Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jack Bleesing"'
Autor:
Elena Palmisani, Maurizio Miano, Alice Grossi, Marina Lanciotti, Michela Lupia, Paola Terranova, Isabella Ceccherini, Eugenia Montanari, Michaela Calvillo, Filomena Pierri, Concetta Micalizzi, Rosario Maggiore, Daniela Guardo, Sabrina Zanardi, Elena Facchini, Angela Maggio, Elena Mastrodicasa, Paola Corti, Giovanna Russo, Marta Pillon, Piero Farruggia, Simone Cesaro, Angelica Barone, Francesca Tosetti, Ugo Ramenghi, Nicoletta Crescenzio, Jack Bleesing, Carlo Dufour, Francesca Fioredda
Publikováno v:
HemaSphere, Vol 7, Iss 3, p e845 (2023)
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder of lymphocyte homeostasis classically due to mutation of FAS, FASL, and CASP10 genes (ALPS-FAS/CASP10). Despite recent progress, about one-third of ALPS patients does not carry c
Externí odkaz:
https://doaj.org/article/c43c1c5cbfe24a589e2d78a06dda00dd
Autor:
Jack Bleesing
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In this article, we will share lessons that patients with gain-of-function defects in Toll-like receptor 8 (TLR8-GOF) can teach us about the interface between bone marrow failure (BMF) disorders and inborn errors of immunity (IEI), subsequently refer
Externí odkaz:
https://doaj.org/article/b712132c0e104c3b9183b5a1bacabf81
Autor:
Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing, Kasper Hoebe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β act
Externí odkaz:
https://doaj.org/article/09487aa202ff4465abb8756803164dd9
Autor:
Pooja Purswani, Cristina Adelia Meehan, Hye Sun Kuehn, Yenhui Chang, Joseph F. Dasso, Anna K. Meyer, Boglarka Ujhazi, Krisztian Csomos, David Lindsay, Taylor Alberdi, Sonia Joychan, Jessica Trotter, Carla Duff, Maryssa Ellison, Jack Bleesing, Attila Kumanovics, Anne M. Comeau, Jaime E. Hale, Luigi D. Notarangelo, Troy R. Torgersen, Hans D. Ochs, Panida Sriaroon, Benjamin Oshrine, Aleksandra Petrovic, Sergio D. Rosenzweig, Jennifer W. Leiding, Jolan E. Walter
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
In the era of newborn screening (NBS) for severe combined immunodeficiency (SCID) and the possibility of gene therapy (GT), it is important to link SCID phenotype to the underlying genetic disease. In western countries, X-linked interleukin 2 recepto
Externí odkaz:
https://doaj.org/article/7dff6da8b9b04db68c6c1cd6a8c8dac3
Autor:
Sharon L. Sauter, Xue Zhang, Lindsey Romick-Rosendale, Susanne I. Wells, Kasiani C. Myers, Marion G. Brusadelli, Charles B. Poff, Darron R. Brown, Gitika Panicker, Elizabeth R. Unger, Parinda A. Mehta, Jack Bleesing, Stella M. Davies, Melinda Butsch Kovacic
Publikováno v:
Cancers, Vol 13, Iss 6, p 1368 (2021)
High-risk human papillomavirus (HPV) is prevalent and known to cause 5% of all cancers worldwide. The rare, cancer prone Fanconi anemia (FA) population is characterized by a predisposition to both head and neck squamous cell carcinomas and gynecologi
Externí odkaz:
https://doaj.org/article/a50c2f426c1a4dd2a085554638921627
Autor:
Chen Wang, Bijun Sun, Kevin Wu, Jocelyn Farmer, Boglarka Ujhazi, Christoph B. Geier, Sumai Gordon, Emma Westermann-Clark, Sinisa Savic, Sargur Ravishankar, Karin Chen, Cullen M Dutmer, Maria G Kanariou, Mehdi Adeli, Paolo Palma, Carmem Bonfim, Evangelia Lycopoulou, Beata Wolska-Kusnierz, Dbaibo Ghassan, Jack Bleesing, Despina Moshous, Benedicte Neven, Catharina Schuetz, Geha Raif, Luigi D. Notarangelo, Maurizio Miano, David K. Buchbinder, Krisztian Csomos, Wenjie Wang, Ji-Yang Wang, Xiaochuan Wang, Jolan E. Walter
Publikováno v:
Blood. 140:2448-2450
Autor:
Sung-Yun Pai, Nisha Nagarsheth, Susan Prockop, Myriam Armant, Donald B. Kohn, Rebecca A. Marsh, Claire Booth, John K. Everett, Jack Bleesing, Deepak Chellapandian, Colleen Dansereau, Satiro de Oliveira, Wendy B. London, M. Angélica Marinovic, Theodore B. Moore, Matias Oleastro, Grainne O'Toole, Mark Vander Lugt, Luciano Urdinez, Kelly J. Walkovich, Jolan E. Walter, Axel Schambach, Adrian J. Thrasher, Frederic D. Bushman, David A Williams
Publikováno v:
Blood. 140:10643-10645
Publikováno v:
Journal of clinical immunology. 42(8)
Autor:
Andrew R, Patterson, Paige, Bolcas, Kristin, Lampe, Rachel, Cantrell, Brandy, Ruff, Ian, Lewkowich, Simon P, Hogan, Edith M, Janssen, Jack, Bleesing, Gurjit K, Khurana Hershey, Kasper, Hoebe
Publikováno v:
The Journal of allergy and clinical immunology. 143(1)
BACKGROUND: The GTPase of immunity-associated protein 5 is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 SNPs have been linked with an increased risk for asthma, while the loss of Gimap5 in mice has been associated with se
Publikováno v:
The Journal of Immunology. 198:212.14-212.14
The GTPase of immunity-associated protein 5 (Gimap5) has been linked with lymphocyte survival, autoimmunity and colitis development. Previous studies indicated that Gimap5-deficient mice exhibit a reduced lymphocyte proliferation and survival. Here w