Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jack D. Kelly"'
Publikováno v:
Toxicology and Applied Pharmacology. 165:45-52
Poultry are the most susceptible food animal species to the toxic effects of the mycotoxin aflatoxin B(1) (AFB(1)). Feed contaminated with even small amounts of AFB(1) results in significant adverse health effects in poultry. The purpose of this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383cf7d7062a9b76036e097d7d251179
https://doi.org/10.1006/taap.2000.8926
https://doi.org/10.1006/taap.2000.8926
Autor:
Philip A. Burns, Fa Xian Chen, Gina B. Scott, Prasad Dande, Alberto Inga, Paola Monti, Angelo Abbondandolo, Jack D. Kelly, Gilberto Fronza, Barry Gold, Dharini Shah, Anna Aprile
Publikováno v:
Journal of Biological Chemistry. 274:18327-18334
Me-lex, a methyl sulfonate ester appended to a neutral N-methylpyrrolecarboxamide-based dipeptide, was synthesized to preferentially generate N3-methyladenine (3-MeA) adducts which are expected to be cytotoxic rather than mutagenic DNA lesions. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76039bbbf9b38c0f8e7fd73ad0361fd3
https://doi.org/10.1074/jbc.274.26.18327
https://doi.org/10.1074/jbc.274.26.18327
Autor:
Jack D. Kelly
Publikováno v:
Journal of Allergy and Clinical Immunology. 137:AB24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8405a34079cf18d7a24cad9102c992
https://doi.org/10.1016/j.jaci.2015.12.078
https://doi.org/10.1016/j.jaci.2015.12.078
Autor:
David E. Williams, N. Takahashi, Jerry D. Hendricks, Ashok P. Reddy, Mike Dutchuk, Jack D. Kelly
Publikováno v:
Cancer Letters. 74:111-117
Bioactivation in vivo of pure (+) 7S- trans -7,8-dihydrobenzo[ a ]pyrene-7,8-diol ((+) BP-7,8-DHD) was investigated in rainbow trout. Embryos, microinjected with 0.01–1.0 μg of [ 3 H]-(−)-7S- trans -7,8-dihydrobenzo[ a ]-pyrene-7,8-diol-anti-9,1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f528d7566bf1790c6b679e8fa326e3a0
https://doi.org/10.1016/0304-3835(93)90052-b
https://doi.org/10.1016/0304-3835(93)90052-b
Publikováno v:
Cancer Letters. 68:225-229
The hepatocarcinogenic potency of pure and racemic trans-7,8-dihydrobenzo[a]pyrene-7,8-diol was investigated in embryos and sac-fry rainbow trout. Embryos microinjected with (+/-)-trans-7,8-dihydrobenzo[a]pyrene-7,8-diol ((+/-) BP-7,8-DHD) developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d2149c7b7431d2aeee244f8997fe59
https://doi.org/10.1016/0304-3835(93)90150-8
https://doi.org/10.1016/0304-3835(93)90150-8
Publikováno v:
Carcinogenesis. 13:1639-1642
The tumor-enhancing effect of hydrogen peroxide (H2O2) in N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-initiated rainbow trout hepatocarcinogenesis was investigated and correlated with the levels of the mutagenic DNA adduct 8-hydroxy-2'-deoxyguanosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c055ca4da578f03001b845e031986c6
https://doi.org/10.1093/carcin/13.9.1639
https://doi.org/10.1093/carcin/13.9.1639
Publikováno v:
International archives of allergy and immunology. 121(1)
Background: Sunflower seed can cause severe anaphylactic reactions in some susceptible individuals. It is conceivable that the 2S sunflower seed protein is an allergen based on its high degree of homology (34%) with the allergenic mature 2S albumin p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d3d977eab781e5016eb756699c98a5
https://pubmed.ncbi.nlm.nih.gov/10686505
https://pubmed.ncbi.nlm.nih.gov/10686505
Publikováno v:
Chemical research in toxicology. 11(12)
The sequence-specific alkylation of DNA by N-methyl-N-nitrosourea (MNU) has been demonstrated for the minor groove N3-methyladenine (N3-MeAde) adduct using neutral thermal hydrolysis and polyacrylamide sequencing gels. The ratio of relative yields of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc851588f91a1336985025dd8a238406
https://pubmed.ncbi.nlm.nih.gov/9860491
https://pubmed.ncbi.nlm.nih.gov/9860491
Publikováno v:
Toxicology and applied pharmacology. 144(1)
Inhalation exposure to the carcinogen aflatoxin B1 (AFB1) in certain occupations is considerable. Because circumstantial epidemiological evidence suggests that AFB1 inhalation may cause primary lung cancer, we investigated AFB1 activation by human lu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9353d320b44a2d1926ff999cb3a073ec
https://pubmed.ncbi.nlm.nih.gov/9169073
https://pubmed.ncbi.nlm.nih.gov/9169073
Publikováno v:
Toxicology and applied pharmacology. 116(1)
Feeding rainbow trout for 16 weeks a diet in which the levels of vitamin E were reduced 70-fold resulted in marked depletion (18-fold) of vitamin E levels in liver microsomes from these fish. The susceptibility of hepatic microsomes to lipid peroxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf1200319bdedabe7e91c10b0aabd71
https://pubmed.ncbi.nlm.nih.gov/1529456
https://pubmed.ncbi.nlm.nih.gov/1529456