Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jack D, Rubien"'
Autor:
Pedro Ervilha Pereira, Nika Schuermans, Antoon Meylemans, Pontus LeBlanc, Lauren Versluys, Katie E. Copley, Jack D. Rubien, Christopher Altheimer, Myra Peetermans, Elke Debackere, Olivier Vanakker, Sandra Janssens, Jonathan Baets, Kristof Verhoeven, Martin Lammens, Sofie Symoens, Boel De Paepe, Sami J. Barmada, James Shorter, Jan L. De Bleecker, Elke Bogaert, Bart Dermaut
Publikováno v:
Acta neuropathologica
ACTA NEUROPATHOLOGICA
ACTA NEUROPATHOLOGICA
Neuronal TDP-43-positive inclusions are neuropathological hallmark lesions in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Pathogenic missense variants in TARDBP, the gene encoding TDP-43, can cause ALS and cluster in the C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce2536ee725ebb0ff9387b5a0fc0d42
https://doi.org/10.1007/s00401-023-02565-1
https://doi.org/10.1007/s00401-023-02565-1
Autor:
X. Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, H. Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D. Rubien, Karen Jansen-West, Casey N. Cook, Sarah Pickles, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, James Shorter, Sua Myong, Eric M. Green, William W. Seeley, Leonard Petrucelli, Aaron D. Gitler
Publikováno v:
Nature. 603:124-130
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f758b8c837195288f92794e856595a83
https://doi.org/10.1038/s41586-022-04424-7
https://doi.org/10.1038/s41586-022-04424-7
Autor:
X Rosa, Ma, Mercedes, Prudencio, Yuka, Koike, Sarat C, Vatsavayai, Garam, Kim, Fred, Harbinski, Adam, Briner, Caitlin M, Rodriguez, Caiwei, Guo, Tetsuya, Akiyama, H Broder, Schmidt, Beryl B, Cummings, David W, Wyatt, Katherine, Kurylo, Georgiana, Miller, Shila, Mekhoubad, Nathan, Sallee, Gemechu, Mekonnen, Laura, Ganser, Jack D, Rubien, Karen, Jansen-West, Casey N, Cook, Sarah, Pickles, Björn, Oskarsson, Neill R, Graff-Radford, Bradley F, Boeve, David S, Knopman, Ronald C, Petersen, Dennis W, Dickson, James, Shorter, Sua, Myong, Eric M, Green, William W, Seeley, Leonard, Petrucelli, Aaron D, Gitler
Publikováno v:
Nature, vol 603, iss 7899
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::821110b3bc35110fc73e4b0933142d1d
https://escholarship.org/uc/item/1062r1nd
https://escholarship.org/uc/item/1062r1nd
Autor:
Hana M. Odeh, Martina Hallegger, Aram G. Amalietti, Bo Lim Lee, Bede Portz, Nicholas M. Luscombe, Klara Kuret, Jack D. Rubien, James Shorter, Frédérique Rau, Nicolas L. Fawzi, Rickie Patani, Ina Huppertz, Jernej Ule, Katie E. Copley, Anob M. Chakrabarti, Flora C.Y. Lee
Publikováno v:
Cell, vol. 184, no. 18, pp. 4680-4696,e1-e22, 2021.
Cell
Cell
Summary Mutations causing amyotrophic lateral sclerosis (ALS) often affect the condensation properties of RNA-binding proteins (RBPs). However, the role of RBP condensation in the specificity and function of protein-RNA complexes remains unclear. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ed2633fd10b3a00dd40befabec71e0
https://dirros.openscience.si/Dokument.php?id=18781&dn=
https://dirros.openscience.si/Dokument.php?id=18781&dn=
Publikováno v:
Polymers
Polymers, Vol 11, Iss 1, p 83 (2019)
Volume 11
Issue 1
Polymers, Vol 11, Iss 1, p 83 (2019)
Volume 11
Issue 1
Polyelectrolyte complex micelles (PCMs, core-shell nanoparticles formed by complexation of a polyelectrolyte with a polyelectrolyte-hydrophilic neutral block copolymer) offer a solution to the critical problem of delivering therapeutic nucleic acids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf55acea27c9f65969b9c1f4073278f8
http://europepmc.org/articles/PMC6402004
http://europepmc.org/articles/PMC6402004
Polyelectrolyte complex micelles (PCMs, core-shell nanoparticles formed by complexation of a polyelectrolyte with a polyelectrolyte-hydrophilic neutral block polymer) offer an attractive solution to the critical problem of delivering therapeutic nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bf9d19140caa3fd8891357c8125414
https://doi.org/10.26434/chemrxiv.7456322.v1
https://doi.org/10.26434/chemrxiv.7456322.v1
Autor:
Michael L. Klein, Qi Xiao, Paul A. Heiney, Srujana S. Yadavalli, Sergei A. Vinogradov, Mark Goulian, Daniel A. Hammer, Ellen H. Reed, Tobias Baumgart, Jack D. Rubien, Samantha E. Wilner, Dipankar Sahoo, Virgil Percec, Zhichun Wang
Publikováno v:
Journal of the American Chemical Society. 138:12655-12663
The modular synthesis of a library containing seven self-assembling amphiphilic Janus dendrimers is reported. Three of these molecules contain environmentally friendly chiral-racemic fluorinated dendrons in their hydrophobic part (RF), one contains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd66142b7350202d65364be3321e15c2
https://doi.org/10.1021/jacs.6b08069
https://doi.org/10.1021/jacs.6b08069
Publikováno v:
Biophysical Journal. 118:223a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c7a7ce38a7b3cff8ddce6855f55064
https://doi.org/10.1016/j.bpj.2019.11.1321
https://doi.org/10.1016/j.bpj.2019.11.1321