Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jack C. de la Torre"'
Autor:
Jack C. de la Torre
Publikováno v:
Journal of Alzheimer's Disease. 79:1381-1396
This review examines new biomolecular findings that lend support to the hemodynamic role played by chronic brain hypoperfusion (CBH) in driving a pathway to Alzheimer’s disease (AD). CBH is a common clinical feature of AD and the current topic of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714b650463525783fb8906759d21a0e8
https://doi.org/10.3233/jad-201165
https://doi.org/10.3233/jad-201165
Autor:
Jack C. de la Torre
Publikováno v:
Journal of Alzheimer's Disease. 76:63-84
This review attempts to examine two key elements in the evolution of cognitive impairment in the elderly who develop heart failure. First, major left side heart parts can structurally and functionally deteriorate from aging wear and tear to provoke h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75848e54c6e41eaa16051f9ca5c8acc
https://doi.org/10.3233/jad-200296
https://doi.org/10.3233/jad-200296
Publikováno v:
Journal of Alzheimer's disease : JAD. 82(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9172659fa31e016aeb8d728250e55f13
https://pubmed.ncbi.nlm.nih.gov/34250943
https://pubmed.ncbi.nlm.nih.gov/34250943
Autor:
Jack C. de la Torre
Publikováno v:
Journal of Alzheimer's Disease. 57:353-371
There is growing evidence that chronic brain hypoperfusion plays a central role in the development of Alzheimer's disease (AD) long before dyscognitive symptoms or amyloid-β accumulation in the brain appear. This commentary proposes that dementia wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5878b4ddf7607c03a02a73c1f0717d0e
https://doi.org/10.3233/jad-161266
https://doi.org/10.3233/jad-161266
Publikováno v:
Neuropharmacology. 171
There is now substantial evidence that cerebral blood flow (CBF) declines with age. From age 20 to 60, CBF is estimated to dip about 16% and continues to drop at a rate of 0.4%/year. This CBF dip will slowly reduce oxygen/glucose delivery to brain th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe383d75dd51d3b8ed2659b358cd6ec
https://pubmed.ncbi.nlm.nih.gov/31704275
https://pubmed.ncbi.nlm.nih.gov/31704275
Autor:
Jack C. de la Torre
Publikováno v:
Brain Pathology. 26:618-631
Cardiovascular and cerebrovascular diseases are major risk factors in the development of cognitive impairment and Alzheimer's disease (AD). These cardio-cerebral disorders promote a variety of vascular risk factors which in the presence of advancing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e48ce73797a3d1ec6744e49a4ea2de
https://doi.org/10.1111/bpa.12405
https://doi.org/10.1111/bpa.12405
Autor:
Adrian Jorda, José M. Vila, Jack C. de la Torre, Antonio Iradi, Constanza Aldasoro, Juan Campos-Campos, Martin Aldasoro, Soraya L. Valles
Publikováno v:
Vallés Martí, Lílian Soraya Antonio Iradi Martin Aldasoro Jose M. Vila Constanza Aldasoro Jack de la Torre Juan Campos-Campos Adrian Jorda. 2019 Function of Glia in Aging and the Brain Diseases. International Journal Of Medical Sciences 16 11 1473 1479
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
International Journal of Medical Sciences
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
International Journal of Medical Sciences
Microglia cells during aging, neurodegeneration and neuroinflammation show different morphological and transcriptional profiles (related to axonal direction and cell adhesion). Furthermore, expressions of the receptors on the surface and actin format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb5c98298d03fb63d8d39ef6383c2c
https://hdl.handle.net/10550/74712
https://hdl.handle.net/10550/74712
Autor:
Jack C. de la Torre
Publikováno v:
Journal of Alzheimer's disease : JAD. 63(1)
The vascular hypothesis of Alzheimer's disease (VHAD) was proposed 24 years ago from observations made in our laboratory using aging rats subjected to chronic brain hypoperfusion. In recent years, VHAD has become a mother-lode to numerous neuroimagin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbe560abc1f09c339a9871000ebacd8
https://pubmed.ncbi.nlm.nih.gov/29614675
https://pubmed.ncbi.nlm.nih.gov/29614675
Autor:
Jack C. de la Torre
Publikováno v:
Journal of Alzheimer's Disease. 42:S431-S442
The incidence rate in Alzheimer's disease (AD) is expected to quadruple worldwide by 2050. To limit this impending socio-medical calamity, a fulcrum change from how AD is presently managed is crucial. The present approach has not averted the stress o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1a1a61b17bcb558aee0afb6f468891
https://doi.org/10.3233/jad-141560
https://doi.org/10.3233/jad-141560
Autor:
Jack C. de la Torre
This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer's before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackl