Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jack H. Lai"'
Autor:
James M. Henderson, Michelle S. W. Xiang, Jiali Carrie Huang, Stefanie Wetzel, Linxuan Jiang, Jack H. Lai, Wengen Wu, James G. Kench, William W. Bachovchin, Ben Roediger, Geoffrey W. McCaughan, Hui Emma Zhang, Mark D. Gorrell
Publikováno v:
Cancers, Vol 13, Iss 21, p 5495 (2021)
The mRNA expression of the dipeptidyl peptidase 4 (DPP4) gene family is highly upregulated in human hepatocellular carcinoma (HCC) and is associated with poor survival in HCC patients. Compounds that inhibit the DPP4 enzyme family, such as talabostat
Externí odkaz:
https://doaj.org/article/04651d7d2ee047aa86a1c58c3e6fff83
Autor:
Fiona M. Keane, Tsun-Wen Yao, Stefanie Seelk, Margaret G. Gall, Sumaiya Chowdhury, Sarah E. Poplawski, Jack H. Lai, Youhua Li, Wengen Wu, Penny Farrell, Ana Julia Vieira de Ribeiro, Brenna Osborne, Denise M.T. Yu, Devanshi Seth, Khairunnessa Rahman, Paul Haber, A. Kemal Topaloglu, Chuanmin Wang, Sally Thomson, Annemarie Hennessy, John Prins, Stephen M. Twigg, Susan V. McLennan, Geoffrey W. McCaughan, William W. Bachovchin, Mark D. Gorrell
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 43-54 (2014)
The protease fibroblast activation protein (FAP) is a specific marker of activated mesenchymal cells in tumour stroma and fibrotic liver. A specific, reliable FAP enzyme assay has been lacking. FAP's unique and restricted cleavage of the post proline
Externí odkaz:
https://doaj.org/article/699a5667312a445ea11703a45af02b69
Publikováno v:
ARKIVOC, Vol 2013, Iss 1, Pp 135-153 (2013)
Externí odkaz:
https://doaj.org/article/8c457a4c36c4403299c2792c226d4d49
Autor:
Michelle Sui Wen Xiang, James G. Kench, Hui Emma Zhang, Jiali Carrie Huang, Stefanie Wetzel, Mark D. Gorrell, Geoffrey W. McCaughan, Wengen Wu, Ben Roediger, Linxuan Jiang, William W. Bachovchin, James M. Henderson, Jack H. Lai
Publikováno v:
Cancers, Vol 13, Iss 5495, p 5495 (2021)
Cancers
Volume 13
Issue 21
Cancers
Volume 13
Issue 21
Simple Summary This study reported, for the first time, on the expression and activity of the dipeptidyl peptidase 4 (DPP4) family during the development of hepatocellular carcinoma (HCC). We also demonstrated that the pan-DPP inhibitory compound ARI
Autor:
Wengen Wu, Elodie M. Varin, Andrew L. Coppage, Jacqueline L. Beaudry, Brandon L. Panaro, Kirandeep Kaur, Yuxin Liu, Jack H. Lai, Daniel J. Drucker, William W. Bachovchin
Publikováno v:
Molecular Metabolism. 19:65-74
Objective Fibroblast Activation Protein (FAP), an enzyme structurally related to dipeptidyl peptidase-4 (DPP-4), has garnered interest as a potential metabolic drug target due to its ability to cleave and inactivate FGF-21 as well as other peptide su
Autor:
Fiona McLaughlin, Sarah E. Poplawski, David G. Sanford, Andrew Saunders, Jack H. Lai, Matthew Vincent, William W. Bachovchin, Neil Bell
Publikováno v:
Cancer Research. 82:1815-1815
AVA6000 is a therapeutic product based on proprietary pre|CISION™ technology which incorporates a substrate that is sensitive to cleavage by FAP. The pre|CISION™ substrate can be utilized in a drug conjugate linker or to generate chemotherapy pro
Autor:
Robin M. Hallett, Sarah E. Poplawski, Mark H. Dornan, Shin Hye Ahn, Shuang Pan, Wu Wengen, Liu Yuxin, David G. Sanford, Valerie S. Hergott, Quang-De Nguyen, Anthony P. Belanger, Jack H. Lai, William Bachovchin, Joe A. McCann
Publikováno v:
Cancer Research. 82:3303-3303
Background: Fibroblast Activation Protein-α (FAP) is a transmembrane glycoprotein highly expressed on activated fibroblasts. It is a constitutively active 170 kDa serine protease and a member of the dipeptide peptidase (DPP) family, sharing ~50% hom
Autor:
Sarah E. Poplawski, David G. Sanford, Mitchell S. Wang, Eun Bin Go, Daniel A. Bachovchin, William W. Bachovchin, Yuxin Liu, Darren C. Johnson, Michael O Arciprete, Ramya Sridharan, Ashley J. Chui, Wengen Wu, Marian C. Okondo, Todd R. Golub, Jack H. Lai
Publikováno v:
Nature Chemical Biology. 13:46-53
Val-boroPro (Talabostat, PT-100), a nonselective inhibitor of post-proline cleaving serine proteases, stimulates mammalian immune systems through an unknown mechanism of action. Despite this lack of mechanistic understanding, Val-boroPro has attracte
Autor:
Daniel Yagoub, Gyorgy Hutvagner, Wengen Wu, Diana Hatoum, Angelina J. Lay, Jack H. Lai, Sarah Bajan, Rosetta Martiniello-Wilks, Dominik Kaczorowski, Marc R. Wilkins, Pu Xia, Eileen M. McGowan
Publikováno v:
Molecular Endocrinology. 28:1899-1915
Sphingosine kinase 1 (SK1) is a signaling enzyme that catalyzes the formation of sphingosine-1-phosphate. Overexpression of SK1 is causally associated with breast cancer progression and resistance to therapy. SK1 inhibitors are currently being invest
Autor:
Terry J. Fry, James W. Hodge, Wengen Wu, Renee N. Donahue, Jack H. Lai, Peng Zhao, Kwong-Yok Tsang, Christopher P. Kiritsy, Barry Jones, Yuxin Liu, William W. Bachovchin, Brynn B. Duncan
Publikováno v:
Vaccine. 32:3223-3231
Recent studies have suggested that pan inhibitors of dipeptidyl peptidase-4 activity and/or structure homologs (DASH), including ARI-4175, can mediate tumor regression by immune-mediated mechanisms. This study assessed the potential of combining ARI-