Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jack Bartram"'
Autor:
Michelle Bishop, Aditi Vedi, Sarah Bowdin, Ruth Armstrong, Jack Bartram, David Bentley, Mark Ross, C. Elizabeth Hook, Brian Hon Yin Chung, Parker Moss, David H. Rowitch, Patrick Tarpey, Sam Behjati, Matthew J. Murray
Publikováno v:
BMC Medical Education, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background The clinical utility of whole genome sequencing (WGS) in paediatric cancer has been demonstrated in recent years. WGS has been routinely available in the National Health Service (NHS) England for all children with cancer in Englan
Externí odkaz:
https://doaj.org/article/b596a2e9f4594a5cbc378334e4100a46
Autor:
Macarena Oporto Espuelas, Saskia Burridge, Amy A. Kirkwood, Denise Bonney, Kelly Watts, Geoff Shenton, Katarzyna A. Jalowiec, Maeve A. O’Reilly, Claire Roddie, Anna Castleton, Katherine Clesham, Emma Nicholson, Rajesh Alajangi, Shilpa Prabhu, Lindsay George, Ben Uttenthal, Maria Gabelli, Lorna Neill, Caroline Besley, Sridhar Chaganti, Robert F. Wynn, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Juliana Silva, Sujith Samarasinghe, Ajay Vora, Peter Clark, Michelle Cummins, David I. Marks, Persis Amrolia, Rachael Hough, Sara Ghorashian
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract CAR T-cell therapy has transformed relapsed/refractory (r/r) B-cell precursor acute lymphoblastic leukaemia (B-ALL) management and outcomes, but following CAR T infusion, interventions are often needed. In a UK multicentre study, we retrospe
Externí odkaz:
https://doaj.org/article/1e1c7d0bb80d4261a46effd3f77c1a63
Autor:
Jonathan Mitchell, Salvatore Milite, Jack Bartram, Susan Walker, Nadezda Volkova, Olena Yavorska, Magdalena Zarowiecki, Jane Chalker, Rebecca Thomas, Luca Vago, Alona Sosinsky, Giulio Caravagna
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The unexpected contamination of normal samples with tumour cells reduces variant detection sensitivity, compromising downstream analyses in canonical tumour-normal analyses. Leveraging whole-genome sequencing data available at Genomics Engla
Externí odkaz:
https://doaj.org/article/6982e7ee6f034f499acae6eb4a4c3fee
Autor:
Samuele Renzi, Fatimah Algawahmed, Scott Davidson, Karin P. S. Langenberg, Fabio Fuligni, Salah Ali, Nathaniel Anderson, Ledia Brunga, Jack Bartram, Mohamed Abdelhaleem, Ahmed Naqvi, Kassa Beimnet, Andre Schuh, Anne Tierens, David Malkin, Adam Shlien, Mary Shago, Anita Villani
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 5946-5952 (2023)
ETV6-ABL1 gene fusion is a rare genetic rearrangement in a variety of malignancies, including myeloproliferative neoplasms (MPN), acute lymphoblastic leukemia (ALL), and acute myeloid leukemia (AML). Here, we report the case of a 16-year-old male dia
Externí odkaz:
https://doaj.org/article/a592fb16ae0b494781fe3064b7d6424d
Autor:
Luca Gasparoli, Clemence Virely, Alexia Tsakaneli, Noelia Che, Darren Edwards, Jack Bartram, Michael Hubank, Deepali Pal, Olaf Heidenreich, Joost H.A. Martens, Jasper de Boer, Owen Williams
Publikováno v:
Haematologica, Vol 109, Iss 4 (2023)
Advances in the clinical management of pediatric B-cell acute lymphoblastic leukemia (B-ALL) have dramatically improved outcomes for this disease. However, relapsed and high-risk disease still contribute to significant numbers of treatment failures.
Externí odkaz:
https://doaj.org/article/aa3599b620044cacb18115d1719e17ca
Autor:
Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicat
Externí odkaz:
https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396
Autor:
Amna Malik, Eszter N Tóth, Michelle S Teng, Jacob Hurst, Eleanor Watt, Lauren Wise, Natalie Kent, Jack Bartram, Louis Grandjean, Margarita Dominguez-Villar, Stuart Adams, Nichola Cooper
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0274289 (2022)
While the majority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) display mild or no symptoms, rare individuals develop severe disease presenting with multisystem inflammatory syndrome (MIS-C). The reason for v
Externí odkaz:
https://doaj.org/article/3967135dd2e14b99b51011cd3b998cf0
ARHGEF4 Regulates an Essential Oncogenic Program in t(12;21)-Associated Acute Lymphoblastic Leukemia
Autor:
Clemence Virely, Luca Gasparoli, Maurizio Mangolini, Katherine Clesham, Sarah Inglott, Darren Edwards, Stuart Adams, Jack Bartram, Sujith Samarasinghe, Philip Ancliff, Ajay Vora, Jasper de Boer, Owen Williams
Publikováno v:
HemaSphere, Vol 4, Iss 5, p e467 (2020)
Externí odkaz:
https://doaj.org/article/ba127412a40e48b59ab4563b710bbd5e
Autor:
Jack Bartram, Nick Goulden, Gary Wright, Stuart Adams, Tony Brooks, Darren Edwards, Sarah Inglott, Yasar Yousafzai, Mike Hubank, Christina Halsey
Publikováno v:
Haematologica, Vol 103, Iss 3 (2018)
Externí odkaz:
https://doaj.org/article/df52f9e744354f35979c3b15b766a240
Autor:
Colin R. Deane, David Goss, Jack Bartram, Keith R.E. Pohl, Susan E. Height, Naomi Sibtain, Jozef Jarosz, Swee Lay Thein, David C. Rees
Publikováno v:
Haematologica, Vol 95, Iss 8 (2010)
Background Sickle cell anemia is one of the commonest causes of stroke in children. It is usually, but not always, associated with intracranial vasculopathy. We have assessed the value of ultrasound screening for extracranial internal carotid artery
Externí odkaz:
https://doaj.org/article/0eca3d3ef28749638cf9293b52b492e9