Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jack Atmaj"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 263-281 (2019)
Protein-protein interaction (PPI) is a hot topic in clinical research as protein networking has a major impact in human disease. Such PPIs are potential drugs targets, leading to the need to inhibit/block specific PPIs. While small molecule inhibitor
Externí odkaz:
https://doaj.org/article/5954f963957a435bb2f064d34f1eb4dc
Exploring the Surface of the Ectodomain of the PD-L1 Immune Checkpoint with Small-Molecule Fragments
Autor:
Radoslaw Kitel, Ismael Rodríguez, Xabier del Corte, Jack Atmaj, Magdalena Żarnik, Ewa Surmiak, Damian Muszak, Katarzyna Magiera-Mularz, Grzegorz M. Popowicz, Tad A. Holak, Bogdan Musielak
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
ACS Chem. Biol. 17, 2655-2663 (2022)
Universidad de Cantabria (UC)
ACS Chem. Biol. 17, 2655-2663 (2022)
Development of small molecules targeting the PD-L1/PD-1 interface is advancing both in industry and academia, but only a few have reached early-stage clinical trials. Here, we take a closer look at the general druggability of PD-L1 using in silico ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e345513babc5dad35ea5c6ee45ce5d
http://hdl.handle.net/10810/58248
http://hdl.handle.net/10810/58248
Autor:
Tad A. Holak, Alexander Dömling, Ran Zhang, Constantinos G. Neochoritis, Daniel G. Rivera, Ewa Surmiak, Matthew Groves, Jacek Plewka, Lukasz Skalniak, Beata Labuzek, Ameena M Ali, Manuel G. Ricardo, Jack Atmaj
Publikováno v:
Angewandte Chemie (International ed. in English), 59(13), 5235-5241. WILEY-V C H VERLAG GMBH
Stapled peptides are chemical entities in-between biologics and small molecules, which have proven to be the solution to high affinity protein–protein interaction antagonism, while keeping control over pharmacological performance such as stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0769ba57d31d9c62f8a107a610f30806
https://research.rug.nl/en/publications/1eed797b-c10f-4401-9039-feefae3bb9b6
https://research.rug.nl/en/publications/1eed797b-c10f-4401-9039-feefae3bb9b6
Autor:
Alexander Dömling, Aleksandra Twarda-Clapa, Lisa-Maria Köhler, Lukasz Skalniak, Barbara Beck, Jack Atmaj, Damian Muszak, Tad A. Holak, Justyna Kalinowska-Tłuścik, Ewa Surmiak, Katarzyna Kurpiewska, Constantinos G. Neochoritis
Publikováno v:
European Journal of Medicinal Chemistry, 182:111588. ELSEVIER MASSON, CORPORATION OFFICE
Intrinsically disordered proteins are an emerging class of proteins without a folded structure and currently disorder-based drug targeting remains a challenge. p53 is the principal regulator of cell division and growth whereas MDM2 consists its main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dc866e2b5a4f6c1515ca29823f4824
https://europepmc.org/articles/PMC7008132/
https://europepmc.org/articles/PMC7008132/
Autor:
Matthew Groves, Sun Rei Yan, Ameena M Ali, Niels van Oosterwijk, Jack Atmaj, Sergey Lunev, Alaa Adawy, Chris Williams
Publikováno v:
Acta Crystallographica Section F: Structural Biology Communications, 74(Pt 2):ISSN 2053-230X, 76-81. INT UNION CRYSTALLOGRAPHY
Peroxisomes are a major cellular compartment of eukaryotic cells, and are involved in a variety of metabolic functions and pathways according to species, cell type and environmental conditions. Their biogenesis relies on conserved genes known asPEXge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fd3b4706a6be22c511c82156cb3388
https://research.rug.nl/en/publications/d742ed22-da09-4d26-8dcd-5874380562e4
https://research.rug.nl/en/publications/d742ed22-da09-4d26-8dcd-5874380562e4