Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Jack A. Hinson"'
Autor:
Sudip Banerjee, Stepan B. Melnyk, Kimberly J. Krager, Nukhet Aykin-Burns, Sandra S. McCullough, Laura P. James, Jack A. Hinson
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 134-142 (2017)
The hepatotoxicity of acetaminophen (APAP) occurs by initial metabolism to N-acetyl-p-benzoquinone imine which depletes GSH and forms APAP-protein adducts. Subsequently, the reactive nitrogen species peroxynitrite is formed from nitric oxide (NO) and
Externí odkaz:
https://doaj.org/article/ea8551acea1042f8b335c8cacc3fbe9b
Autor:
Jack A. Hinson, Mitchell R. McGill
Publikováno v:
Drug Metab Rev
Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market approximately 65 years ago. Since then, it has become one of the most used drugs in the world. However, it is also a major cause of acute liver failure. Early investigati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb26e54b4afe1f0518f971fea5cb7c0
https://europepmc.org/articles/PMC8427730/
https://europepmc.org/articles/PMC8427730/
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35098 (2012)
Because of its low relative folding rate and plentiful manufacture in β-cells, proinsulin maintains a homeostatic balance of natively and plentiful non-natively folded states (i.e., proinsulin homeostasis, PIHO) through the integration of maturation
Externí odkaz:
https://doaj.org/article/c7288051502d4b4381b08b8cd5edaa9b
Acetaminophen liver injury is the most common cause of acute liver injury in the United States and several other countries. Diagnosis of acetaminophen-induced acute liver injury in the clinic is challenging due to the lack of validated and specific b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe74958c47fa5526db7cb3e61df5a536
https://doi.org/10.1016/bs.acc.2020.02.002
https://doi.org/10.1016/bs.acc.2020.02.002
Autor:
Nukhet Aykin-Burns, Lynda Letzig, Stepan Melnyk, Jack A. Hinson, Kimberly J. Krager, Sudip Banerjee, Laura P. James
Publikováno v:
Free Radical Biology and Medicine. 89:750-757
3-Nitrotyrosine (3NT) in liver proteins of mice treated with hepatotoxic doses of acetaminophen (APAP) has been postulated to be causative in toxicity. Nitration is by a reactive nitrogen species formed from nitric oxide (NO). The source of the NO is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f085864a11ec276bc3a30e00a5225d
https://doi.org/10.1016/j.freeradbiomed.2015.09.022
https://doi.org/10.1016/j.freeradbiomed.2015.09.022
Autor:
Sudeepa Bhattacharyya, Lisa Pence, Sandra S. McCullough, Shubhra Chaudhuri, Leah Hennings, Richard D. Beger, Pippa Simpson, Jack A. Hinson, Ke Yan, Laura P. James
Publikováno v:
Metabolites
Metabolites, Vol 3, Iss 3, Pp 606-622 (2013)
Metabolites; Volume 3; Issue 3; Pages: 606-622
Metabolites, Vol 3, Iss 3, Pp 606-622 (2013)
Metabolites; Volume 3; Issue 3; Pages: 606-622
High doses of acetaminophen (APAP) result in hepatotoxicity that involves metabolic activation of the parent compound, covalent binding of the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI) to liver proteins, and depletion of hepatic glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a60d45ba5df08effa04108266b6ef1
http://europepmc.org/articles/PMC3901280
http://europepmc.org/articles/PMC3901280
Autor:
Jack A. Hinson, Shasha Bai, Lynda Letzig, Daniel Ganger, Jody Rule, R. Todd Stravitz, Adrian Reuben, Robert J. Fontana, Christopher J. Swearingen, Oren K. Fix, Dean W. Roberts, Laura P. James, William M. Lee, Iris Liou, K. Rajender Reddy, Pippa Simpson
Publikováno v:
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 15(4)
A rapid and reliable point-of-care assay to detect acetaminophen protein adducts in the serum of patients with acute liver injury could improve diagnosis and management. AcetaSTAT is a competitive immunoassay used to measure acetaminophen protein add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698c07c839e0317adf800aac80b5c757
https://pubmed.ncbi.nlm.nih.gov/28017841
https://pubmed.ncbi.nlm.nih.gov/28017841
Autor:
Dean W. Roberts, Xi Yang, Qiang Shi, Levan Muskhelishvili, William F. Salminen, Kelly Davis, James Greenhaw, Jack A. Hinson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 344:286-294
Acetaminophen (APAP)-induced liver injury is the leading cause of acute liver failure in many countries. This study determined the extent of liver protein sulfhydryl depletion not only in whole liver homogenate but also in the zonal pattern of sulfhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4e4e1085a79691eafb21be01d4fff9
https://doi.org/10.1124/jpet.112.199067
https://doi.org/10.1124/jpet.112.199067
Autor:
Jack A. Hinson, Shubhra Chaudhuri, Aliza T. Brown, Sandra S. McCullough, Pippa Simpson, Laura P. James, Leah Hennings, Shun-Hwa Li
Publikováno v:
Toxicology and Applied Pharmacology. 264:192-201
Oxidative stress and mitochondrial permeability transition (MPT) are important mechanisms in acetaminophen (APAP) toxicity. The MPT inhibitor trifluoperazine (TFP) reduced MPT, oxidative stress, and toxicity in freshly isolated hepatocytes treated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccff854a2dbab8bb9402c6be7d07d7bb
https://doi.org/10.1016/j.taap.2012.08.001
https://doi.org/10.1016/j.taap.2012.08.001
Autor:
Laura W. Lamps, Sandra S. McCullough, Richard C. Kurten, Alessandra Milesi-Hallé, Jack A. Hinson, Laura P. James, Aliza T. Brown
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 110:327-334
Up-regulation of vascular endothelial growth factor (VEGF) is important to hepatocyte regeneration in the late stages of acetaminophen (APAP) toxicity in the mouse. This study was conducted to examine the relationship of hypoxia-inducible factor 1α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::053bbe067e5669a26a060b9f7b87eab6
https://doi.org/10.1111/j.1742-7843.2011.00812.x
https://doi.org/10.1111/j.1742-7843.2011.00812.x