Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Jack H. Kaplan"'
Autor:
Dipankar Ash, Varadarajan Sudhahar, Seock-Won Youn, Mustafa Nazir Okur, Archita Das, John P. O’Bryan, Maggie McMenamin, Yali Hou, Jack H. Kaplan, Tohru Fukai, Masuko Ushio-Fukai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The role of endothelial copper transporter ATP7A in vascular function and angiogenesis remains largely unexplored. Here the authors show that ATP7A promotes VEGFR2 signaling and angiogenesis by limiting autophagy-mediated degradation of VEGFR2, which
Externí odkaz:
https://doaj.org/article/7349411310e2453bb951aceb39ac7122
Publikováno v:
Cells, Vol 11, Iss 18, p 2919 (2022)
Inflammation, oxidative stress, and copper (Cu) play an important role in cardiovascular disease, including atherosclerosis. We previously reported that cytosolic Cu chaperone antioxidant-1 (Atox1) translocates to the nucleus in response to inflammat
Externí odkaz:
https://doaj.org/article/3aeaafad0e3844a6911ff982805b910c
Autor:
Archita Das, Dipankar Ash, Abdelrahman Y. Fouda, Varadarajan Sudhahar, Young-Mee Kim, Yali Hou, Farlyn Z. Hudson, Brian K. Stansfield, Ruth B. Caldwell, Malgorzata McMenamin, Rodney Littlejohn, Huabo Su, Maureen R. Regan, Bradley J. Merrill, Leslie B. Poole, Jack H. Kaplan, Tohru Fukai, Masuko Ushio-Fukai
Publikováno v:
Nature Cell Biology. 24:35-50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a66cbb2e93d1f03c98da39f941c33b8
https://doi.org/10.1038/s41556-021-00822-7
https://doi.org/10.1038/s41556-021-00822-7
Autor:
Archita Das, Dipankar Ash, Tetsuo Horimatsu, Tohru Fukai, Masuko Ushio-Fukai, Bhupesh Singla, Silvia Leanhart, Ha Won Kim, Olga Antipova, Gabor Csanyi, David J. Fulton, Joseph White, Neal L. Weintraub, Varadarajan Sudhahar, Stefan Vogt, Jack H. Kaplan
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Copper (Cu) is essential micronutrient, and its dysregulation is implicated in aortic aneurysm (AA) development. The Cu exporter ATP7A (copper-transporting P-type ATPase/Menkes ATPase) delivers Cu via the Cu chaperone Atox1 (antioxidant 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3203458cc2f43b86790109498730b28
https://doi.org/10.1161/atvbaha.119.313374
https://doi.org/10.1161/atvbaha.119.313374
Autor:
Adriana M Zimnicka, Haiyang Tang, Qiang Guo, Frank K Kuhr, Myung-Jin Oh, Jun Wan, Jiwang Chen, Kimberly A Smith, Dustin R Fraidenburg, Moumita S R Choudhury, Irena Levitan, Roberto F Machado, Jack H Kaplan, Jason X-J Yuan
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90544 (2014)
Pulmonary vascular remodeling and increased arterial wall stiffness are two major causes for the elevated pulmonary vascular resistance and pulmonary arterial pressure in patients and animals with pulmonary hypertension. Cellular copper (Cu) plays an
Externí odkaz:
https://doaj.org/article/13005cca34f249ebac95ee232fff417b
Autor:
Rebecca J Clifford, Jack H Kaplan
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84306 (2013)
Cardiotonic steroids (CTS), specific inhibitors of Na,K-ATPase activity, have been widely used for treating cardiac insufficiency. Recent studies suggest that low levels of endogenous CTS do not inhibit Na,K-ATPase activity but play a role in regulat
Externí odkaz:
https://doaj.org/article/2e3b4151ab424d82a3fd287f253ea39b
Autor:
Mustafa Nazir Okur, Sudhahar Varadarajan, Tohru Fukai, Seock Won Youn, Jack H. Kaplan, Dipankar Ash, Xuexiu Fang, Masuko Ushio-Fukai, Yali Hou, John P O'Brien, Malgorzata McMenamin
Publikováno v:
Circulation. 142
Background: VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. Copper (Cu) is essential micronutrient and has been implicated in angiogenesis. The P-type ATPase transporter ATP7A is key regulator of Cu homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd8a4c5be24f6b2e6d81335757f6748
https://doi.org/10.1161/circ.142.suppl_3.13610
https://doi.org/10.1161/circ.142.suppl_3.13610
Autor:
Jack H. Kaplan
The central importance of the role of the sodium pump in almost all eukaryotic cells is by now well appreciated. In cells of the central nervous system the sodium pump is responsible for maintaining the low intracellular [Na] following the inward Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b3c45b69246a11b83c367d013ce1eb
https://doi.org/10.1201/9781003066118-16
https://doi.org/10.1201/9781003066118-16
Autor:
Archita, Das, Dipankar, Ash, Abdelrahman Y, Fouda, Varadarajan, Sudhahar, Young-Mee, Kim, Yali, Hou, Farlyn Z, Hudson, Brian K, Stansfield, Ruth B, Caldwell, Malgorzata, McMenamin, Rodney, Littlejohn, Huabo, Su, Maureen R, Regan, Bradley J, Merrill, Leslie B, Poole, Jack H, Kaplan, Tohru, Fukai, Masuko, Ushio-Fukai
Publikováno v:
Nature cell biology. 24(1)
Vascular endothelial growth factor receptor type 2 (VEGFR2, also known as KDR and FLK1) signalling in endothelial cells (ECs) is essential for developmental and reparative angiogenesis. Reactive oxygen species and copper (Cu) are also involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd0c1318e87e719fe51e24c7ae2621dc
https://pubmed.ncbi.nlm.nih.gov/35027734
https://pubmed.ncbi.nlm.nih.gov/35027734
Autor:
Yali Hou, John P. O'Bryan, Mustafa Nazir Okur, Masuko Ushio-Fukai, Maggie McMenamin, Archita Das, Tohru Fukai, Varadarajan Sudhahar, Jack H. Kaplan, Seock Won Youn, Dipankar Ash
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its role in VEGFR2 signaling and angiogenesis is entirely unknown. Here, we describe th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d7a647272e83ab3e885ec3b7e5a98
https://pubmed.ncbi.nlm.nih.gov/34035268
https://pubmed.ncbi.nlm.nih.gov/34035268