Zobrazeno 1 - 10
of 607
pro vyhledávání: '"Jack A Tuszynski"'
Autor:
Chu Shiun Lo, Sara Ibrahim Omar, Jinlan Chang, Blessing Bassey-Archibong, Jack A Tuszynski, Nadia Jahroudi, Manijeh Pasdar
Publikováno v:
Re:GEN Open, Vol 3, Iss 1, Pp 40-51 (2023)
Background: The conformational p53-R175H is the most frequently occurring p53 mutant in cancers and a focus of mutant p53 targeted therapies. Plakoglobin is a dual cell adhesion and signaling protein with tumor suppressor activity. We previously show
Externí odkaz:
https://doaj.org/article/bd71a0ad83ac407888f30f165dbb77bf
Autor:
Sara Ibrahim Omar, Meng Zhao, Rohith Vedhthaanth Sekar, Sahar Arbabi Moghadam, Jack A Tuszynski, Michael T Woodside
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 1, p e1008603 (2021)
The coronavirus causing the COVID-19 pandemic, SARS-CoV-2, uses -1 programmed ribosomal frameshifting (-1 PRF) to control the relative expression of viral proteins. As modulating -1 PRF can inhibit viral replication, the RNA pseudoknot stimulating -1
Externí odkaz:
https://doaj.org/article/6c334b817bc846da905ffdeb82ddcbaf
Autor:
Elizabeth J Brant, Edward A Rietman, Giannoula Lakka Klement, Marco Cavaglia, Jack A Tuszynski
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0226883 (2020)
We analyzed protein expression data for Lupus patients, which have been obtained from publicly available databases. A combination of systems biology and statistical thermodynamics approaches was used to extract topological properties of the associate
Externí odkaz:
https://doaj.org/article/0274190597874c13857de6bb4f6c1832
Autor:
Sara Ibrahim Omar, Marco Gaetano Lepre, Umberto Morbiducci, Marco Agostino Deriu, Jack A Tuszynski
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0200769 (2018)
TP53 is the most mutated gene in all cancers. The mutant protein also accumulates in cells. The high frequency of p53 mutations makes the protein a promising target for anti-cancer therapy. Only a few molecules have been found, using in vitro screeni
Externí odkaz:
https://doaj.org/article/2d79a99bab0945a18426a28d8efafddc
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0202141 (2018)
Tubulin heterodimers are the building blocks of microtubules and disruption of their dynamics is exploited in the treatment of cancer. Electric fields at certain frequencies and magnitudes are believed to do the same. Here, the tubulin dimer's respon
Externí odkaz:
https://doaj.org/article/197c95d171f448e5acb8b52b1880577c
Autor:
Marco A Deriu, Gianvito Grasso, Jack A Tuszynski, Diego Gallo, Umberto Morbiducci, Andrea Danani
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004699 (2016)
The Josephin Domain (JD), i.e. the N-terminal domain of Ataxin 3 (At3) protein, is an interesting example of competition between physiological function and aggregation risk. In fact, the fibrillogenesis of Ataxin 3, responsible for the spinocerebbell
Externí odkaz:
https://doaj.org/article/e6b79b5611be47869d90618d3988fea7
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 6, p e1004313 (2015)
Microtubules are long filamentous hollow cylinders whose surfaces form lattice structures of αβ-tubulin heterodimers. They perform multiple physiological roles in eukaryotic cells and are targets for therapeutic interventions. In our study, we carr
Externí odkaz:
https://doaj.org/article/d7478414d1ba4da28ff54cb728ba4cc8
Autor:
Marc St George, Ahmed T Ayoub, Asok Banerjee, Cassandra D M Churchill, Philip Winter, Mariusz Klobukowski, Carol E Cass, Richard F Ludueña, Jack A Tuszynski, Sambasivarao Damaraju
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129168 (2015)
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-t
Externí odkaz:
https://doaj.org/article/f52f0efb56234a809812dbd19309eb40
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0115054 (2015)
In this report, we describe a strategy for the optimized selection of protein targets suitable for drug development against neoplastic diseases taking the particular case of breast cancer as an example. We combined human interactome and transcriptome
Externí odkaz:
https://doaj.org/article/5670dfc7ae6f40df9ecd362b312010de
Autor:
Marco A Deriu, Gianvito Grasso, Ginevra Licandro, Andrea Danani, Diego Gallo, Jack A Tuszynski, Umberto Morbiducci
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108677 (2014)
Spinocerebellar ataxia (SCA) 3, the most common form of SCA, is a neurodegenerative rare disease characterized by polyglutamine tract expansion and self-assembly of Ataxin3 (At3) misfolded proteins into highly organized fibrillar aggregates. The At3
Externí odkaz:
https://doaj.org/article/2f59ecd1952344208ffcfff335f0f730