Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jack E. Bowyer"'
Publikováno v:
Engineering Biology (2020)
Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the increased stabi
Externí odkaz:
https://doaj.org/article/53138d4c7d29466fb5d54aaab9de8cc7
Autor:
Jack E. Bowyer, Emmanuel LC. de los Santos, Kathryn M. Styles, Alex Fullwood, Christophe Corre, Declan G. Bates
Publikováno v:
Journal of Biological Engineering, Vol 11, Iss 1, Pp 1-12 (2017)
Abstract Background The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosyntheti
Externí odkaz:
https://doaj.org/article/bb9b181c3e724d16b49de77abbef680d
Publikováno v:
Engineering Biology (2017)
Site-specific recombinases (SSRs) mediate efficient manipulation of DNA sequences in vitro and in vivo. In particular, serine integrases have been identified as highly effective tools for facilitating DNA inversion, enabling the design of genetic swi
Externí odkaz:
https://doaj.org/article/6bb730b46c7c424b9ae0b805d84e9b8e
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1007849 (2020)
PLoS Computational Biology
PLoS Computational Biology
Boolean logic and arithmetic through DNA excision (BLADE) is a recently developed platform for implementing inducible and logical control over gene expression in mammalian cells, which has the potential to revolutionise cell engineering for therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c901a9eba77274dce6c060146792ec21
https://doaj.org/article/171f52aab3d143d892a3a149121a42d6
https://doaj.org/article/171f52aab3d143d892a3a149121a42d6
Autor:
Kathryn M Styles, Alex Fullwood, Declan G. Bates, Christophe Corre, Jack E. Bowyer, Emmanuel L. C. de los Santos
Publikováno v:
Journal of Biological Engineering, Vol 11, Iss 1, Pp 1-12 (2017)
Background The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d365ec8dc43afbbca60014609c000c13
https://doi.org/10.1186/s13036-017-0071-6
https://doi.org/10.1186/s13036-017-0071-6
Publikováno v:
Engineering Biology (2017)
Site-specific recombinases (SSRs) mediate efficient manipulation of DNA sequences in vitro and in vivo. In particular, serine integrases have been identified as highly effective tools for facilitating DNA inversion, enabling the design of genetic swi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d19040183766d2348f4ad6daafa5d7
https://digital-library.theiet.org/content/journals/10.1049/enb.2017.0006
https://digital-library.theiet.org/content/journals/10.1049/enb.2017.0006
Publikováno v:
BioCAS
DNA recombination provides an ideal mechanism for constructing stable and reversible synthetic biological switches. Recent advances in recombinase-based circuitry that account for more than one protein input have been shown to enable the construction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0352ad195784bc6f978cde46014e6feb
https://doi.org/10.1109/biocas.2016.7833832
https://doi.org/10.1109/biocas.2016.7833832
Autor:
Declan G. Bates, Wilson W. Wong, Jack E. Bowyer, Jia Zhao, Pakpoom Subsoontorn, Susan J. Rosser
Many of the most important applications predicted to arise from Synthetic Biology will require engineered cellular memory with the capability to store data in a rewritable and reversible manner upon induction by transient stimuli. DNA recombination p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c1e16ccf01adeb11ffe5386896ad08
http://wrap.warwick.ac.uk/81308/7/WRAP_07478074_.pdf
http://wrap.warwick.ac.uk/81308/7/WRAP_07478074_.pdf
Publikováno v:
EMBC
Engineering cellular memory is a key area of research in which Synthetic Biology has already begun to make significant impacts. Recent work elucidating transcriptional memory devices has paved the way for the creation of bistable genetic switches bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10fd0716545a0686f3a0bb832ec1a23
https://doi.org/10.1109/embc.2015.7318519
https://doi.org/10.1109/embc.2015.7318519