Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jack D. Godfrey"'
Autor:
Ania Wilczynska, Sarah L. Gillen, Tobias Schmidt, Hedda A. Meijer, Rebekah Jukes-Jones, Claudia Langlais, Kari Kopra, Wei-Ting Lu, Jack D. Godfrey, Benjamin R. Hawley, Kelly Hodge, Sara Zanivan, Kelvin Cain, John Le Quesne, Martin Bushell
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Abstract Background Regulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not full
Externí odkaz:
https://doaj.org/article/7d0c484dc2a4472ab9ac49baaa014cd9
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9549 (2022)
The HER2/neu signaling pathway is one of the most frequently mutated in human cancer. Although therapeutics targeting this pathway have good efficacy, cancer cells frequently develop resistance. The HER2 gene encodes the full-length HER2 protein, as
Externí odkaz:
https://doaj.org/article/ba29ab2fb76f46398b7c83b58b5a4dde
Autor:
Claudia Langlais, Benjamin R. Hawley, Sara Zanivan, Sarah L. Gillen, Martin Bushell, Tobias Schmidt, Jack D. Godfrey, Kelvin Cain, John Le Quesne, Wei-Ting Lu, Hedda A. Meijer, Kari Kopra, Ania Wilczynska, Kelly Hodge, Rebekah Jukes-Jones
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)
Genome Biology
Genome Biology
BackgroundRegulation of the mRNA life cycle is central to gene expression control and determination of cell fate. miRNAs represent a critical mRNA regulatory mechanism, but despite decades of research, their mode of action is still not fully understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::444add359bf08aaa4839f1802dab73fb
https://eprints.gla.ac.uk/199869/1/199869.pdf
https://eprints.gla.ac.uk/199869/1/199869.pdf
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 6, Pp 1-14 (2018)
Cell Death and Disease, Vol 9, Iss 6, Pp 1-14 (2018)
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease with poor prognostic implications. This is partly due to a large proportion of PDACs carrying mutations in TP53, which impart gain-of-function characteristics that promote met
Autor:
A. V. Antonov, C. Paicu, Tamas Dalmay, Anna Wilczynska, Jack D. Godfrey, Adam E. Hall, Wei-Ting Lu, Martin Bushell, Simon Moxon, P. A. Muller
Publikováno v:
Hall, A E, Lu, W T, Godfrey, J D, Antonov, A V, Paicu, C, Moxon, S, Dalmay, T, Wilczynska, A, Muller, P A J & Bushell, M 2016, ' The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration ', Cell Death and Disease, vol. 7, e2184 . https://doi.org/10.1038/cddis.2016.91
Cell Death & Disease
Cell Death & Disease
The integrity of the genome is maintained by a host of surveillance and repair mechanisms that are pivotal for cellular function. The tumour suppressor protein p53 is a major component of the DNA damage response pathway and plays a vital role in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eb40ac8c76d992f8cd4c4384e2fec8
https://eprints.gla.ac.uk/178427/1/178427.pdf
https://eprints.gla.ac.uk/178427/1/178427.pdf
Autor:
R. V. Spriggs, S. W. Robinson, Anna Wilczynska, Anne E. Willis, Martin Bushell, Wei-Ting Lu, Yi Wen Kong, Jack D. Godfrey, Hedda A. Meijer
Publikováno v:
Science (New York, N.Y.). 340(6128)
MicroRNAs (miRNAs) control gene expression through both translational repression and degradation of target messenger RNAs (mRNAs). However, the interplay between these processes and the precise molecular mechanisms involved remain unclear. Here, we s