Zobrazeno 1 - 10 of 81 pro vyhledávání: '"Jack A. Alhadeff"'
1
Assessment of Potential Cross-Reactivity of Human Endogenous Matrix Metalloproteinases with Collagenase Clostridium histolyticum Antibodies in Human Sera Obtained from Patients with Dupuytren's Contracture
Autor: Benjamin J. Del Tito, Roland Koller-Eichhorn, Thomas J. Edkins, Ulrich Mayer, Jack A. Alhadeff, Heinrich Faust
Publikováno v: Clinical and Vaccine Immunology. 19:562-569
Collagenase Clostridium histolyticum (CCH) contains a fixed ratio of class I (AUX-I) and class II (AUX-II) collagenases and is used as treatment for Dupuytren's contracture. These two Zn-dependent enzymes, produced by the Gram-positive bacterium Clos
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc293bd9330209dbb9aaed5e387557d7
https://doi.org/10.1128/cvi.00018-12
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2
Purification and characterization of altered cystic fibrosis liver α-L-fucosidase
Autor: Patricia Watkins, Jack A. Alhadeff, Hud Freeze
Publikováno v: Clinical Genetics. 13:417-424
alpha-L-Fucosidase (E.C.3.2.4.51) from two cystic fibrosis livers has been purified and characterized. Purification was accomplished by an affinity chromatographic procedure previously used for normal liver alpha-L-fucosidase. Characterization of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa0e82c57c976ee3c4a93c59eeea8d11
https://doi.org/10.1111/j.1399-0004.1978.tb04141.x
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3
Altered isoenzyme patterns of liver α-L-fucosidase in cystic fibrosis
Autor: Jack A. Alhadeff, Linda L. Tennant, John S. O'Brien
Publikováno v: Clinical Genetics. 10:63-72
The isoenzyme pattern of alpha-L-fucosidase was studied by isoelectric focusing in livers from seven patients with cystic fibrosis and in normal and pathological (GM1-gangliosidosis, Type II and Sanfilippo disease) controls. The controls had very rep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ea804ace240f290ff384c927744052
https://doi.org/10.1111/j.1399-0004.1976.tb00014.x
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5
Human amniotic fluid CX-L-fucosidase
Autor: Grai L. Andrews-Smtth, Jack A. Alhadeff
Publikováno v: Clinical Genetics. 16:357-363
The activity and properties of alpha-L-fucosidase in 24 samples of amniotic fluid have been investigated using the 4-methylumbelliferyl substrate. A wide range of fucosidase specific activity (0.20-1.45 nmol/min/mg protein) was found with an average
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b8778a56dde37ce39b8ad4e4fcd842e
https://doi.org/10.1111/j.1399-0004.1979.tb01016.x
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7
Purification and Characterization of Plasma Membrane-Associated Human Sperm α-L-Fucosidase1
Autor: Sumpars Khunsook, Jack A. Alhadeff, Susan Rose McGowan, Barry S. Bean
Publikováno v: Biology of Reproduction. 68:709-716
Detergent and salt extraction studies, as well as cytochemical localization with fluorescein isothiocyanate-bovine serum albumin-l-fucose, have provided further evidence for the plasma membrane association of a novel human sperm, α-l-fucosidase. Thi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7af03d96038ee2454fa50114f5aaf41
https://doi.org/10.1095/biolreprod.102.004465
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8
Alteration of the isoform composition of plasma-membrane-associated rat sperm α-l-fucosidase during late epididymal maturation: comparative characterization of the acidic and neutral isoforms
Autor: Manuel Avilés, José A. Martínez-Menárguez, José Ballesta, Jack A. Alhadeff, Sheri R. Skalaban, Karen M. Grimm, Maria Teresa Castells, Irene Abascal
Publikováno v: ResearcherID
In a previous study, evidence was provided for the presence of a novel plasma-membrane-associated neutral-pH-optimum alpha-L-fucosidase in rat sperm. In the present study, rat sperm alpha-L-fucosidase was characterized during epididymal maturation. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13d563a4def6af94b45b96f125ec32e
https://doi.org/10.1042/bj3330201
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9
Purification and Characterization of Cathepsin D from Normal Human Breast Tissue
Autor: Nimisha P. Patel, Lorinda M. Wright, Jack A. Alhadeff, Erik Levy
Publikováno v: Journal of Protein Chemistry. 16:171-181
The lysosomal aspartyl protease cathepsin D is present in most mammalian cells and is active in the catabolism of intracellular and endocytosed proteins. It appears to be overexpressed and abnormally secreted in breast cancer cells, and may contribut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5329d5788ab739c602a891ee985307e1
https://doi.org/10.1023/a:1026322707644
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10
Development and validation of novel enzyme activity methods to assess inhibition of matrix metalloproteinases (MMPs) in human serum by antibodies against enzyme therapeutics
Autor: Charles Kalensky, Vincent Kwok, Benjamin J. Del Tito, Marie T. Rock, Jack A. Alhadeff, Thomas J. Edkins, Thomas J. Vidmar
Publikováno v: Journal of pharmaceutical and biomedical analysis. 70
This paper summarizes the development and validation of five enzyme activity methods to assess the specific inhibition of human endogenous matrix metalloproteinases MMP-1 (interstitial collagenase), MMP-2 (gelatinase A), MMP-3 (stromelysin 1), MMP-8
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5839b46a1601763081314b2094fe66
https://pubmed.ncbi.nlm.nih.gov/22854133
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