Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Jack E. Dixon"'
Autor:
Hui Zhang, Qinyu Zhu, Jixin Cui, Yuxin Wang, Mark J. Chen, Xing Guo, Vincent S. Tagliabracci, Jack E. Dixon, Junyu Xiao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Fam20 proteins are kinases that phosphorylate secreted proteins and proteoglycans. Here the authors present the crystal structures of the three Fam20 kinases and their complexes and give mechanistic insights into substrate recognition and the functio
Externí odkaz:
https://doaj.org/article/17af4b3603344b87a364eec04b64111a
Autor:
Stuart P. Weisberg, Matthew R. Smith-Raska, Jose M. Esquilin, Ji Zhang, Teresita L. Arenzana, Colleen M. Lau, Michael Churchill, Haiyan Pan, Apostolos Klinakis, Jack E. Dixon, Leonid A. Mirny, Siddhartha Mukherjee, Boris Reizis
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 528-540 (2014)
Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncoge
Externí odkaz:
https://doaj.org/article/3573c6cc24d94edc9d0325459f777a08
Autor:
Sandra E. Wiley, Alexander Y. Andreyev, Ajit S. Divakaruni, Robert Karisch, Guy Perkins, Estelle A. Wall, Peter van der Geer, Yi‐Fan Chen, Ting‐Fen Tsai, Melvin I. Simon, Benjamin G. Neel, Jack E. Dixon, Anne N. Murphy
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 6, Pp 904-918 (2013)
Abstract Miner1 is a redox‐active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1−/− mice disp
Externí odkaz:
https://doaj.org/article/57f2fa5f045044f5a634c7f2154fea62
Autor:
Ameya S Walimbe, Hidehiko Okuma, Soumya Joseph, Tiandi Yang, Takahiro Yonekawa, Jeffrey M Hord, David Venzke, Mary E Anderson, Silvia Torelli, Adnan Manzur, Megan Devereaux, Marco Cuellar, Sally Prouty, Saul Ocampo Landa, Liping Yu, Junyu Xiao, Jack E Dixon, Francesco Muntoni, Kevin P Campbell
Publikováno v:
eLife, Vol 9 (2020)
Matriglycan [-GlcA-β1,3-Xyl-α1,3-]n serves as a scaffold in many tissues for extracellular matrix proteins containing laminin-G domains including laminin, agrin, and perlecan. Like-acetyl-glucosaminyltransferase 1 (LARGE1) synthesizes and extends m
Externí odkaz:
https://doaj.org/article/17d3f0ccf58a40a8a791f30363198f9e
Autor:
Adam J Pollak, Canzhao Liu, Aparna Gudlur, Joshua E Mayfield, Nancy D Dalton, Yusu Gu, Ju Chen, Joan Heller Brown, Patrick G Hogan, Sandra E Wiley, Kirk L Peterson, Jack E Dixon
Publikováno v:
eLife, Vol 7 (2018)
Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved in Ca2+ signaling have been shown to be phosphorylated, the biochemical and physiological ro
Externí odkaz:
https://doaj.org/article/ecc097f1b4894d6997ab24d9a2cc0ed7
Autor:
Joshua E. Mayfield, Jack E. Dixon
Publikováno v:
Current Opinion in Chemical Biology. 74:102279
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bfd31057d84a3a1aa9daa7a7ee02b27
https://doi.org/10.1016/j.cbpa.2023.102279
https://doi.org/10.1016/j.cbpa.2023.102279
Autor:
Jixin Cui, Qinyu Zhu, Hui Zhang, Michael A Cianfrocco, Andres E Leschziner, Jack E Dixon, Junyu Xiao
Publikováno v:
eLife, Vol 6 (2017)
Mutations in FAM20A cause tooth enamel defects known as Amelogenesis Imperfecta (AI) and renal calcification. We previously showed that Fam20A is a secretory pathway pseudokinase and allosterically activates the physiological casein kinase Fam20C to
Externí odkaz:
https://doaj.org/article/133ae3712ccc43c19c8673e81b7a55e5
Autor:
Angus W. Jackson, Rita Moreno, Albena T. Dinkova-Kostova, Sourav Banerjee, Jean A. Quinn, Jack E. Dixon, Joanne Edwards, Gregg Baillie, Laureano de la Vega
Publikováno v:
Cell Death and Differentiation
To survive proteotoxic stress, cancer cells activate the proteotoxic-stress response pathway, which is controlled by the transcription factor heat shock factor 1 (HSF1). This pathway supports cancer initiation, cancer progression and chemoresistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce0d718f23811e300b07b9467c9f015
http://europepmc.org/articles/PMC8166837
http://europepmc.org/articles/PMC8166837
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584561fd099f31e7b31b78c581e05430
https://doi.org/10.1096/fasebj.2022.36.s1.r3785
https://doi.org/10.1096/fasebj.2022.36.s1.r3785
Autor:
Qinyu Zhu, David Venzke, Ameya S Walimbe, Mary E Anderson, Qiuyu Fu, Lisa N Kinch, Wei Wang, Xing Chen, Nick V Grishin, Niu Huang, Liping Yu, Jack E Dixon, Kevin P Campbell, Junyu Xiao
Publikováno v:
eLife, Vol 5 (2016)
The ‘pseudokinase’ SgK196 is a protein O-mannose kinase (POMK) that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan on α-dystroglycan. However, the catalytic mechanism underlying this activity remain
Externí odkaz:
https://doaj.org/article/eec560f670404fffbe2ea90fd70ef501