Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Jack D Griffith"'
Publikováno v:
eLife, Vol 10 (2021)
R-loops are a major source of genome instability associated with transcription-induced replication stress. However, how R-loops inherently impact replication fork progression is not understood. Here, we characterize R-loop-replisome collisions using
Externí odkaz:
https://doaj.org/article/f2ac08b1715a4e3499379326792c3c8d
Autor:
Ryan P McNamara, Pauline E Chugh, Aubrey Bailey, Lindsey M Costantini, Zhe Ma, Rachele Bigi, Avery Cheves, Anthony B Eason, Justin T Landis, Kurtis M Host, Jie Xiong, Jack D Griffith, Blossom Damania, Dirk P Dittmer
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007536 (2019)
Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this
Externí odkaz:
https://doaj.org/article/6d9c7b8abac542b6a50b2f47b4f19c4a
Autor:
Allaura S. Cone, Yijun Zhou, Ryan P. McNamara, Anthony. B. Eason, Gabriel F. Arias, Justin T. Landis, Kyle W. Shifflett, Meredith G. Chambers, Runjie Yuan, Smaranda Willcox, Jack D. Griffith, Dirk P. Dittmer
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the biggest public health crises in recent history. Many expect future coronavirus introductions into the human population. Hence, it is essential to understand
Externí odkaz:
https://doaj.org/article/7d31d2f9aa0f4ea7b7d5d5a76ddb2989
Autor:
Regina Sepsiova, Ivona Necasova, Smaranda Willcox, Katarina Prochazkova, Peter Gorilak, Jozef Nosek, Ctirad Hofr, Jack D Griffith, Lubomir Tomaska
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0154225 (2016)
Telomeres of nuclear chromosomes are usually composed of an array of tandemly repeated sequences that are recognized by specific Myb domain containing DNA-binding proteins (telomere-binding proteins, TBPs). Whereas in many eukaryotes the length and s
Externí odkaz:
https://doaj.org/article/2d7e8220c00a478aaa9cb623d06ab857
Autor:
Samantha C Lewis, Priit Joers, Smaranda Willcox, Jack D Griffith, Howard T Jacobs, Bradley C Hyman
Publikováno v:
PLoS Genetics, Vol 11, Iss 2, p e1004985 (2015)
Mitochondrial DNA (mtDNA) encodes respiratory complex subunits essential to almost all eukaryotes; hence respiratory competence requires faithful duplication of this molecule. However, the mechanism(s) of its synthesis remain hotly debated. Here we h
Externí odkaz:
https://doaj.org/article/8a7d960f1ab74accb31fa35fa99f02fc
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83582 (2014)
Although Blm and Top3α are known to form a minimal dissolvasome that can uniquely undo a double Holliday junction structure, the details of the mechanism remain unknown. It was originally suggested that Blm acts first to create a hemicatenane struct
Externí odkaz:
https://doaj.org/article/7b60ccbe58064a0094fda3a138ce7d6b
Autor:
Arnab Roy Chowdhury, Rahul Bakshi, Jianyang Wang, Gokben Yildirir, Beiyu Liu, Valeria Pappas-Brown, Gökhan Tolun, Jack D Griffith, Theresa A Shapiro, Robert E Jensen, Paul T Englund
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001226 (2010)
Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named
Externí odkaz:
https://doaj.org/article/fb8e2012b7964a0091c8eb39ae88ecf7
Publikováno v:
bioRxiv
Molecular interactions between viral DNA and viral-encoded protein are a prerequisite for successful herpesvirus replication and production of new infectious virions. Here, we examined how the essential Kaposi’s sarcoma-associated herpesvirus (KSHV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe87dfdfd8429f69154374b02a56be3
https://doi.org/10.1101/2023.05.01.538939
https://doi.org/10.1101/2023.05.01.538939
5-Azacytidine (aza-C) and its derivatives are cytidine analogues used for leukemia chemotherapy. The primary effect of aza-C is the prohibition of cytosine methylation, which results in covalent methyltransferase-DNA (MTase-DNA) adducts at cytosine m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fff534f6e3e726afbcef56e81d0fb36
https://doi.org/10.1158/0008-5472.c.6496527
https://doi.org/10.1158/0008-5472.c.6496527
Supplementary Figures 1-5 from 5-Azacytidine–Induced Methyltransferase-DNA Adducts Block DNA Replication In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cc24d8ec9beaedd71342f49c98f0cb
https://doi.org/10.1158/0008-5472.22370760.v1
https://doi.org/10.1158/0008-5472.22370760.v1