Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jack Huet"'
Autor:
Nadia Meddad-Bel Habich, Jean-Edouard Ombetta, Aazdine Lamouri, Françoise Heymans, Léon Assogba, Azali Ahamada-Himidi, Chang-Zhi Dong, Jean-Jacques Godfroid, Darina Aoun, Jack Huet, Latifa Boukli, Carine Mounier
Publikováno v:
European Journal of Medicinal Chemistry. 40:850-861
Starting from 4-tetradecyloxybenzamidine ( PMS815 ), a non-specific inhibitor of GI and GII PLA 2 s, we report in this work the discovery of the specificity through design, synthesis and structure–activity relationships studies of different kinds o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344bd152866c9acc1617d8c4905d47c3
https://doi.org/10.1016/j.ejmech.2005.03.027
https://doi.org/10.1016/j.ejmech.2005.03.027
Autor:
Stéphanie Plocki, Darina Aoun, Azali Ahamada-Himidi, Fernanda Tavarès-Camarinha, Chang-Zhi Dong, France Massicot, Jack Huet, Sylvie Adolphe-Pierre, François Chau, Jean-Jacques Godfroid, Nohad Gresh, Jean Edouard Ombetta, Françoise Heymans
Publikováno v:
European Journal of Organic Chemistry. 2005:2747-2757
3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work, based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2907849bd2cff3ea49fcf945e4a99b0d
https://doi.org/10.1002/ejoc.200400541
https://doi.org/10.1002/ejoc.200400541
Autor:
Jack Huet, Marc Martin, Okkacha Bensaid, Erwan Kan, Dominique Dormont, Nathalie Dereuddre-Bosquet, Catherine Redeuilh, Nawal Serradji, Chang-Zhi Dong, Aazdine Lamouri, Pascal Clayette, Jean-Jacques Godfroid, Françoise Heymans
Publikováno v:
Journal of Medicinal Chemistry. 43:2149-2154
Excessive levels of PAF and cells of macrophage lineage appear to play an important role in neuronal cell injury, inflammatory syndrome, and HIV replication in CNS resulting in AIDS dementia complex (ADC). The beneficial effects of PAF receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcb0491e61c3858ec4aa5f891a0f74f
https://doi.org/10.1021/jm9911276
https://doi.org/10.1021/jm9911276
Publikováno v:
Canadian Journal of Chemistry. 77:2015-2024
X-ray analysis of PMS 952 displays two kinds of very strong hydrogen bonds, an intramolecular one stabilizing the conformer A and an intermolecular one that associates conformers A to form two infinite chains. The 1H NMR study of vicinal coupling con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1366629073ffdd4551c32d27b265129b
https://doi.org/10.1139/v99-191
https://doi.org/10.1139/v99-191
Autor:
Jean-Edouard Ombetta, Françoise Heymans, Chang-Zhi Dong, Jean-Jacques Godfroid, Léon Assogba, Estera Touboul, Catherine Redeuilh, Carine Binisti, Jack Huet, Carine Mounier
Publikováno v:
ChemInform. 33
1-Benzoyl-2-alkyl piperazines are strong inhibitors of Group I and II secreted PLA2s. An improvement of their activity was obtained by replacing the amide function by a sulfamide and by introduction of electrodonor substituents on the para position o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a2236f1aa7156e945647a3cbefc4d3
https://doi.org/10.1002/chin.200212268
https://doi.org/10.1002/chin.200212268
Autor:
Françoise Heymans, Salvatore Cisternino, Nathalie Dereuddre-Bosquet, Catherine Redeuilh, Nawal Serradji, Jack Huet, Dominique Dormont, Marc Martin, Chang-Zhi Dong, Jean-Michel Scherrmann, Christophe Rousselle, Okkacha Bensaid, Aazdine Lamouri, Pascal Clayette
Publikováno v:
Journal of medicinal chemistry. 47(25)
The HIV-1 central nervous system infection leads to the onset of neurological impairments called AIDS dementia complex (ADC). PAF plays an important role in this pathology, as it is an HIV-1-induced neurotoxin produced by infected or activated macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63828f5118ee4634fdf49ccddfcaf194
https://pubmed.ncbi.nlm.nih.gov/15566310
https://pubmed.ncbi.nlm.nih.gov/15566310
Autor:
Chang-Zhi Dong, Azali Ahamada-Himidi, Stéphanie Plocki, Darina Aoun, Mohamed Touaibia, Nadia Meddad-Bel Habich, Jack Huet, Catherine Redeuilh, Jean-Edouard Ombetta, Jean-Jacques Godfroid, France Massicot, Françoise Heymans
Publikováno v:
Bioorganicmedicinal chemistry. 13(6)
We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc2d4dbf8f1c4c30b4b98483d28af17
https://pubmed.ncbi.nlm.nih.gov/15727853
https://pubmed.ncbi.nlm.nih.gov/15727853
Autor:
Léon, Assogba, Azali, Ahamada-Himidi, Nadia Meddad-Bel, Habich, Darina, Aoun, Latifa, Boukli, France, Massicot, Carine M, Mounier, Jack, Huet, Aazdine, Lamouri, Jean-Edouard, Ombetta, Jean-Jacques, Godfroid, Chang-Zhi, Dong, Françoise, Heymans
Publikováno v:
European journal of medicinal chemistry. 40(9)
Starting from 4-tetradecyloxybenzamidine (PMS815), a non-specific inhibitor of GI and GII PLA2s, we report in this work the discovery of the specificity through design, synthesis and structure-activity relationships studies of different kinds of PMS8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1edcdf0284fbf1f3b71ae814047d773b
https://pubmed.ncbi.nlm.nih.gov/16084626
https://pubmed.ncbi.nlm.nih.gov/16084626
Autor:
Chang-Zhi Dong, Jack Huet, Françoise Heymans, Léon Assogba, Catherine Redeuilh, Carine Mounier, Carine Binisti, Estera Touboul, Jean-Edouard Ombetta, Jean-Jacques Godfroid
Publikováno v:
European journal of medicinal chemistry. 36(10)
1-Benzoyl-2-alkyl piperazines are strong inhibitors of Group I and II secreted PLA2s. An improvement of their activity was obtained by replacing the amide function by a sulfamide and by introduction of electrodonor substituents on the para position o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ac7d887e9ad441ea3d58153e717547
https://pubmed.ncbi.nlm.nih.gov/11738488
https://pubmed.ncbi.nlm.nih.gov/11738488
Autor:
Fabrice Tavet, Estera Touboul, Françoise Heymans, Jean-Jacques Godfroid, Catherine Redeuilh, Georges Dive, Tounes Bellahsene, Aazdine Lamouri, Jack Huet
Publikováno v:
Journal of lipid mediators and cell signalling. 15(2)
Extensive analysis of results obtained in earlier publications (Lamouri et al. (1993); Tavet et al. (1996) led us to reexamine our interpretations and conclusions about hydrophobic and electronic distribution effects. In terms of hydrophobicity balan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aea00e0834b4f51799a2d6b939d1751
https://pubmed.ncbi.nlm.nih.gov/9034962
https://pubmed.ncbi.nlm.nih.gov/9034962