Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jack Harrington"'
Autor:
Lucy M Kimbley, Rachel Parker, Jack Harrington, Robert C Walker, Ben Grace, Jonathan J West, Tim J Underwood, Matthew JJ Rose-Zerilli
Publikováno v:
BioTechniques, Vol 72, Iss 3, Pp 104-109 (2022)
Single-nuclei RNA sequencing allows single cell-based analysis in frozen tissue, ameliorating cell recovery biases associated with enzymatic dissociation methods. The authors present two optimized methods for isolating and sequencing nuclei from esop
Externí odkaz:
https://doaj.org/article/381a5d78a1c54facaec793d606d3523f
Autor:
Alexandros Tsoupras, Ronan Lordan, Jack Harrington, Rebecca Pienaar, Karen Devaney, Stephanie Heaney, Anastasios Koidis, Ioannis Zabetakis
Publikováno v:
Foods, Vol 9, Iss 4, p 385 (2020)
Tea provides health benefits, while oxidation is part of tea processing. The effect of oxidation on the antithrombotic properties of tea lipid extracts was evaluated for the first time. Total lipids (TL) extracted from fresh tea leaves and commercial
Externí odkaz:
https://doaj.org/article/642ec4716bdb4bc2bbe499b7b03ebfb3
Autor:
Robert C. Walker, Stella P. Breininger, Benjamin P. Sharpe, Jack Harrington, Ian Reddin, Carmen Tse, Rushda Rajak, Annette Hayden, Saqib Rahman, Ben Grace, Fereshteh Izadi, Jonathan West, Maria Secrier, Zoë S. Walters, Matthew J.J. Rose-Zerilli, Timothy J. Underwood
Background: Esophageal adenocarcinoma (EAC) is usually resistant to cytotoxic therapies and immunotherapies have gained little traction. Cancer-associated fibroblasts (CAF) are a major stromal cell population in the EAC tumor microenvironment associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eab746f0ef5928e1daf180ab878a159
https://doi.org/10.21203/rs.3.rs-2572575/v1
https://doi.org/10.21203/rs.3.rs-2572575/v1
Publikováno v:
British Journal of Surgery. 109
Background Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of the histone lysine methyltransferase Polycomb Repressor Complex 2 (PRC2), mediates gene silencing of target genes epigenetically. It is over-expressed and associated with poor
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1865(5)
Histone modifying enzymes are involved in the posttranslational modification of histones and the epigenetic control of gene expression. They play a critical role in normal development, and there is increasing evidence of their role in developmental d
Autor:
Benjamin P. Sharpe, Annette Hayden, Antigoni Manousopoulou, Andrew Cowie, Robert C. Walker, Jack Harrington, Fereshteh Izadi, Stella P. Breininger, Jane Gibson, Oliver Pickering, Eleanor Jaynes, Ewan Kyle, John H. Saunders, Simon L. Parsons, Alison A. Ritchie, Philip A. Clarke, Pamela Collier, Nigel P. Mongan, David O. Bates, Kiren Yacqub-Usman, Spiros D. Garbis, Zoë Walters, Matthew Rose-Zerilli, Anna M. Grabowska, Timothy J. Underwood
The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a351ee9a2592c4c61da5611e4933256a
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
Autor:
Timothy J. Underwood, Jonathan Butement, Marta E Polak, Maaike S. A. Jongen, Andres F. Vallejo, Bhavwanti Sheth, Simon I. R. Lane, Rachel Parker, Ben D. MacArthur, Rosanna C.G. Smith, Matthew J. J. Rose-Zerilli, Jack Harrington, Patrick S. Stumpf, Luis Blay Esteban, Jonathan West
The future of single cell diversity screens involves ever-larger sample sizes, dictating the need for higher throughput methods with low analytical noise to accurately describe the nature of the cellular system. Current approaches are limited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b978739ab39f9032cfb38584f3333c2
https://doi.org/10.1101/2021.04.08.439026
https://doi.org/10.1101/2021.04.08.439026
Autor:
Lucy Kimbley, Rachel Parker, Jack Harrington, Robert C. Walker, Ben Grace, Jonathan J. West, Tim J. Underwood, Matthew JJ Rose Zerilli
Citric acid-based method of isolating nuclei from frozen oesophageal tissue. Protocol adapted from Tosti et al. [1,2] with additional optimisation for oesophageal tissue. 1. Tosti, L., Hang, Y., Debnath, O., Tiesmeyer, S., Trefzer, T., & Steiger, K.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30fb73df9c12c185e6b132c742def9d7
https://doi.org/10.17504/protocols.io.btm6nk9e
https://doi.org/10.17504/protocols.io.btm6nk9e
Autor:
Timothy J. Underwood, Jack Harrington, M Rose-Zerilli, Robert C. Walker, Fergus Noble, B Grace, Megan Lloyd, James P. Byrne, Jamie J. Kelly
Publikováno v:
British Journal of Surgery. 108
Introduction In oesophageal adenocarcinoma with an apparent pathological complete response (pCR) to neoadjuvant therapy (NAT) there remains debate as to whether oesophagectomy is required. Single Cell RNA sequencing (scRNAseq) enables identification
Publikováno v:
British Journal of Surgery. 108
Introduction Gastric mesenchymal tumours are a rare group of neoplasms, which include gastrointestinal stromal tumours (GISTs) and leiomyomas. To date, there is limited information on the tumour microenvironment (TME) in these neoplasms, despite the