Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jack A Bibby"'
Autor:
Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Metabolic pathways are increasingly recognized as crucial determinants of T cell function. Here the authors show that the balance between IFNγ and IL-10 production in human CD4 T cells is modulated by the cholesterol biosynthetic pathway.
Externí odkaz:
https://doaj.org/article/419107e4daf14adaaf778f8b200485e9
Autor:
Fiona Clarke, Christine K Jordan, Enrique Gutiérrez-Martinez, Jack A Bibby, Cristina Sanchez-Blanco, Georgina H Cornish, Xuezhi Dai, David J Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P Cope, Harriet A Purvis
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186625 (2017)
The PTPN22R620W single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression
Externí odkaz:
https://doaj.org/article/fa86f2a42392422eaf03f48c18aab3f6
Autor:
Harriet A. Purvis, Fiona Clarke, Anna B. Montgomery, Chloe Colas, Jack A. Bibby, Georgina H. Cornish, Xuezhi Dai, Diana Dudziak, David J. Rawlings, Rose Zamoyska, Pierre Guermonprez, Andrew P. Cope
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Dendritic cells (DCs) are specialized antigen presenting cells that instruct T cell responses through sensing environmental and inflammatory danger signals. Maintaining the homeostasis of the multiple functionally distinct conventional dendritic cell
Externí odkaz:
https://doaj.org/article/dbd16a54534b4219875414603574c2bc
Autor:
Alexandra F. Freeman, Majid Kazemian, Jack A. Bibby, Daniel Chauss, Daniel S. Chertow, Michail S. Lionakis, Reuben McGregor, Tilo Freiwald, Nehal N. Mehta, Heather L. Teague, Luopin Wang, Audrey Kelly, Behdad Afzali, Estefania Nova-Lamperti, Kevin M. Vannella, Amna Malik, Daniella M. Schwartz, Bingyu Yan, Claudia Kemper, Didier Portilla, Giovanna Lombardi, Marcos J Ramos-Benitez, Susan D. John, Nichola Cooper, Arian Laurence, Paul Lavender, Erin E. West, Zonghao Zhang, Dhaneshwar Kumar
Publikováno v:
Nature immunology
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1 helper T (TH1) cell responses remain poorly understood. Here we show that complement triggers contraction of TH1 responses by inducing intrinsic expression of the vitam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b6f00ceb5d2ec52629d93280aeb2dd
http://europepmc.org/articles/PMC7612139
http://europepmc.org/articles/PMC7612139
Autor:
Jack A. Bibby, Divyansh Agarwal, Tilo Freiwald, Natalia Kunz, Nicolas S. Merle, Erin E. West, Andre Larochelle, Fariba Chinian, Somabha Mukherjee, Behdad Afzali, Claudia Kemper, Nancy R. Zhang
Publikováno v:
SSRN Electronic Journal.
SummaryNext generation sequencing technologies have revolutionized the study of T cell biology, capturing previously unrecognized diversity in cellular states and functions. Pathway analysis is a key analytical stage in the interpretation of such tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb56f836428b42b70be8cc7880e7a0a
https://doi.org/10.2139/ssrn.4024548
https://doi.org/10.2139/ssrn.4024548
Autor:
Jack A. Bibby, Divyansh Agarwal, Tilo Freiwald, Natalia Kunz, Nicolas S. Merle, Erin E. West, Parul Singh, Andre Larochelle, Fariba Chinian, Somabha Mukherjee, Behdad Afzali, Claudia Kemper, Nancy R. Zhang
Publikováno v:
Cell Reports. 41:111697
Pathway analysis is a key analytical stage in the interpretation of omics data, providing a powerful method for detecting alterations in cellular processes. We recently developed a sensitive and distribution-free statistical framework for multisample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f340dae75ef72e65b23d6a8b15313dc
https://doi.org/10.1016/j.celrep.2022.111697
https://doi.org/10.1016/j.celrep.2022.111697
Autor:
Richard Gregory, Luopin Wang, Nazish Malik, Nathalie Niyonzima, Charles J. Zhang, Jason R. Spence, Sonja Ghidelli-Disse, Matthew R. Olson, Marcus Bantscheff, Stefania Pittaluga, Tristan Frum, Majid Kazemian, Konstantinos D. Alysandratos, Jonathan Z. Sexton, Daniel Chauss, Darrell N. Kotton, Michail S. Lionakis, Carmen Mirabelli, Erin E. West, Didier Portilla, Bingyu Yan, Eva-Maria Nichols, Christiane E. Wobus, Tilo Freiwald, Shahram Kordasti, Martin Kolev, Behdad Afzali, Jack A. Bibby, Arian Laurence, Claudia Kemper
Publikováno v:
Science Immunology. 6
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical manifestations affecting the lungs, liver, kidneys and gut. Angiotensin converting enzyme (ACE) 2, the best-characterized entry receptor for the disease-causing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aa12e1c8d7eebe7b873f5801d4418b5
https://doi.org/10.1126/sciimmunol.abg0833
https://doi.org/10.1126/sciimmunol.abg0833
Autor:
Nicole Toepfner, Sarfaraz Hasni, Jack A. Bibby, Nicole Y. Morgan, Erin E. West, Andrew Conway Morris, Edwin R. Chilvers, Angel Aponte, Claudia Kemper, Natasha Jordan, Kathleen R. Bashant, Arlette Vassallo, Alexander J.T. Wood, Charlotte Summers, Jochen Guck, Martin P. Playford, Marjan Gucek, Nehal N. Mehta, Paniz Rezvan Sangsari, Davide Randazzo, Mariana J. Kaplan, Zerai Manna
Publikováno v:
Ann Rheum Dis
Funder: NHLI Foundation
Funder: NIHR Imperial Biomedical Research Centre; FundRef: http://dx.doi.org/10.13039/501100013342
Funder: National Heart Lung and Blood Institute
Funder: Medical Research Council; FundRef: http://dx.doi.org/10.
Funder: NIHR Imperial Biomedical Research Centre; FundRef: http://dx.doi.org/10.13039/501100013342
Funder: National Heart Lung and Blood Institute
Funder: Medical Research Council; FundRef: http://dx.doi.org/10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11ce8c9ef51ee1049ec36838ae9dada
https://www.repository.cam.ac.uk/handle/1810/310882
https://www.repository.cam.ac.uk/handle/1810/310882
Autor:
Heather L. Teague, Susan D. John, Alexandra F. Freeman, Michail S. Lionakis, Paul Lavender, Audrey Kelly, Claudia Kemper, Daniella M. Schwartz, Bingyu Yan, Amna Malik, Jack A. Bibby, Luopin Wang, Daniel Chauss, Nichola Cooper, Estefania Nova-Lamperti, Zonghao Zhang, Tilo Freiwald, Didier Portilla, Giovanna Lombardi, Erin E. West, Behdad Afzali, Arian Laurence, Nehal N. Mehta, Majid Kazemian, Reuben McGregor
Publikováno v:
bioRxiv
Pro-inflammatory immune responses are necessary for effective pathogen clearance, but cause severe tissue damage if not shut down in a timely manner1,2. Excessive complement and IFN-γ-associated responses are known drivers of immunopathogenesis3 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014af295866fa83a0164e211b25c7d2d
https://pubmed.ncbi.nlm.nih.gov/32743590
https://pubmed.ncbi.nlm.nih.gov/32743590
Autor:
Arian Laurence, Shahram Kordasti, Matthew R. Olson, Didier Portilla, Daniel Chauss, Luopin Wang, Claudia Kemper, Majid Kazemian, Michail S. Lionakis, Jack A. Bibby, Bingyu Yan, Erin E. West, Behdad Afzali, Tilo Freiwald
Publikováno v:
Research Square
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Patients with coronavirus disease 2019 (COVID-19) present with a range of devastating acute clinical manifestations affecting the lungs, liver, kidneys and gut. The best-characterized entry receptor for the disease-causing virus SARS-CoV2, angiotensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f43b68cad15da519435e3da9db04f6
http://europepmc.org/articles/PMC7336704
http://europepmc.org/articles/PMC7336704