Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jack A. Grebb"'
Publikováno v:
International Clinical Psychopharmacology. 12:S3-10
Since the introduction in 1993 of the novel serotonin-dopamine antagonist antipsychotic risperidone, over 12 million patient-months of exposure to the drug have been accumulated. Further studies have confirmed the efficacy of risperidone across a bro
Autor:
Vladimir Coric, Joseph Pultz, Eileen Emison, Howard Feldman, Randy C. Dockens, Anantha Shekhar, Bernadette B. D'Souza, Jack A. Grebb, Shu-Pang Huang, Xiaoling Wu, Andrew Goddard, Daniel L. Zimbroff, Elyse Stock, Kimberly A. Gentile, Dan A. Oren, Terrye Aigeldinger Delmonte
Publikováno v:
Depression and anxiety. 27(5)
Background: Antagonism of corticotropin-releasing factor (CRF) receptors has been hypothesized as a potential target for the development of novel anxiolytics. This study was designed to determine the safety and efficacy of pexacerfont, a selective CR
Autor:
Katherine A. Albert, Paul Greengard, Jack A. Grebb, Neal L. Rosen, Hilary Blumberg, Göran Sedvall, Neil E. Anderson, Jerome B. Posner, Roger J. Porter, Sam Gandy, Orrin Devinsky, Jesse M. Cedarbaum
Publikováno v:
Annals of Neurology. 28:829-833
The components of protein phosphorylation systems (protein kinases, protein phosphatases, and their phosphoprotein substrates) are highly enriched in neuronal cells compared with other cell types. We exploited this relative neuronal enrichment of pro
Autor:
Jack A. Grebb, Paul Greengard
Publikováno v:
Archives of general psychiatry. 47(12)
Synapsin II (formerly known as protein III) is a synaptic vesicle-associated neuronal phosphoprotein that may be involved in the regulation of neurotransmitter release. Synapsin II was studied in postmortem brain samples from 132 individuals with var
Publikováno v:
Journal of neurochemistry. 55(1)
DARPP-32 (dopamine- and cyclic AMP-regulated phosphoprotein, Mr = 32,000, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) is a neuronal phosphoprotein that is enriched in neurons which possess dopamine D1 receptors, partic
Autor:
Jack A. Grebb, Jan Gheuens
Publikováno v:
Journal of Clinical Psychopharmacology. 18:176-177
Autor:
Jack A. Grebb
Publikováno v:
International Clinical Psychopharmacology. 12:S1-2
Publikováno v:
Alcoholism: Clinical and Experimental Research. 13:673-679
Protein phosphorylation is a primary mechanism of intracellular signal transduction, and abnormalities in protein phosphorylation have been implicated in the pathogenesis of several specific diseases. Protein III is a neuronal phosphoprotein that is
Publikováno v:
Comprehensive Psychiatry, Vol 25, Iss 2, Pp 216-224 (1984)
The authors present a pattern of electrophysiologic abnormalities from a computer-analyzed, electroencephalogram (EEG) and averaged evoked potential (AEP) test battery used in the assessment of a group of patients with eating disorders. This finding
Publikováno v:
Pharmacology Biochemistry and Behavior. 23:613-618
Sixteen calcium channel inhibitors (CCI's) were tested in a model utilizing phencyclidine (PCP)-induced behavioral stimulation in mice. There were marked differences in the effects of CCI's both within subclasses and between subclasses of CCI's. All