Zobrazeno 1 - 10
of 778
pro vyhledávání: '"Jack E. Baldwin"'
Autor:
Adrian W. Markwell-Heys, Michelle C. Cruickshank, Robert M. Adlington, K. Kuan, Jack E. Baldwin, Denise P. Tran, Jonathan H. George
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2449-2465
The marine sponge Aka coralliphaga is a rich source of biologically active and structurally interesting meroterpenoids. Inspired by these natural products, we have used biosynthetic speculation to devise biomimetic syntheses of siphonodictyal B, liph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ee09da0c39ca2d4f2681d2ca8ab010
https://doi.org/10.1016/j.bmc.2019.02.038
https://doi.org/10.1016/j.bmc.2019.02.038
Publikováno v:
Synlett. 29(08)
A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans-decalin ring of the natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4318e2c2e2d5115d5683b1cbe6f629e2
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
FEBS Letters. 587:2705-2709
Isopenicillin N synthase (IPNS) is a non-heme iron oxidase central to the biosynthesis of β-lactam antibiotics. IPNS converts the tripeptide δ-(l-α-aminoadipoyl)-l-cysteinyl-d-valine (ACV) to isopenicillin N while reducing molecular oxygen to wate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf185c82ec3ae504e15d572d47be7bf
https://doi.org/10.1016/j.febslet.2013.07.016
https://doi.org/10.1016/j.febslet.2013.07.016
Autor:
Andy Lawrence, Jessica A. Kershaw, Jack E. Baldwin, Amber L. Thompson, Victor Lee, Robert M. Adlington
The biosynthesis of the meroterpenoid guajadial was previously hypothesized to occur via a hetero-Diels-Alder reaction between caryophyllene and an o-quinone methide. This hypothesis has been verified via the biomimetic synthesis of guajadial and psi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2a8efbd609545563d840f65110ea35
https://ora.ox.ac.uk/objects/uuid:e28e0313-e6d1-483b-9547-d673ea22addc
https://ora.ox.ac.uk/objects/uuid:e28e0313-e6d1-483b-9547-d673ea22addc
α-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using the Ruppert Reagent (TMS-CF 3 ) and shown to be inhibitors of metallo-β-lactamases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27090b4c6262da94efa82238abacde2b
https://ora.ox.ac.uk/objects/uuid:b20952f2-511c-4030-b416-f10fe2ef6d8a
https://ora.ox.ac.uk/objects/uuid:b20952f2-511c-4030-b416-f10fe2ef6d8a
Autor:
Robert Cassels, Jack E. Baldwin, Christopher J. Schofield, Timothy J. Sewell, Matthew D. Lloyd, Robert M. Adlington, Justin S. Bryans, Keith H. Baggaley
Incubation of the γ-lactam analogue of proclavaminic acid, (±)-threo-5-amino-3-hydroxy-2-(1′-aza-2′-oxocyclopentyl)-pentanoic acid, led to production of two bicyclic γ-lactam products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa46150eee1df003045013821443d025
https://doi.org/10.1016/s0040-4020(97)00399-2
https://doi.org/10.1016/s0040-4020(97)00399-2
Nucleophilic ring opening of optically active N-sulphonyl aziridine-2-carboxylate esters with organometallic reagents has been investigated as a method of preparation of optically active amino acids. © 1993.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d668052f0ed9edd9e36f65e109bcd85c
https://doi.org/10.1016/s0040-4020(01)87968-0
https://doi.org/10.1016/s0040-4020(01)87968-0
A new synthesis of (-)-kainic acid is described based on a cobalt mediated cyclisation reaction of an appropriately modified serine precursor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ef08a82a583b4387da65e59c73af54
https://doi.org/10.1016/s0040-4020(01)87906-0
https://doi.org/10.1016/s0040-4020(01)87906-0
The 1,3,5-trisubstituted aryl diazirine(2) has been synthesised as a photoaffinity probe and has been elaborated to a reagent suitable for application to studies of penicillin and cephalosporin biosynthetic enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b44e0939c79e462e4eb1a5d44ab490
https://doi.org/10.1016/s0040-4020(01)80991-1
https://doi.org/10.1016/s0040-4020(01)80991-1
Autor:
Robert A. Field, Niamh M. O'callaghan, Juliette W. Bird, Jack E. Baldwin, Robert M. Adlington, Christopher J. Schofield
Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8734de98999a44421d14ef090c2e05
https://ora.ox.ac.uk/objects/uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6
https://ora.ox.ac.uk/objects/uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6