Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jack A. Dempsey"'
Autor:
David A. Schaer, Richard P. Beckmann, Jack A. Dempsey, Lysiane Huber, Amelie Forest, Nelusha Amaladas, Yanxia Li, Ying Cindy Wang, Erik R. Rasmussen, Darin Chin, Andrew Capen, Carmine Carpenito, Kirk A. Staschke, Linda A. Chung, Lacey M. Litchfield, Farhana F. Merzoug, Xueqian Gong, Philip W. Iversen, Sean Buchanan, Alfonso de Dios, Ruslan D. Novosiadly, Michael Kalos
Publikováno v:
Cell Reports, Vol 22, Iss 11, Pp 2978-2994 (2018)
Summary: Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast cancer. In this study, we use murine syngeneic tumor models and in vitro assays to inves
Externí odkaz:
https://doaj.org/article/1595454cd7fc4830988cdc917336d3e6
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab9e588f7270d239b69faebcc24e90
https://doi.org/10.1158/1535-7163.22506969.v1
https://doi.org/10.1158/1535-7163.22506969.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aca539a9e32036f4566410352eeff32
https://doi.org/10.1158/1535-7163.c.6538536.v1
https://doi.org/10.1158/1535-7163.c.6538536.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b687d979fb87e1752e656129b11b4a8
https://doi.org/10.1158/1535-7163.22506966
https://doi.org/10.1158/1535-7163.22506966
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9753ae2ef1911fad6be7d03eb93839c9
https://doi.org/10.1158/1535-7163.22506972.v1
https://doi.org/10.1158/1535-7163.22506972.v1
Autor:
Samuel McNeely, Xin Tian You, Ann M. McNulty, Sean Buchanan, Wayne Blosser, Yue Webster, Gregory P. Donoho, Farhana F. Merzoug, Ricardo Martinez, Philip J. Ebert, Karsten Boehnke, Aimee Bence Lin, Xi Rao, Philip W. Iversen, Xueqian Gong, Richard P. Beckmann, Wenjuan Wu, Jack A. Dempsey, Chunping Yu, Caitlin D. Lowery
Publikováno v:
Oncotarget
The combined influence of oncogenic drivers, genomic instability, and/or DNA damage repair deficiencies increases replication stress in cancer. Cells with high replication stress rely on the upregulation of checkpoints like those governed by CHK1 for
Autor:
Xueqian Gong, Karsten Boehnke, Carmen Baquero, Yue-Wei Qian, Gregory P. Donoho, Jason Manro, Robert T. Foreman, Carlos Marugán, Sonya C. Chapman, Yi Zeng, Phillip W Iversen, Jack A. Dempsey, Matthew Z. Dieter, David Anthony Barda, Henry James Robert, Michele Dowless, Shripad V. Bhagwat, Robert M. Campbell, Andrew Capen, Robert D. Van Horn, Amit Aggarwal, Mark S. Marshall, Darlene S. Barnard, Bharvin K. R. Patel, Louis Stancato, Huimin Bian, Li-Chun Chio, Sean Buchanan, Jian Du, Richard P. Beckmann, Christoph Reinhard, Ricardo Martinez, Gregory D. Plowman, Lei Yan, Shobha N. Bhattachar, Sarah M. Bogner, Maria Jose Lallena, Xiang S. Ye, Jennie L. Walgren, Yu-Hua Hui, Yue Webster, Emiko L. Kreklau, Raquel Torres, Yanzhu Yang, Bartley W. Halstead, Shaoyou Chu
Publikováno v:
Molecular Cancer Therapeutics. 18:2207-2219
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Autor:
Louis Stancato, Philip J. Ebert, Yue Webster, Alle B VanWye, Robert S. Flack, Xueqian Gong, Sean Buchanan, Caitlin D. Lowery, Jack A. Dempsey, Terry J Shackleford, Michele Dowless, Jennifer R. Stephens, Jonathan B. Olsen, Peter J. Houghton, Matthew Renschler, Philip W. Iversen, Wayne Blosser, Simone Gupta, Julie Stewart
Publikováno v:
Clinical Cancer Research. 24:6028-6039
Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The EWS/ETS fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate
BACKGROUND Ongoing research is necessary to better understand the causes of autism spectrum disorder (ASD), the developmental outcomes for individuals diagnosed with ASD, and the efficacy of the interventions. However, it is often difficult to recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eda96aa282279a7e853e72cf06e19773
https://doi.org/10.2196/preprints.16752
https://doi.org/10.2196/preprints.16752
Autor:
Wayne Blosser, Constance King, David Anthony Barda, Jack A. Dempsey, Darlene S. Barnard, Richard P. Beckmann, Samuel McNeely, Mark S. Marshall, H. Bruce Diaz
Publikováno v:
Molecular Cancer Therapeutics. 14:2004-2013
CHK1 is a multifunctional protein kinase integral to both the cellular response to DNA damage and control of the number of active replication forks. CHK1 inhibitors are currently under investigation as chemopotentiating agents due to CHK1's role in e