Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Jack A. Wells"'
Autor:
Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe, Ian F. Harrison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. These
Externí odkaz:
https://doaj.org/article/65c062308a814af1b6467b6b5609aa1e
Autor:
Isabel N. Christie, Shefeeq M. Theparambil, Alice Braga, Maxim Doronin, Patrick S. Hosford, Alexey Brazhe, Alexander Mascarenhas, Shereen Nizari, Anna Hadjihambi, Jack A. Wells, Adrian Hobbs, Alexey Semyanov, Andrey Y. Abramov, Plamena R. Angelova, Alexander V. Gourine
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113514- (2023)
Summary: During hypoxia, increases in cerebral blood flow maintain brain oxygen delivery. Here, we describe a mechanism of brain oxygen sensing that mediates the dilation of intraparenchymal cerebral blood vessels in response to reductions in oxygen
Externí odkaz:
https://doaj.org/article/e103ac5e3e2a45a0b6df0577e2df1764
Autor:
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Iván Ruminot, Mark F. Lythgoe, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.
Externí odkaz:
https://doaj.org/article/0e7fd82c54eb4eecb447c0bf5d5c893f
Autor:
Charith Perera, Daniele Tolomeo, Rebecca R. Baker, Yolanda Ohene, Alla Korsak, Mark F. Lythgoe, David L. Thomas, Jack A. Wells
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Chronic hypertension is a major risk factor for the development of neurodegenerative disease, yet the etiology of hypertension-driven neurodegeneration remains poorly understood. Forming a unique interface between the systemic circulation and the bra
Externí odkaz:
https://doaj.org/article/a9cfb96988374a9fa538e5809e844fa7
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Vascular dysregulation and cholinergic basal forebrain degeneration are both early pathological events in the development of Alzheimer’s disease (AD). Acetylcholine contributes to localised arterial dilatation and increased cerebral blood
Externí odkaz:
https://doaj.org/article/ee868e90148f4c68b184f20760ef4db9
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298
Autor:
Yichao Yu, Christopher Payne, Nephtali Marina, Alla Korsak, Paul Southern, Ana García‐Prieto, Isabel N. Christie, Rebecca R. Baker, Elizabeth M. C. Fisher, Jack A. Wells, Tammy L. Kalber, Quentin A. Pankhurst, Alexander V. Gourine, Mark F. Lythgoe
Publikováno v:
Advanced Science, Vol 9, Iss 6, Pp n/a-n/a (2022)
Abstract Astrocytes play crucial and diverse roles in brain health and disease. The ability to selectively control astrocytes provides a valuable tool for understanding their function and has the therapeutic potential to correct dysfunction. Existing
Externí odkaz:
https://doaj.org/article/3d7a471dc06340348c33afdea1613ef6
Autor:
Leonie Petitclerc, Lydiane Hirschler, Jack A. Wells, David L. Thomas, Marianne A.A. van Walderveen, Mark A. van Buchem, Matthias J.P. van Osch
Publikováno v:
NeuroImage, Vol 245, Iss , Pp 118755- (2021)
The study of brain clearance mechanisms is an active area of research. While we know that the cerebrospinal fluid (CSF) plays a central role in one of the main existing clearance pathways, the exact processes for the secretion of CSF and the removal
Externí odkaz:
https://doaj.org/article/1aa4f9ffc350416f93765d4156a4833b
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118270- (2021)
Pharmacological MRI (phMRI) studies seek to capture changes in brain haemodynamics in response to a drug. This provides a methodological platform for the evaluation of novel therapeutics, and when applied to disease states, may provide diagnostic or
Externí odkaz:
https://doaj.org/article/1c64b95143cd45d29d34970ee572f2b7
Autor:
Patrick S. Hosford, Jack A. Wells, Isabel N. Christie, Mark F. Lythgoe, Julian Millar, Alexander V. Gourine
Publikováno v:
Biosensors and Bioelectronics: X, Vol 3, Iss , Pp 100034- (2019)
A method for simultaneous electrochemical detection of brain tissue PO2 (PtO2) and pH changes together with neuronal activity using a modified form of fast cyclic voltammetry with carbon fiber electrodes is described. This technique has been develope
Externí odkaz:
https://doaj.org/article/5b3aab60e5f1482f8fb6cc3b7111df8c