https://doi.org/10.1182/blood.v51.5.799.799
Publikováno v:
Thrombosis and Haemostasis. 43:185-188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0f83f95115bd62e6340c112bbff9e34
https://doi.org/10.1055/s-0038-1650047
https://doi.org/10.1055/s-0038-1650047
Autor:
Jack J. Hawiger, Takayoshi Fujimoto
Publikováno v:
Nature. 297:154-156
Blood platelets seal off leaks in the vessel wall to prevent haemorrhage by a mechanism involving their activation, adhesion to the zone of vessel injury and aggregation1. This physiologically important haemostatic process requires Factor VIII/von Wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c289a52c36874bbb185caef2c409b03
https://doi.org/10.1038/297154a0
https://doi.org/10.1038/297154a0
Publikováno v:
Nature. 283:195-197
Prostacyclin (prostaglandin I2, PGI2), produced by the blood vessel wall is the most potent known inhibitor of platelet aggregation induced by such stimuli as ADP and thrombin. It binds to a specific platelet receptor and activates adenylate cyclase,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7020cbc10e562e487bd5f92549354d69
https://doi.org/10.1038/283195a0
https://doi.org/10.1038/283195a0
Autor:
Charles Cheng, Sylvia Steckley, Alan D. Glick, Sheila Timmons, D. K. Hammond, Roger M. Des Prez, Jack J. Hawiger
Publikováno v:
The Journal of clinical investigation. 64(4)
Bloodstream infections with staphylococci are accompanied by thromboembolic complications. We have studied the mechanism of the interaction of staphylococci with human blood platelets. Staphylococci that possess protein A, a bacterial receptor for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb62734e036f82931d4d9212b8f1ad4
https://pubmed.ncbi.nlm.nih.gov/479376
https://pubmed.ncbi.nlm.nih.gov/479376
Autor:
Sheila Timmons, David Robertson, Jack J. Hawiger, Rose Marie Robertson, GottliebC. Friesinger
Publikováno v:
Lancet (London, England). 2(8199)
Five out of twenty patients with vasotonic angina had frequent spontaneous attacks with dramatic ST-segment alterations. These attacks were consistently associated with an increase in platelet aggregates in coronary-sinus blood but not arterial blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb2159d1832cf2630b1224220b2cf6e5
https://pubmed.ncbi.nlm.nih.gov/6107502
https://pubmed.ncbi.nlm.nih.gov/6107502
Publikováno v:
Thrombosis and Haemostasis Vth Congress.
The ability of human fibrinogen to interact with some staphylococci to cause a non-enzymatic clumping reaction has been used to detect fibrinogen and its derivates in blood and body fluids. We studied localization of the binding site for staphylococc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066d4ac39e5fccb0c0439ac4421f9b44
https://doi.org/10.1055/s-0039-1689107
https://doi.org/10.1055/s-0039-1689107
Autor:
Sheila Timmons, Jack J. Hawiger
Publikováno v:
Thrombosis research. 12(2)
Currently used gel filtration methods were investigated in order to obtain a system which would effectively separate platelets from plasma proteins, such as Factor VIII/von Willebrand factor (FVIIIVWF), in relatively small samples of human blood whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e47035424456e32f0ca139d1526c90
https://pubmed.ncbi.nlm.nih.gov/635845
https://pubmed.ncbi.nlm.nih.gov/635845