Výsledky vyhledávání - "Jack DeZwaan"

Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase

Autor: Jack DeZwaan, Brian J. Stockman, Dennis E. Epps, Ronald W. Sarver, Eric T. Baldwin, Joseph M. Rogers, Melissa S. Harris

Publikováno v: Analytical Biochemistry. 309:186-195

Several small molecules identified by high-throughput screening (HTS) were evaluated for their ability to bind to a nonstructural protein 3 (NS3) helicase from hepatitis C virus (HCV). Equilibrium dissociation constants (K(d)'s) of the compounds for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553d8d60df003079decfb3093de0851b
https://doi.org/10.1016/s0003-2697(02)00301-9

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Micellar electrokinetic chromatography as a generalized alternative to high-performance liquid chromatography for purity determination of a class of investigational antibacterial drugs

Autor: Jackson P Scholl, Jack DeZwaan

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 695:147-156

Micellar electrokinetic chromatography (MEKC) was successfully used to provide purity data for a number of oxazolidinone antibacterials. A run buffer of 100 mM SDS and 40 mM HEPES (pH 7.5, NaOH) separated fifteen different materials of neutral and ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae372e5794587f849a362b668cc2ee48
https://doi.org/10.1016/s0378-4347(97)00043-1

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Thermodynamic and circular dichroism studies differentiate inhibitor interactions with the stromelysin S(1)-S(3) and S(')(1)-S(')(3) subsites

Autor: Jack DeZwaan, Vincent P. Marshall, Brian J. Stockman, Ronald W. Sarver, R. A. Poorman, G. L. Petzold, Peng Yuan

Publikováno v: Biochimica et biophysica acta. 1434(2)

Interactions of stromelysin with a series of inhibitors representative of three chemical templates with distinct binding modes were examined. Unfolding temperatures for inhibitor complexes were 10 degrees C to 15 degrees C greater than for apo strome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e998fa808f993e50864cc18685528
https://pubmed.ncbi.nlm.nih.gov/10525149

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Raman studies of rotational and vibrational relaxation in liquid fluoroform

Autor: Charles S. Johnson, Jack DeZwaan, Doren W. Hess

Publikováno v: The Journal of Chemical Physics. 63:422-426

The rotational correlation functions and correlation times have been determined for liquid fluoroform from 135 to 296 °K by using depolarized Raman light scattering. Both the ν1(A1) hydrogen stretching mode and the ν3(A1) deformation mode were ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf636001a56170d693b2217795c9f193
https://doi.org/10.1063/1.431121

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