Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jack Blazyk"'
Autor:
Riqiang Fu, Leah Cairns, Joseph Maramba, Fatih Comert, Sergei Sukharev, Roderico Acevedo, Laura Lucas, Thulasi Kulasinghe, Myriam Cotten, Mihaela Mihailescu, Jack Blazyk, Alexander I. Greenwood, Janet Hammer, Yi Wen
Publikováno v:
J Biol Chem
The host-defense peptide (HDP) piscidin 1 (P1), isolated from the mast cells of striped bass, has potent activities against bacteria, viruses, fungi, and cancer cells and can also modulate the activity of membrane receptors. Given its broad pharmacol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af92a21c1284dc4dd3a9d3260376e28
https://europepmc.org/articles/PMC6901303/
https://europepmc.org/articles/PMC6901303/
Autor:
Richard W. Pastor, Linda K. Nicholson, Vitalii Silin, Jolita Seckute, Janet Hammer, Mirco Sorci, Nedzada Smajic, Alexander I. Greenwood, Jorge I. Hernandez, B. Scott Perrin, Jack Blazyk, Riqiang Fu, Akritee Shrestha, Myriam Cotten, Kimberly A. Bogardus, Mihaela Mihailescu, Georges Belfort
Publikováno v:
J Am Chem Soc
Piscidins are histidine-enriched antimicrobial peptides that interact with lipid bilayers as amphipathic α-helices. Their activity at acidic and basic pH in vivo makes them promising templates for biomedical applications. This study focuses on p1 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1d24cf11230448c7142cf7bf273ed5
https://europepmc.org/articles/PMC7312726/
https://europepmc.org/articles/PMC7312726/
Autor:
Herman K. Lehman, Michael L. McCormick, M. Daben J. Libardo, Janet Hammer, Sophie E. Mayeux, Akritee Shrestha, Robert M. Hayden, Riqiang Fu, Alfredo M. Angeles-Boza, Sergey Pryshchep, Jack Blazyk, Mason Schoeneck, Bryan M. Ferguson, Myriam Cotten, Kimberly A. Bogardus, Gina K. Goldberg
Publikováno v:
The Journal of Physical Chemistry B. 119:15235-15246
Piscidins were the first antimicrobial peptides discovered in the mast cells of vertebrates. While two family members, piscidin 1 (p1) and piscidin 3 (p3), have highly similar sequences and α-helical structures when bound to model membranes, p1 gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb61a6f7585b5ec5bebe84e22494ed01
https://doi.org/10.1021/acs.jpcb.5b09685
https://doi.org/10.1021/acs.jpcb.5b09685
Autor:
Brian C. Clark, Jack Blazyk
Publikováno v:
Journal of Osteopathic Medicine. 114:608-614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02f83fae3510f22deffe40ebdbf1c66
https://doi.org/10.7556/jaoa.2014.124
https://doi.org/10.7556/jaoa.2014.124
Autor:
Brandon Kyriss, Eduard Y. Chekmenev, Michelle Pate, William W. Brey, Lorraine M. Homem, Mary J. Ellard-Ivey, Kristen T. Forseth, Joshua Raines, Breanna S. Vollmar, Peter L. Gor’kov, Myriam Cotten, Shiela M. Jones, RaeLynn M. Endicott, Tim J. Wagner, Dan J. Mitchell, Jing He, Jack Blazyk, McKenna N. Manion, Ann J. Auman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1758(9):1359-1372
We studied amidated and non-amidated piscidins 1 and 3, amphipathic cationic antimicrobial peptides from fish, to characterize functional and structural similarities and differences between these peptides and better understand the structural motifs i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94c0c8402d6094993df4bec28cb205c
Publikováno v:
Biophysical Journal. 87(1):662-674
The chemical shifts of specific (13)C and (15)N labels distributed throughout KIAGKIA-KIAGKIA-KIAGKIA (K3), an amphiphilic 21-residue antimicrobial peptide, prove that the peptide is in an all alpha-helical conformation in the bilayers of multilamell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51a7af261dfde929bab62fbdbbb728a
Autor:
Nancy Lazaro, Jacob Schaefer, Joan M. Boggs, Jack Blazyk, Thomas J. McIntosh, Lee R. Wright, Donald J. Hirsh
Publikováno v:
Biophysical Journal. 75:1858-1868
16-Fluoropalmitic acid was synthesized from 16-hydroxypalmitic acid using diethylaminosulfur trifluoride. This monofluorinated fatty acid then was used to make 1-palmitoyl-2-[16-fluoropalmitoyl]-phosphatidylcholine (F-DPPC) as a fluorinated analog of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e10ff9fc7395997cd26970d3766b076
https://doi.org/10.1016/s0006-3495(98)77626-x
https://doi.org/10.1016/s0006-3495(98)77626-x
Publikováno v:
Biochemistry. 37:13791-13799
We investigated the interaction of the antimicrobial peptides Ala19-magainin 2 amide and magainin 2 amide with lipid using two lipid photolabels, azidobenzoyl galactosylceramide (GalCer-PL) and azidobenzoylamido capryloyl galactosylceramide (GalCer-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd968ad5ee6d74f38248556603f3af70
https://doi.org/10.1021/bi980855c
https://doi.org/10.1021/bi980855c
Publikováno v:
Biological and Pharmaceutical Bulletin. 28:148-150
Using a surface plasmon resonance (SPR) system, we investigated the lipid membrane-binding properties of four analogues of the 18-residue linear amphipathic beta-sheet cationic antimicrobial peptide (KIGAKI)3-NH2, each of which contains a single isol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a3858b95eae3253ec9a737d3e90f4e
https://doi.org/10.1248/bpb.28.148
https://doi.org/10.1248/bpb.28.148
Publikováno v:
Biochemistry. 35:12733-12741
Magainins are cationic, membrane-active peptides which show broad-spectrum antimicrobial activity. We have investigated the secondary structure and location of an analogue of magainin 2 in synthetic phospholipid bilayers using a combination of Fourie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5713ecfc281a76096ddb89b05d572d
https://doi.org/10.1021/bi961468a
https://doi.org/10.1021/bi961468a