Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jack F. Kirsch"'
Autor:
Uma Sunderam, Pui-Yan Kwok, Rajgopal Srinivasan, Kunal Kundu, Robert J. Currier, Jack F. Kirsch, Jennifer M. Puck, Aashish N. Adhikari
BackgroundDNA sequencing of archived dried blood spots (DBS) collected by newborn screening programs constitutes a potential health resource to study newborn disorders and understand genotype-phenotype relationships. However, its essential to verify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e34fef0811366f65cd8efc5face7f8e4
https://doi.org/10.1101/2020.05.19.105304
https://doi.org/10.1101/2020.05.19.105304
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002614 (2012)
Transcription factors have two functional constraints on their evolution: (1) their binding sites must have enough information to be distinguishable from all other sequences in the genome, and (2) they must bind these sites with an affinity that appr
Externí odkaz:
https://doaj.org/article/6d7ffe701564450b81f475328a66a884
The fitness landscapes of cis-acting binding sites in different promoter and environmental contexts.
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001042 (2010)
The biophysical nature of the interaction between a transcription factor and its target sequences in vitro is sufficiently well understood to allow for the effects of DNA sequence alterations on affinity to be predicted. But even in relatively simple
Externí odkaz:
https://doaj.org/article/eda31ffde9cb4ee7a9d244bc8a789658
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 85:775-811
The Nudix homology clan encompasses over 80,000 protein domains from all three domains of life, defined by homology to each other. Proteins with a domain from this clan fall into four general functional classes: pyrophosphohydrolases, isopentenyl dip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dbaca84f097d978656f841871eeaba0
https://doi.org/10.1002/prot.25223
https://doi.org/10.1002/prot.25223
Over the past thirty years, site-directed mutagenesis has become established as one of the most powerful techniques to probe enzyme reaction mechanisms1-3. Substitutions of active site residues are most likely to yield significant perturbations in ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836cb3ab04986ca7e2471be5ff1778f1
Autor:
Jack F. Kirsch, Steven E. Brenner, John R. Srouji, Michael I. Jordan, Kathryn E. Muratore, Barbara E. Engelhardt
Publikováno v:
Proteins
The subfamily Iα aminotransferases are typically categorized as having narrow specificity toward carboxylic amino acids (AATases), or broad specificity that includes aromatic amino acid substrates (TATases). Because of their general role in central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020974ce96c191e88e68037479b656c5
https://doi.org/10.1002/prot.24318
https://doi.org/10.1002/prot.24318
Publikováno v:
Proteins
Proteins, vol 84, iss 12
Proteins, vol 84, iss 12
The nearly 50,000 known Nudix proteins have a diverse array of functions, of which the most extensively studied is the catalyzed hydrolysis of aberrant nucleotide triphosphates. The functions of 171 Nudix proteins have been characterized to some degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41de6338be415480523c3d1b0db64bb
https://pubmed.ncbi.nlm.nih.gov/27618147
https://pubmed.ncbi.nlm.nih.gov/27618147
Autor:
Edgar Deu, Jack F. Kirsch
Publikováno v:
Protein Science. 20:1991-2003
The existence of low levels of intersubunit communication in homooligomeric enzymes is often difficult to discover, as the identical active sites cannot be probed individually to dissect their interdependent contributions. The homodimeric paralogs, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b0aa1e26126e8f33cfa369de0c9194
https://doi.org/10.1002/pro.741
https://doi.org/10.1002/pro.741
Autor:
Partho Ghosh, Kimberly A. Reynolds, Case W. McNamara, Tracy M. Handel, Jack F. Kirsch, Melinda S. Hanes, Robert A. Bonomo
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 79:1267-1276
Establishing a quantitative understanding of the determinants of affinity in protein-protein interactions remains challenging. For example, TEM-1/β-lactamase inhibitor protein (BLIP) and SHV-1/BLIP are homologous β-lactamase/β-lactamase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04bb0f5c32d7139dbae3d38e841acc7b
https://doi.org/10.1002/prot.22961
https://doi.org/10.1002/prot.22961
Autor:
John P. Richard, Jack F. Kirsch
Publikováno v:
Biographical Memoirs of Fellows of the Royal Society. 57:179-188
The field of enzymology was profoundly affected by the death of Bill Jencks on 3 January 2007, after a 17-year struggle against Alzheimer’s disease. Jencks was a major innovator, a superb teacher, a devoted husband and father, and a helpful friend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64348fde5b5b51869e4e9766f279df7
https://doi.org/10.1098/rsbm.2011.0019
https://doi.org/10.1098/rsbm.2011.0019