Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Jack A Elias"'
Publikováno v:
eLife, Vol 11 (2022)
Coronavirus disease 2019 (COVID-19) is the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2; SC2), which has caused a worldwide pandemic with striking morbidity and mortality. Evaluation of SC2 strains demonstrated impres
Externí odkaz:
https://doaj.org/article/41c9c3983d4849f2a88d6ab0eea59c03
Autor:
Zhao Shan, Leike Li, Constance Lynn Atkins, Meng Wang, Yankai Wen, Jongmin Jeong, Nicolas F Moreno, Dechun Feng, Xun Gui, Ningyan Zhang, Chun Geun Lee, Jack A Elias, William M Lee, Bin Gao, Fong Wilson Lam, Zhiqiang An, Cynthia Ju
Publikováno v:
eLife, Vol 10 (2021)
Background: Hepatic platelet accumulation contributes to acetaminophen (APAP)-induced liver injury (AILI). However, little is known about the molecular pathways involved in platelet recruitment to the liver and whether targeting such pathways could a
Externí odkaz:
https://doaj.org/article/87bb9242be7e4ea1a0cab9c6806e6563
Autor:
Kelsey E Huntington, Anna D Louie, Chun Geun Lee, Jack A Elias, Eric A Ross, Wafik S El-Deiry
Publikováno v:
eLife, Vol 10 (2021)
Although the range of immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is variable, cytokine storm is observed in a subset of symptomatic individuals. To further understand the disease pathogenesis and, consequently, t
Externí odkaz:
https://doaj.org/article/227f3343cf834c569cb2cbdd08f31db4
Autor:
Suchitra Kamle, Bing Ma, Gail Schor, Madison Bailey, Brianna Pham, Inyoung Cho, Hina Khan, Christopher Azzoli, Mara Hofstetter, Takayuki Sadanaga, Roy Herbst, Katerina Politi, Chun Geun Lee, Jack A. Elias
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102108- (2024)
Non-small cell lung cancer (NSCLC) accounts for 85 % of all lung cancers. In NSCLC, 10–20 % of Caucasian patients and 30–50 % of Asian patients have tumors with activating mutations in the Epidermal Growth Factor Receptor (EGFR). A high percentag
Externí odkaz:
https://doaj.org/article/7cf65350cebe4083aaabd5218cb2e54f
Autor:
Darin L Wiesner, Charles A Specht, Chrono K Lee, Kyle D Smith, Liliane Mukaremera, S Thera Lee, Chun G Lee, Jack A Elias, Judith N Nielsen, David R Boulware, Paul R Bohjanen, Marc K Jenkins, Stuart M Levitz, Kirsten Nielsen
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004701 (2015)
Pulmonary mycoses are often associated with type-2 helper T (Th2) cell responses. However, mechanisms of Th2 cell accumulation are multifactorial and incompletely known. To investigate Th2 cell responses to pulmonary fungal infection, we developed a
Externí odkaz:
https://doaj.org/article/6f3bf1d6300e41919e7d294bbe3969cf
Autor:
Avignat S Patel, Jin Woo Song, Sarah G Chu, Kenji Mizumura, Juan C Osorio, Ying Shi, Souheil El-Chemaly, Chun Geun Lee, Ivan O Rosas, Jack A Elias, Augustine M K Choi, Danielle Morse
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121246 (2015)
Epithelial cell death is a major contributor to fibrogenesis in the lung. In this study, we sought to determine the function of mitochondria and their clearance (mitophagy) in alveolar epithelial cell death and fibrosis.We studied markers of mitochon
Externí odkaz:
https://doaj.org/article/73226e61a6ee4f418966c2cdc041e47f
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98629 (2014)
Obstructive sleep apnea (OSA) is a common disorder affecting 15-24% of the adults and is associated with increased risk of hypertension and atherosclerosis. The exact mechanisms underlying hypertension in OSA are not entirely clear. YKL-40/Chitinase-
Externí odkaz:
https://doaj.org/article/f753de86c55a444eb41c4836cd035311
Autor:
Soo Yeon Lee, Soo-Yeon Park, Seung-Hyun Lee, Hyunsik Kim, Jae-Hwan Kwon, Jung-Yoon Yoo, Kyunggon Kim, Moo Suk Park, Chun Geun Lee, Jack A. Elias, Myung Hyun Sohn, Hyo Sup Shim, Ho-Geun Yoon
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 8, Pp 1795-1805 (2023)
Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, fatal, fibrotic, interstitial lung disease of unknown cause. Despite extensive studies, the underlying mechanisms of IPF development remain unknown. Here, we found that p300 was upregulated i
Externí odkaz:
https://doaj.org/article/a8e2872f966d47e48824d6b5938f4e19
Autor:
Ashley Hernandez-Gutierrez, Sonoor Majid, Adam Eberle, Ashley Choi, Parand Sorkhdini, Dongqin Yang, Alina Xiaoyu Yang, Carmelissa Norbrun, Chuan Hua He, Chang-min Lee, Chun Geun Lee, Jack A. Elias, Yang Zhou
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 15 (2023)
Exaggerated Type 2 immune responses play critical roles in the pathogenesis of a variety of diseases including asthma, allergy, and pulmonary fibrosis. Recent studies have highlighted the importance of innate type 2 immune responses and innate lympho
Externí odkaz:
https://doaj.org/article/c6d844784f654362a9c8784710911f0e
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f6dda04f29c50d60686a529bb3a680
https://pubmed.ncbi.nlm.nih.gov/35679109
https://pubmed.ncbi.nlm.nih.gov/35679109